Updated December 2009

Mouse Wnt genes

There are 19 Wnt genes in the mouse genome.

Most genes linked to MGI, Mouse Genome Informatics. See the comparative table of all vertebrate Wnt genes for and explanation of the numbering/nomenclature. There is a separate table for syntenic linkage groups. Also, see alignments of many Wnt proteins

 gene  natural allele  Phenotype of Knockouts or other functions
Wnt1
(previously called int-1)

 

swaying
Thomas, 1991
Wnt2
(previously called irp)
 
Wnt2b/13  
Wnt3  
Wnt3a
 vestigial
tail Greco 1996
 Wnt4  
Wnt5a  
Wnt5b    
Wnt6    
Wnt7a
 postaxial hemimelia
Parr 1998
  • limb polarity (Parr 1995)
  • female infertility; failure regression of the Mullerian duct because the receptor for Mullerian-inhibiting substance is not expressed. Parr 1998
  • maintenance appropriate uterine patterning during the development of the mouse female reproductive tract (Miller 1998)
  • Delayed maturation synapses in Cerebellum (Hall, 2000)
  • High levels cell death in response to DES in the Female Reproductive Tract (Carta L, Sassoon D, 2004)
  • May promote neuronal differentiation (Hirabayashi 2004)
  • CNS vasculature (with Wnt7b, Stenman 2008)
Wnt7b  
Wnt8a    
Wnt8b  
  • ┬áLoss of function mutant: no effect on neural development, but changes in gene expression. (Fotaki, 2009)
Wnt9a

(prev. Wnt14)

  • Loss of function mutant: Joint integrity (Spater 2006)
Wnt9b

(prev. Wnt15)

Wnt10a    
Wnt10b  
Wnt11  
Wnt16    Activated by E2A-Pbx1 fusion protein in Pre-B ALL McWhirter 1999