St. Louis Encephalitis
Elizabeth Salas &
Humans and Viruses
Human Biology 115A
Date completed: 3/6/00
Icosahedral, (+) ssRNA, monopartite, enveloped, 40-50nm,
Most devastating encephalitis disease in the United States
Attacks (Mode of replication, transmission)
Natural reservoir in birds. Transmission through Culex mosquitoes that feed mainly on birds
Transmitted primarily arthropod borne (mosquito bites)
Enter cell through receptor-mediated endocytosis, ph dependent fusion Replication takes place in cytoplasma
Fully formed viruses appear within endoplasmic reticulum and released through cell lysis
Outcome (Syndrome, Symptoms)
Symptoms are usually mild and include fever, headache, tiredness, and dizziness In the most severe cases, encephalitis results leading to death
Speed (Incubation Period, Replication Speed)
Long latent period, 12 hours or more
Currently there are no prospects of vaccine
Flaviviruses are generally not stable in the environment and can be inactivated by heat,
and by disinfectants containing detergents or lipid solvents.
Found primarily in Americas, greater awareness of disease in Americas
Since transmitted through mosquitoes, protective clothing can stop transmission. When outside, wear long pants and long-sleeved shirts. Individual living in environment conducive for mosquitoes can lead to increased transmission. Stay indoors between dusk and dark. This is when the mosquitoes are most active in their search for food.
Mosquitoes breed in stagnant, polluted waters prevent the development of mosquito breeding grounds Spray exposed skin with insect repellent.
There is no specific treatment for St. Louis encephalitis       Care of patients centers on treatment of symptoms and complications       Prevention is the key
Neighbor to the right falls ill with St. Louis Encephalitis and loses a turn. You must now inform all players of how virus is transmitted and preventative methods against St. Louis Encephalitis.