Update 2000

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  Elizabeth Salas &
  Melissa Valadez
  Humans and Viruses
  Human Biology 115A
  Winter, 2000
  Robert Siegel,

  Date completed: 3/6/00

Human Adenovirus 5 (h-Ad5)
The Adeno5:
The Musical Group of Colds, Brought to you by Unwashed Hands

Description of virus (taxonomy): Family - Adenoviridae, Genus - Mastadenovirus Icosahedral, dsDNA, monopartitie, non-enveloped, 70-90 nm, Encodes around 30 proteins, 47 serotypes exists assigned to 6 subgenera (A-F), Serotype 5 belongs to the Subgenus C

Power (virulence)
Depending on the immunity of the recipient, h-Ad5 can produce from asymptomatic to mild symptoms up to dangerous symptoms. Offenses
      Attacks (Mode of replication, transmission)
      Transmitted by ingestion or by respiration
      Affinity for cells of the intestinal tract, conjuctival
            and respiratory epithelium
      Enter the cell through endocytosis
      Outer capsid is removed, and core enters the nucleus
      Replication and assembly in the nucleus
      Particles released through cell destruction
      Outcome (Syndrome, Symptoms)
      Infection is often asymptomatic, can also cause
            persistent infections
      Persists asymptomatically for years in the tonsils and
            adenoids of a child
      Virus is shed continuously in the feces for many months after
            the initial infection, then intermittently for years thereafter
      Common serotypes of subgenus C characterized by prolonged
            latency in lymphoid tissues, in immunocompromised
            individuals, recovered in blood
      Pharyngitis: Results in cough, nasal congestion, fever,
            inflamed throat.
      Usually occurs in young children
      Pneumonia: Can be severe and fatal in children. (Most common
            among 3 and 7, but can be associated with 5)
      Generalized: In AIDS patients causes generalized syndromes
      Adenoviruses can cause life-threatening complications in children
            with immune deficiency disease, organ transplant patients,
            and AIDS patients.
      Speed (Incubation Period, Replication Speed)
            Displays seasonal variation
            Short incubation period (5-8) days
      Vaccines exists for certain strains, primarily used in military
      Behavioral (Prevention)
      Personal hygiene, including hand washing, can be
      adequate measure in prevention.
      Over the counter painkillers and symptomatic relief
Game action
Your child from daycare brings home an infection of Human Adenovirus 5 (h-Ad5). As a result, the child must stay home until she is better and can return to daycare. Lose a week's wages.