Chromatin regulators play essential roles in development and disease. We are interested in understanding the molecular mechanisms of chromatin remodeling that contribute to human health. To do this, we are developing new techniques for single-cell sequencing and single-molecule imaging, opening new avenues to study their function.
Biological systems are complex and heterogeneous. Averaging over thousands or millions of cells obscures the true function of chromatin regulators. By examining cells individually, we see patterns emerge even in mixed populations, revealing molecular function in concrete quantitative terms.
The epigenetic landscape represents the sum physico-chemical state of the genetic material. This dynamic system permits diverse cell types to arise from a single genome. We are integrating next-generation sequencing and live-cell microscopy to reveal the biophysical mechanisms that lie at the heart of epigenetics and disease.
We are integrating next-generation sequencing and live-cell microscopy to reveal the biophysical mechanisms at the heart of epigenetics and disease.
NextGen Star of the American Association for Cancer Research, 2015
Postdoctoral fellow of the American Cancer Society, 2012