Psychology 121/228
Across the Membrane
ION TRANSPORT & INTRACELLULAR MESSENGERS 

Text: Hille: Ionic Channels of Excitable Membranes, 3rd Edition 
Please read the highlighted chapters.  Quiz 2: 1, 10, 11; Quiz 3: 3, 6, 8;  Quiz 4: 7, 9

I. Classical Description of Channels • 

1.  Introduction • 
2.  Classical Biophysics of the Squid Giant Axon • 

3.  The Superfamily of Votage-Gated Channels• 
4.  Votage-Gated Calcium Channels • 
5.  Potassium Channels and Chloride Channels • 
6.  Ligand-Gated Channels of fast chemical synapses • 
7.  Modulation, Slow Synaptic Action,  2nd Messengers
8.  Sensory Transduction and excitable cells •
9.  Calcium Dynamics, Epithelial Transport, and Intercellular Coupling •
....  (portions only)

II. Principles & Mechanisms of Function •

10. Elementary Properties of lons in Solution •
11. Elementary Properties of Pores • 
12. Counting Channels • 
13. Structure of Channel Proteins
14. Selective Permeability: Independence •
15. Selective Permeability: Saturation and Binding 
16. Mechanisms of Block • 
17. Structure and Function studies of Permeation & Block • 
18. Gating Mechanisms • 
19. Gating: voltage sensing and inactivation
20. Modifiers of Gating • 
21. Cell Biology and Channels • 
22.  Evolution and Origins • 

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