Code Funding Group News NPSL Home Publications Prof. Shenoy Talks

Updated: 24 February 2017

Our group conducts (1) neuroscience, (2) neuroengineering, and (3) translational research to better understand how the brain controls movement, 
and to design medical systems to assist people with paralysis.

(1) Neuroscience.  Our neuroscience research investigates the neural basis of movement preparation and generation using a combination of
electro- / opto-physiological (e.g., chronic electrode-array recordings and optogenetic stimulation), behavioral, computational and theoretical techniques 
(e.g., dynamical systems, dimensionality reduction, single-trial neural analyses). For example, how do neurons in premotor (PMd) and primary motor (M1)
cortex plan and guide reaching arm movements?

Churchland et al. (2006) J Neurosci                  Churchland*, Yu* et al. (2010) Nature Neurosci          Churchland*, Cunningham* et al. (2012) Nature

(2) Neuroengineering.  Our neuroengineering research investigates the design of high-performance and robust neural prostheses. Neural prostheses 
are also known as brain-computer interfaces (BCIs) and brain-machine interfaces (BMIs). These systems translate neural activity from the brain into 
control signals for prosthetic devices, which can assist people with paralysis by restoring lost motor functions. This work includes statistical signal 
processing, machine learning, and real-time system modeling and implementation. For example, how can we design motor prostheses with 
performance rivaling the natural arm, or communication prostheses rivaling the throughput of spoken language?

 Gilja*, Nuyujukian* et al. (2012) Nature Neurosci          Nuyujukian et al. (2015) IEEE TBME                                  Nuyujukian et al. (2016) Proc. IEEE

(3) Translational.  Our translational research, including an FDA pilot clinical trial (BrainGate2), are conducted as part of the the Neural Prosthetic
Translational Laboratory (NPTL). For example, how do pre-clinical laboratory designs actually work with people with paralysis in real-world settings?


Blabe et al. (2015) J Neural Eng          Gilja*, Pandarinath* et al. (2015) Nature Medicine                   Pandarinath*, Nuyujukian* et al. (2017) eLife