Selected Publications

Whitlock JP Jr
Induction of cytochrome P4501A1
Annu Rev Pharmacol Toxicol 1999; 39: 103-25.

Okino ST, Chichester CH, Whitlock JP Jr
Hypoxia-inducible mammalian gene expression analyzed in vivo at a TATA-driven promoter and at an initiator-driven promoter.
J Biol Chem 1998 Sep 11; 273(37): 23837-43.

Gao L, Dong L, Whitlock JP Jr
A novel response to dioxin. Induction of ecto-ATPase gene expression.
J Biol Chem 1998 Jun 19; 273(25): 15358-65.

Dong L, Ma Q, Whitlock JP Jr
Down-regulation of major histocompatibility complex Q1b gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J Biol Chem. 1997 Nov 21; 272(47): 29614-29619. PDF fulltext reprint

Ko HP, Okino ST, Ma Q, Whitlock JP Jr
Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.
Mol Cell Biol. 1997 Jul; 17(7): 3497-3507.

Ma Q, Whitlock JP Jr
A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J Biol Chem. 1997 Apr 4; 272(14): 8878-8884. PDF fulltext reprint

Li H, Ko HP, Whitlock JP
Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1alpha.
J Biol Chem. 1996 Aug 30; 271(35): 21262-21267. PDF fulltext reprint

Whitlock JP Jr, Okino ST, Dong L, Ko HP, Clarke-Katzenberg R, Ma Q, Li H
Cytochromes P450 5: induction of cytochrome P4501A1: a model for analyzing mammalian gene transcription.
FASEB J. 1996 Jun; 10(8): 809-818. Review.

Ma Q, Whitlock JP Jr
The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin.
Mol Cell Biol. 1996 May; 16(5): 2144-2150.

Dong L, Ma Q, Whitlock JP Jr
DNA binding by the heterodimeric Ah receptor. Relationship to dioxin-induced CYP1A1 transcription in vivo.
J Biol Chem. 1996 Apr 5; 271(14): 7942-7948. PDF fulltext reprint

Ko HP, Okino ST, Ma Q, Whitlock JP Jr
Dioxin-induced CYP1A1 transcription in vivo: the aromatic hydrocarbon receptor mediates transactivation, enhancer-promoter communication, and changes in chromatin structure.
Mol Cell Biol. 1996 Jan; 16(1): 430-436.

Okino ST, Whitlock JP Jr
Dioxin induces localized, graded changes in chromatin structure: implications for Cyp1A1 gene transcription.
Mol Cell Biol. 1995 Jul; 15(7): 3714-3721.

Ma Q, Dong L, Whitlock JP Jr
Transcriptional activation by the mouse Ah receptor. Interplay between multiple stimulatory and inhibitory functions.
J Biol Chem. 1995 May 26; 270(21): 12697-12703. fulltext

Li H, Dong L, Whitlock JP Jr
Transcriptional activation function of the mouse Ah receptor nuclear translocator.
J Biol Chem. 1994 Nov 11; 269(45): 28098-28105.

Elferink CJ, Whitlock JP Jr
Dioxin-dependent, DNA sequence-specific binding of a multiprotein complex containing the Ah receptor.
Receptor. 1994; 4(3): 157-173.

Whitlock JP Jr
Mechanistic aspects of dioxin action.
Chem Res Toxicol. 1993 Nov; 6(6): 754-763. Review. No abstract available.

Lusska A, Shen E, Whitlock JP Jr
Protein-DNA interactions at a dioxin-responsive enhancer. Analysis of six bona fide DNA-binding sites for the liganded Ah receptor.
J Biol Chem. 1993 Mar 25; 268(9): 6575-6580.

Wu L, Whitlock JP Jr
Mechanism of dioxin action: receptor-enhancer interactions in intact cells.
Nucleic Acids Res. 1993 Jan 11; 21(1): 119-125.

Morgan JE, Whitlock JP Jr
Transcription-dependent and transcription-independent nucleosome disruption induced by dioxin.
Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23): 11622-11626.

Lusska A, Wu L, Whitlock JP Jr
Superinduction of CYP1A1 transcription by cycloheximide. Role of the DNA binding site for the liganded Ah receptor.
J Biol Chem. 1992 Jul 25; 267(21): 15146-15151.

Wu L, Whitlock JP Jr
Mechanism of dioxin action: Ah receptor-mediated increase in promoter accessibility in vivo.
Proc Natl Acad Sci U S A. 1992 Jun 1; 89(11): 4811-4815.

Shen ES, Whitlock JP Jr
Protein-DNA interactions at a dioxin-responsive enhancer. Mutational analysis of the DNA-binding site for the liganded Ah receptor.
J Biol Chem. 1992 Apr 5; 267(10): 6815-6819.

