Research / Single-cell epigenomics

The origins of phenotypic diversity

In many cancers and developmental disorders, alterations of epigenetic regulators are common. These changes alter the balance of regulatory factors in the cell, generating phenotypic diversity during expansion and selection of tumor cells. Phenotypic diversity (reflected by global patterns of RNA transcription) underlies critical aspects of tumor biology, such as metastasis and drug resistance. Unfortunately, there are currently no frameworks to characterize epigenetic and phenotypic diversity. Addressing this will require quantitative techniques to characterize the distributions of global mRNA levels.

We are using single-cell RNA-seq to study the contributions of chromatin regulators towards generating phenotypic diversity in cancer and development. Planning for the lab is happening now. If you are interested in the research we are doing, please contact Courtney for more information.

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