Wntless/Evi/Sprinter/Mig-14/Gpr177 (December 2009)
Based on original genetic evidence in Drosophila and C.elegans, the secretion of Wnt proteins needs the function of a dedicated protein Wntless (Wls) also known under various different other names (Evi/Sprinter/Mig-14/Gpr177; see table below). The Wls protein is a multiple-pass transmembrane molecule. Because of the lack of Wnt secretion in Wls mutant cells, it is thought that Wls is a transporter molecule that is specific for Wnt proteins. The gene is highly conserved and has been found in organisms ranging from mice to Planaria.
Review by Ching and Nusse, 2009
|C. elegans||mig-14||loss Wnt signaling (Yang, 2008)|
|Drosophila||Wntless/Evi/Sprinter||segment polarity (Banziger, 2006; Bartscherer, 2006; Goodman, 2006).|
|Mouse||Gpr177||early axis defect (Fu 2009)|
|Planaria||Smed-Evi/Wntless||regeneration defects (Adell, 2009)|