Elferink CJ, Gasiewicz TA, Whitlock JP Jr
Protein-DNA interactions at a dioxin-responsive enhancer. Evidence that the transformed Ah receptor is heteromeric.
J Biol Chem. 1990 Nov 25; 265(33): 20708-20712.

Wen LP, Koeiman N, Whitlock JP Jr
Dioxin-inducible, Ah receptor-dependent transcription in vitro.
Proc Natl Acad Sci U S A. 1990 Nov; 87(21): 8545-8549.

Jones KW, Whitlock JP Jr
Functional analysis of the transcriptional promoter for the CYP1A1 gene.
Mol Cell Biol. 1990 Oct; 10(10): 5098-5105.

Fisher JM, Wu L, Denison MS, Whitlock JP Jr
Organization and function of a dioxin-responsive enhancer.
J Biol Chem. 1990 Jun 15; 265(17): 9676-9681.

Elferink CJ, Whitlock JP Jr
2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA.
J Biol Chem. 1990 Apr 5; 265(10): 5718-5721.

Durrin LK, Whitlock JP Jr
2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription.
Mol Cell Biol. 1989 Dec; 9(12): 5733-5737.

Shen ES, Whitlock JP Jr
The potential role of DNA methylation in the response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J Biol Chem. 1989 Oct 25; 264(30): 17754-17758.

Denison MS, Fisher JM, Whitlock JP Jr
Protein-DNA interactions at recognition sites for the dioxin-Ah receptor complex.
J Biol Chem. 1989 Oct 5; 264(28): 16478-16482.

Denison MS, Fisher JM, Whitlock JP Jr
The DNA recognition site for the dioxin-Ah receptor complex. Nucleotide sequence and functional analysis.
J Biol Chem. 1988 Nov 25; 263(33): 17221-17224.

Denison MS, Fisher JM, Whitlock JP Jr
Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.
Proc Natl Acad Sci U S A. 1988 Apr; 85(8): 2528-2532.

Durrin LK, Whitlock JP Jr
In situ protein-DNA interactions at a dioxin-responsive enhancer associated with the cytochrome P1-450 gene.
Mol Cell Biol. 1987 Aug; 7(8): 3008-3011.

Jones PB, Durrin LK, Fisher JM, Whitlock JP Jr
Control of gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin. Multiple dioxin-responsive domains 5'-ward of the cytochrome P1-450 gene.
J Biol Chem. 1986 May 25; 261(15): 6647-6650.

Jones PB, Durrin LK, Galeazzi DR, Whitlock JP Jr
Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.
Proc Natl Acad Sci U S A. 1986 May; 83(9): 2802-2806.

Israel DI, Estolano MG, Galeazzi DR, Whitlock JP Jr
Superinduction of cytochrome P1-450 gene transcription by inhibition of protein synthesis in wild type and variant mouse hepatoma cells.
J Biol Chem. 1985 May 10; 260(9): 5648-5653.

Jones PB, Galeazzi DR, Fisher JM, Whitlock JP Jr
Control of cytochrome P1-450 gene expression by dioxin.
Science. 1985 Mar 22; 227(4693): 1499-1502.

Jones PB, Miller AG, Israel DI, Galeazzi DR, Whitlock JP Jr
Biochemical and genetic analysis of variant mouse hepatoma cells which overtranscribe the cytochrome P1-450 gene in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin.
J Biol Chem. 1984 Oct 25; 259(20): 12357-12363.

Israel DI, Whitlock JP Jr
Regulation of cytochrome P1-450 gene transcription by 2,3,7, 8-tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells.
J Biol Chem. 1984 May 10; 259(9): 5400-5402.

Whitlock JP Jr, Galeazzi DR
2,3,7,8-Tetrachlorodibenzo-p-dioxin receptors in wild type and variant mouse hepatoma cells. Nuclear location and strength of nuclear binding.
J Biol Chem. 1984 Jan 25; 259(2): 980-985.

Israel DI, Whitlock JP Jr
Induction of mRNA specific for cytochrome P1-450 in wild type and variant mouse hepatoma cells.
J Biol Chem. 1983 Sep 10; 258(17): 10390-10394.

Miller AG, Israel D, Whitlock JP Jr
Biochemical and genetic analysis of variant mouse hepatoma cells defective in the induction of benzo(a)pyrene-metabolizing enzyme activity.
J Biol Chem. 1983 Mar 25; 258(6): 3523-3527.

Miller AG, Whitlock JP Jr
Novel variants in benzo(a)pyrene metabolism. Isolation by fluorescence-activated cell sorting.
J Biol Chem 1981 Mar 10; 256(5): 2433-7


Dept. of Molecular Pharmacology

Stanford University Medical Center

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Originally created by Felix W. Frueh
Updated and maintained by Caroline Johnston
Updated 7/99