Poppin' them puppies with a trode since 1989 *
Our laboratory is
located in the Department of
Molecular and Cellular Physiology, Beckman Center for Molecular and
Genetic Medicine
at the Stanford University
School of Medicine.
The School of Medicine is located on the main campus of Stanford
University in Palo
Alto, CA, in the San Francisco
Bay Area.
Phone: 650-725-7563
FAX: 650-618-2779
Email - Business: madison "at" stanford "dot" edu
Personal: DVMadison "at" gmail "dot"
com
Mailing Address: Beckman Center Rm B003, Stanford University School of Medicine, Stanford, CA 94305-5345 USA
Daniel Madison,
Ph.D. , Principal Investigator (madison@stanford.edu)
Fearless Leader
(which one???)
Our laboratory uses
electrophysiological techniques to study the mechanisms of synaptic
transmission
and plasticity in the mammalian hippocampus. One of the main focuses in
the lab is in the
study of
synaptic long-term potentiation (LTP). LTP is the persistent increase
in synaptic strength
that occurs
after a period of heavy activity in a synaptic connection. It is the
most widely studied
and compelling
model for mechanisms underlying memory formation in the mammalian
central nervous system.
Most
recently, we have been involved in studies of LTP that occurs between
individual pairs of
neurons.
The other major focus of the lab is the study of the modulation and
short term plasticity
of inhibitory
synaptic transmission in the hippocampus by different neurotransmitter
systems. Projects
under this
focus include studies on the modulatory properties of norepinephrine,
acetylcholine and
opiates on
hippocampal inhibitory circuitry and transmitter release.
Studies in the lab are carried out using a full range of
electrophysiological techniques
including
extracellular field potential recording, intracellular recording,whole
cell and single
channel recording in
hippocampal slices and cultured neurons.
Science Animations
Continuum Model of Synaptic Plasticity
State-Model of Synaptic Plasticity
Introduction to the Preparation
Teaching stuff (powerpoints, etc.):
Introduction to the Hippocampus
The origin of the membrane potential
The ionic basis of the action potential
Action Potential Conduction and Basis of synaptic transmission
Introduction to sensory transduction
Fun Stuff........
The Madison Lab and the Search for the Holy Grail on the Madison Lab Renovation
This
page is now archived. It will no longer be updated. For the current
version of the Madison Lab Web Page, please go to
http://www.stanford.edu/~madison/madlab
Last update:11/04/11
[an error occurred while processing this directive]
Get a GoStats hit counter