I am very excited to announce that I have accepted a position as an assistant professor in the Department of Molecular Genetics and Microbiology (MGM)within the Duke University School of Medicine. I will be starting in June (2018) and am looking forward to expanding our knowledge of vertebrate evolution and human disease. We will mix computational and experimental techniques to address what genetic mutations predispose us to disease and underlie key adaptive traits.
I am currently a postdoc in David Kingsley's lab at Stanford University. I am interested in understanding the genetic mutations that have resulted in phenotypic differences between species as well as differences between individuals of the same species.
I did my PhD work in David Haussler's lab at the University of California, Santa Cruz.
My undergraduate degree is in computer science from Cornell University's College of Engineering.
My work on vertebate genetics has been covered by some popular news sources. I was interviewed by Joe Palca on NPR during All Things Considered to talk about gene regulatory changes. My work on the genetics of dinosaurs was covered in the National Audubon Scociety's magazine as well as National Geographic's blog by Carl Zimmer.
Lowe CB*, Sanchez-Luege N*, Howes TR, Brady SD, Richardson RR, Jones FC, Bell MA, Kingsley DM.
Detecting Copy Number Variation Associated With Phenotypic Classes.
Genome Res. 2016. In revision.
Lowe CB, Clarke JA, Baker AJ, Haussler D, Edwards SV.
Feather development genes and associated regulatory innovation predate the origin of Dinosauria.
Mol Biol Evol. 2015 Jan;32(1):23-8.
Lowe CB, Haussler D.
29 mammalian genomes reveal novel exaptations of mobile elements for likely regulatory functions in the human genome.
PLoS One. 2012;7(8):e43128.
29 mammals sequencing and analysis consortium.
A high-resolution map of human evolutionary constraint using 29 mammals.
Nature. 2011 Oct 12;478(7370):476-82.
Anolis genome sequencing consortium.
The genome of the green anole lizard and a comparative analysis with birds and mammals.
Nature. 2011 Aug 31;477(7366):587-91.
Lowe CB, Kellis M, Siepel A, Raney BJ, Clamp M, Salama SR, Kingsley DM, Lindblad-Toh K, Haussler D.
Three periods of regulatory innovation during vertebrate evolution.
Science. 2011 Aug 19;333(6045):1019-24.
McLean CY, Bristor D, Hiller M, Clarke SL, Schaar BT, Lowe CB, Wenger AM, Bejerano G.
GREAT improves functional interpretation of cis-regulatory regions.
Nat Biotechnol. 2010 May;28(5):495-501.
Lowe CB, Bejerano G, Salama SR, Haussler D.
Endangered species hold clues to human evolution.
J Hered. 2010 Jul-Aug;101(4):437-47.
Zhu J, Sanborn JZ, Diekhans M, Lowe CB, Pringle TH, Haussler D.
Comparative genomics search for losses of long-established genes on the human lineage.
PLoS Comput Biol. 2007 Dec;3(12):e247.
Wang T, Zeng J, Lowe CB, Sellers RG, Salama SR, Yang M, Burgess SM, Brachmann RK, Haussler D.
Species-specific endogenous retroviruses shape the transcriptional network of the human tumor suppressor protein p53.
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18613-8.
Lowe CB, Bejerano G, Haussler D.
Thousands of human mobile element fragments undergo strong purifying selection near developmental genes.
Proc Natl Acad Sci U S A. 2007 May 8;104(19):8005-10.