| Psychology 121 or 228*
Across the Membrane J. Wine [last edit 3/3/2021] |
Syllabus |
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* ion movements in excitable and
non-excitable cells;
* aspects of the plasma
membrane relevant to signaling;
* general features of
ion transport;
* identification of ion
pumps and ion transporters;
* molecular properties
of ion channels, carriers, and pumps;
* receptor and voltage
gated ion channels;
* regulation of ion
channels by intracellular messengers;
* transport of
macromolecules;
* roles of ion transport
in human genetic disease
The informal title of the course
is "Across the Membrane" to emphasize that most of the topics
will deal with the physical movement
of substances across the plasma membrane of cells.
However, we will also deal with the more subtle movement of
information across cells that occurs with G protein-linked
receptors.
Topics not covered include those signaling pathways used
primarily for growth, differentiation, and development,
for example as mediated by cytosolic hormonal receptors,
growth factors, tyrosine kinase pathways, etc.
The much broader topics in the Consilience
part of the course can be gleaned from its subtitle: The
Unity of Knowledge,
and from Wilson's chapter headings: The Ionian
Enchantment, The Great Branches of Learning, The
Enlightenment, The Natural Sciences,
Ariadne's Thread, The Mind, From Genes to Culture, and The
Fitness of Human Nature.
* Note: Graduate students should sign up for 228.
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| Jeff Wine |
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by appt. |
wine@stanford.edu |
| Sarah
Ludington |
email
or zoom
by appt. |
sarahl21@stanford.edu |
1. The main
readings are notes, original
articles that will be available online, and Wilson: Consilience.
2. Required text:
Consilience: The Unity of Knowledge, E. O. Wilson. I recommend
that Kindle edition ($14.99).
3. Recommended text: Hille: Ion Channels of
Excitable Membranes, Third Edition
In addition to copies that will be put on
reserve, you should be able to find this text online.
* Alberts, et al.: Molecular
Biology of the Cell, 7th
Edition.
* Berg, Tymoczko &
Stryer: Biochemistry
These
texts are more detailed and quantitative than our discussions
and quizzes will be in class,
but many students may prefer and be more comfortable with the
quantitative treatment.
The search feature is useful for unfamiliar terms.
Many articles and texts are
available via PubMed.
Default
is PubMed searching, but try the pull down menu for other
choices, such as books.
And of course, Google and Wikipedia are becoming
indispensable.
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