Principal Investigator(s): Shan X. Wang & James D. Brooks

Sponsor: NCI Early Detection Research Network - EDRN

We are adapting the magnetic nanosensor array platform to the multiplex measurement of prostate cancer biomarkers for detection and progression. We can simultaneously interrogate a single 30 ul serum sample for our entire panel of biomarkers, and the enhanced sensitivity will enable the measurement of low levels of biomarkers produced by small early primary tumors and microscopic occult metastatic foci. Our goals for detection are to improve upon sensitivity (for detecting cancers in men with PSA < 4 ng/ml) and specificity (to identify men with PSA > 4 ng/ml who do not have cancer).