We study the molecular mechanisms of chromatin regulation that contribute to human health. To do this, we are developing new single-cell and single-molecule assays, opening new avenues to explore biological function.
Biological systems are complex and heterogeneous. Averaging over large numbers of cells obscures the true function of chromatin regulators. By examining cells individually, we see patterns emerge even in mixed populations.
The epigenetic landscape is the bridge that connects the genome with its environment. We are integrating next-generation sequencing and live-cell microscopy to reveal the biophysical mechanisms that lie at the heart of epigenetics.
We are integrating next-generation sequencing and live-cell microscopy to reveal the biophysical mechanisms at the heart of epigenetics and disease.
NextGen Star of the American Association for Cancer Research, 2015
Postdoctoral fellow of the American Cancer Society, 2012