infectious proteins, diseases of abnormal polymerization
progressive spongiform encephalopathy
diffuse neuronal degenerations, especially in cerebral cortex and basal ganglia
motor disfunction: ataxia, hyperreflexivity, spasticity
death, usually from starvation (not able to coordinate swallowing)
kuru can remain latent for 4-20 years, usually remains latent in women until after menopause.
Pathogenesis is thought to depend on a relatively low probability event so progression is slow
Among the Fore, once pathogenesis is initiated, progression to death occurs quickly, typically within a year or two
elimination of cannibalism among the Fore people of the Eastern Highlands of New Guinea has eliminated kuru. The disease was transmitted through the ingestion of or handing of infected human brain tissue.
Some theorize that cooling may have a protective effect against infection, but prions are characteristically highly stable and resistant to breakdown
GAME ACTION: you cannot move from your spot, but you can latch on to the next person who comes through this space and attack in 5 turns