FGAP - Description
This program developed by J Halpern and AS Whittemore can be used to detect association between a disease and a diallelic polymorphism
of a candidate gene by analyzing genotypes in arbitrary types of nuclear families.
FGAP is written in Java and hence must be run from a computer on which there
is a Java runtime environment. The program can be run using a Graphical
User's Interface, from the command line, or in "batch."
See the associated "README" file
for full details.
FGap - ReferencesA detailed description of the statistical underpinnings of the software can be found in the following articles:
Shih M-C, Whittemore AS. Tests for genetic association using family data. Genet Epidemiol 22: 128-145, 2002.
Whittemore AS, Tu I-P. Detecting disease genes using family data. I. Likelihood-based theory. Am J Hum Genet 66: 1328-1340, 2000. Full Text
Tu I-P, Balise RR, Whittemore AS. Detecting disease genes using family data. II. Application to nuclear families. Am J Hum Genet 66: 1341-1350, 2000. Full Text
Clayton D. A generalization of the transmission/disequilibrium test for uncertain-haplotype transmission. Am J Hum Genet 65: 1170-1177, 1999. Full Text
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This document was last modified:
Thursday, 16-Nov-2006 16:28:02 PST