The Personal Website of

Ph. D. in Systems Biology (2012 – 2018)

Harvard University

Neurobiology Summer Course (2014)

Marine Biological Laboratory

S. B. in Physics, Minor in Biology (2009 – 2012)

Massachusetts Institute of Technology

Transferred after Freshman Year (2008 – 2009)

Peking University

Coming from Wuhan, China


10. “Three-Dimensional Genome Structures of Single Sensory Neurons in Mouse Visual and Olfactory Systems.” Longzhi Tan*, Dong Xing*, Nicholas Daley, X. Sunney Xie. Nat Struct Mol Biol (2019) Link PDF SI Cover News & View Nature Feature

9. “Three-Dimensional Genome Structures of Single Diploid Human Cells.” Longzhi Tan*, Dong Xing*, Chi-Han Chang, Heng Li, X. Sunney Xie. Science (2018) Link PDF SI GitHub (dip-c, hickit) Nat Struct Mol Biol News & View Nat Methods Highlight Nature Feature

8. “A Near-Complete Spatial Map of Olfactory Receptors in the Mouse Main Olfactory Epithelium.” Longzhi Tan, X. Sunney Xie. Chem Senses (2018) Link PDF SI Cover Chem Senses Highlight

7. “Single-Cell Whole Genome Analyses by Linear Amplification via Transposon Insertion (LIANTI).” Chongyi Chen*, Dong Xing*, Longzhi Tan*, Heng Li*, Guangyu Zhou, Lei Huang, X. Sunney Xie. Science (2017) Link PDF SI GitHub

6. “Olfactory Sensory Neurons Transiently Express Multiple Olfactory Receptors during Development.” Longzhi Tan*, Qian Li*, X. Sunney Xie. Molecular Systems Biology (2015) Link PDF SI Nat Chem Biol Highlight

5. “Single Cell Transcriptome Amplification with MALBAC.” Alec R. Chapman*, Zi He*, Sijia Lu*, Jun Yong*, Longzhi Tan, Fuchou Tang, X. Sunney Xie. PLOS ONE (2015) Link PDF SI

4. “Rare Event of Histone Demethylation Can Initiate Singular Gene Expression of Olfactory Receptors.” Longzhi Tan, Chenghang Zong†, X. Sunney Xie†. PNAS (2013) Link PDF SI

3. “Modeling Recent Human Evolution in Mice by Expression of a Selected EDAR Variant.” Yana G. Kamberov*, Sijia Wang*, Jingze Tan, Pascale Gerbault, Abigail Wark, Longzhi Tan, Yajun Yang, Shilin Li, Kun Tang, Hua Chen, Adam Powell, Yuval Itan, Dorian Fuller, Jason Lohmueller, Junhao Mao, Asa Schachar, Madeline Paymer, Elizabeth Hostetter, Elizabeth Byrne, Melissa Burnett, Andrew P. McMahon, Mark G. Thomas, Daniel E. Lieberman†, Li Jin†, Clifford J. Tabin†, Bruce A. Morgan†, Pardis C. Sabeti†. Cell (2013) Link PDF Cover Video NYTimes Nat Rev Genet Highlight

2. “Slowly Switching between Environments Facilitates Reverse Evolution in Small Populations.” Longzhi Tan and Jeff Gore. Evolution (2012) Link PDF

1. “Hidden Randomness between Fitness Landscapes Limits Reverse Evolution.” Longzhi Tan*, Stephen Serene*, Hui Xiao Chao, Jeff Gore. Physical Review Letters (2012) Link PDF SI MITnews