Selected publications from Matin Laboratory


See end of this section for patents & submitted manuscripts

Haiyu Zhang, Adam L Cohen, Sujatha Krishnakumar, Irene L Wapnir, Selvaraju Veeriah, Glenn Deng, Marc A Coram, Caroline M Piskun, Teri A Longacre, Michael Herrler, Daniel O Frimannsson, Melinda L Telli, Frederick M Dirbas, AC Matin, Shanaz H Dairkee, Banafshe Larijani, Gennadi V Glinsky, Andrea H Bild and Stefanie S Jeffrey. 2014. Patient-derived xenografts of triple-negative breast cancer reproduce molecular features of patient tumors and respond to mTOR inhibition. Breast Cancer Research 2014, 16:R36 ( [PDF].

Eswaramoorthy S, Poulain S, Hienerwadel R, Nicolas B, Sylvester M, Zhang Y, Berthoeau C, Van D-L, and Matin A. 2012. Crystal Structure of ChrR – A Quinone Reductase with the Capacity to Reduce Chromate. PLoS One, April 2012 | Volume 7 | Issue 4 | e36017 [PDF]. Full article with supplementary material is available at:

Benoit, MR, Conant, C, Ionescu-Zanetti, C, Schwartz, M, and Matin, A. New device for high throughput viability screening of flow-bioflims. 2010.  Applied and Environmental Microbiology 76 (13): 4136-4142 [PDF]

Barak, Y., F. Schreiber, S.H. Thorne, C.H. Contag, D. deBeer, and Matin, A . 2010. Role of nitric oxide in Salmonella typhimurium-mediated cancer cell killing. BMC Cancer 10: 146-152 [PDF]

Michael R Benoit, Dirk Mayer, Yoram Barak, Ian Y Chen, Wei Hu,  Zhen Cheng, Shan X Wang, Daniel M Spielman, Sanjiv S Gambhir, A Matin. 2009. Visualizing implanted tumors in mice with MRI using magnetotactic bacteria.Clinical Cancer Research 15 (16): 5170 - 5177, Manuscript [PDF] Suppl mat. [PDF]

Steve H. Thorne, Yoram Barak, Wenchuan Liang, Michael H. Bachmann, Jianghong Rao, Christopher H. Contag and A. Matin. 2009. CNOB/ChrR6, a new prodrug enzyme cancer chemotherapy.- Molecular Cancer Therapeutics 8(2): 333-341, Ms [PDF]; Suppl. figures [PDF]; Suppl. tables [PDF]; Video [PDF]

A Matin. Stress, Bacterial: General and Specific. Encyclopedia of Microbiology.  (Moselio Schaechter, Editor), pp. 485-500 Oxford: Elsevier. Publisher does not permit posting of the article.

Barak, Y., Y. Nov., D. Ackerley, and A. Matin. 2008. Enzyme improvement in the absence of structural knowledge - a novel approach. ISME Journal, 2: 171-179 [PDF]. Suppl mat. [PDF]

S.V. Lynch, L. Dixon, M.R. Benoit, E.L. Brodie, M. Keyhan, P. Hu, D.F. Ackerley, G.L. Andersen and A. Matin. 2007. Role of the rapA Gene in Controlling Antibiotic Resistance of Escherichia coli Biofilms. Antimicrobial Agents and Chemotherapy, 51 (10): 3650-3658 [PDF]

Matin, A., and S. Lynch, and M. R. Benoit. 2006. Increased bacterial resistance and virulence in simulated microgravity and its molecular basis. Gravitation and Space Biology 19(2): 31-42 [PDF]

Lynch, S.V., K. Mukundakrishnan, M. R. Benoit, P. Ayyaswami, and A. Matin. 2006. Escherichia coli biofilms formed under low shear simulated microgravity in a ground-based system. Applied & Environmental Microbiology 72 (12): 7701-7710 [PDF]

Barak, Y., D. F. Ackerley, C. J. Dodge, B. Lal, A. Cheng, A. J. Francis, and A. Matin. 2006. Analysis of novel soluble Cr(VI) and U(VI) reductases and generation of improved enzymes using directed evolution. Applied and Environmental Microbiology  72 (11): 7074-7082 [PDF]

Ackerley, D.F., Y. Barak, S.V. Lynch, J. Curtin, and A. Matin. 2006. Effect of chromate stress on Escherichia coli K12. Journal of Bacteriology 188 (9): 3371-3381. [PDF]

Barak, Y , Stephen H. Thorne, David F. Ackerley, Susan V. Lynch, Christopher H. Contag, and A. Matin. 2006. New enzyme for reductive cancer chemotherapy (YieF) and its improvement by directed evolution. Molecular Cancer Therapeutics 5(1): 97-103. [PDF]

