DRUG PROFILE (Directly Quoted from Source)

Bovine Colostrum

TRADE NAMES

Mega Bovine Colostrum (Bricker Labs)

DESCRIPTION

Colostrum is derived from the pre-milk fluid produced from a cow's mammary glands with in the first few days after birth. Bovine colostrum is a source of antibodies, growth factors and nutrients which generates immunity against viruses that affect the gastrointestinal tract.

The protein content of bovine colostrum has three to four times higher value that the protein level found in cow's milk. These include immunoglobulins and growth factors such as IGF-1, IGF-2, TGFbeta and EGF. Hyperimmune bovine colostrum contains a high level of IgG type, which is protective against rotaviruses.

ACTIONS AND PHARMACOLOGY

Bovine colostrum can be used to stimulate immunity and works efficiently as an antiviral. There is also an ergogenic activity reported with bovine colostrum use.

MECHANISM OF ACTION

Hyperimmune bovine colostrum has antiviral activity based on the ability of specific immunoglobulins of the IgG type to react with virses in the gut. Bovine colostrum contains a few immunostimulatory substances, including lactoferrin and colostrinin or proline-rich polypeptide (PRP) which is an iimmunomodulatory substance. The combination of specific, as well as nonspecific, IgGs and such immunomodulatory factors as lactoferrin and PRP may afford general antimicrobial protection of the gastrointestinal tract.

PHARMACOKINETICS

It would be expected that immunoglobulins found in bovine colostrum would be rapidly inactivated by stomach acid and proteolytic action in the small intestine. Enteric coating would protect the proteins from acid in the stomach but not from proteolytic activity in the small intestine. However, following ingestion of bovine colostrum, some immunoglobulins are found to be excreted intact in the feces after a few days. This suggests that some immunoglobulins may be more resistant to degradation in the gut.

Growth factors and other peptides and proteins in bovine colostrum are most likely degraded by proteolytic enzymes and absorbed, distributed and metabolized in the same fashion as similar dietary substances.

INDICATIONS AND USAGE

Claims made for bovine colostrum are mostly unsubstantiated. Some preparations may have some antimicrobial effects. There is no credible evidence to support claims that bovine colostrum burns fat, builds muscle, speeds healing of injuries, regulates blood sugars, improves mood and fights depression or that it has anti-cancer effects.

PRECAUTIONS

Use of Bovine colostrum should be retricted among pregnant women and nursing mothers.

Bovine colostrum contains insulin-like growth factor-1 (IGF-1). IGF-1 levels are elevated in prostate, colorectal and lung cancer. Recent studies have found that IGF-1 levels correlate with risk of prostate cancer and colorectal cancer in men, premenopausal breast cancer in women and lung cancer in both men and women. Those with these types of cancer and those at risk for these cancers should exercise caution in the use of bovine colostrum supplements. It is unlikely that the amount of IGF-1 in bovine colostrum would be a problem, but caution should still be exercised.

ADVERSE REACTIONS

Adverse reactions to bovine colostrum supplements are mainly gastrointestinal and include nausea and vomiting, bloating and diarrhea. Bovine colostrum is generally well tolerated.

DOSAGE AND ADMINISTRATION

Bovine colostrum is available in several forms, including tablets, powders, bars and liquid solutions. Dosage is variable. Hyperimmune bovine colostrum used for AIDS-associated diarrhea usually caused by Cryptosporidium parvum is dosed at 10 grams four times daily for 21 days. This must only be taken under medical supervision.

HOW SUPPLIED

Powder

Tablets 1000 mg

* Direct Source:

PDR Health http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/bov_0082.shtml

 

 

 


 

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