Matin A., and S. V. Lynch. 2005. Investigating the Threat of Bacteria Grown in Space. ASM News 71(5): 235-240 [PDF]

Lynch S. V. and A. Matin. 2005. Travails of microgravity:man and microbes in space. Biologist 52(2): 80-87 [PDF]

Gonzalez C.F., D.F. Ackerley, S.V. Lynch, and A. Matin. 2005. ChrR, A soluble quinone reductase of Pseudomonas Putida that defends against H2O2. The Journal of Biological Chemistry. 280(24): 22590-22595. [PDF]

Ackerley, D.F., C.F. Gonzalez, C.H. Park, R. Blake II, M. Keyhan, and A. Matin. 2004. Mechanism of chromate reduction by the Escherichia coli protein, NfsA, and the role of different chromate reductases in minimizing oxidative stress during chromate reduction. Environmental Microbiology 6 (8): 851-860 [PDF]

Ackerley, D.F., C.F. Gonzalez, C.H. Park, R. Blake II, M. Keyhan, and A. Matin. 2004. Chromate reducing properties of soluble flavoproteins from Pseudomonas putida and Escherichia coli. Applied & Environmental Microbiology 70: 873-882 [PDF]

Keyhan, M. , D. F. Ackerley, and A. Matin. 2004. Targets of improvement in bacterial chromate bioremediation. In: M. Pellei and A. Porta (Eds.), Remediation of Contaminated Sediments -- 2003. Proceedings of the Second International Conference on Remediation of Contaminated Sediments (Venice, Italy; 30 Sep-3 Oct 2003). ISBN 1-57477-143-4, published by Battelle Press, Columbus, OH. [PDF]

Lynch, S., E.L. Bradie, and A. Matin. 2004. Role and regulation of sigmaS in low shear simulated microgravity-conferred general resistance in Escherichia coli. Journal of Bacteriology 186 (24): 8207-8212 [PDF]

Gonzalez, C.F., D. F. Ackerley, C. H. Park, M. Keyhan, and A. Matin. 2003. A soluble flavoprotein contributes to chromate reduction and tolerance by Pseudomonas putida. Acta Biotechnol. 23: 233-239 [PDF]

Stone, G., P. Wood, L. Dixon, M. Keyhan and A. Matin. 2002. Tetracycline rapidly reaches all the constituent cells of uropathogenic Escherichia coli biofilms. Antimicrobial Agents and Chemotherapy 46: 2458-2461. [PDF]

Park, C-H., M. Keyhan, B. Wielinga, S. Fendorf, and A. Matin. 2000. Purification to homogeneity and charcterization of a novel Pseudomonas putida chromate reductase. Applied & Environmental Microbiology 66 (5): 1788-1795. [PDF]

Xiong, A., A. Gottman, C. Park, M. Baetens, S. Pandza, and A. Matin. 2000. The EmrR protein represses the Escherichia coli emrRAB multidrug resistance operon by directly binding to its promoter region. In press, Antimicrobial Agents and Chemotherapy. [PDF]

Pandza. S., M. Baetens, C-H. Park, T. Au, M. Keyhan, and A. Matin. 2000. The putative G-protein FLHF has a role in polar flagellar placement and general stress response induction in Pseudomonas putida. Molecular Microbiology 36: 414-423 [PDF]

Matin, A., M. Baetens, S. Pandza, C.H. Park, and S. Waggoner. 1999. Survival strategies in the stationary phase. In Microbial Ecology of Infectious Disease (E. Rosenberg, editor), American Society for Microbiology: Washington D.C., pp. 30-48

Saier, M. H., I.T. Paulsen, and A. Matin. 1997. A Bacterial Model System for Understanding Multidrug Resistance. Microbial Drug Resistance, 3:289-295. [PDF]

Matin, A., C.D. Little, C.D. Fraley, and M. Keyhan. 1995. Use of starvation promoters to limit growth and selectively express trichloroethylene and phenol transformation activity in recombinant Escherichia coli. Applied and Environmental Microbiology, 61:3323-3328. [PDF]


Reducing chromium and/or uranium involves contacting them with a Escherichia coli nitroreductase polypeptide having amino acid alteration relative to wild-type enzyme, and produces enhanced enzyme kinetics for reduction of toxic metals
Patent Number(s): US2007254355-A1

Cultivating magnetotactic bacterium, useful e.g. for enhancing contrast of magnetic resonance image, comprises obtaining isolated strain of magnetotactic bacteria, and cultivating the bacteria in growth medium comprising iron salt

Patent Number(s): US2010135912-A1

Nitroreductase enzymes
Patent Number(s): US 07687474