Psychology 121 or 228*
Across the Membrane
J. Wine
[last edit 3/3/2021] 
Syllabus
Home Schedule Wine
 
ION TRANSPORT & INTRACELLULAR MESSENGERS 
Monday 5:30-7:30    Via Zoom in 2021  Room 419, Bldg. 420 Jane Stanford Way (Map)
Scope of course
Mechanics of the course
Exams & Grading Paper
Staff
Readings
Web site
Schedule
Letters of Recommendation


Scope of course The course has two components: one more philosophical, and the other technical. 
For the philosophical component we will read and discuss Consilience, by E. O. Wilson--at least the first 8 chapters.
The hope is that by doing so, the molecular and cellular science that will take up most of our time will be put in a broader context--
how broad is a question we will discuss but not answer in the definitive way in which the molecular and cellular questions can be answered.

Communication between and within cells is mediated by electrical and chemical signals. 
A great deal has been learned about these processes. 
In the last decades we have seen a major increment in our understanding of transport,
because of our ability to know and manipulate the individual molecular structures responsible for transport. 
Topics in this course will include:

* ion movements in excitable and non-excitable cells;
* aspects of the plasma membrane relevant to signaling;
* general features of ion transport;
* identification of ion pumps and ion transporters;
* molecular properties of ion channels, carriers, and pumps;
* receptor and voltage gated ion channels;
* regulation of ion channels by intracellular messengers;
* transport of macromolecules;
* roles of ion transport in human genetic disease

The informal title of the course is "Across the Membrane" to emphasize that most of the topics will deal with the physical movement
of substances across the plasma membrane of cells. 
However, we will also deal with the more subtle movement of information across cells that occurs with G protein-linked receptors. 
Topics not covered include those signaling pathways used primarily for growth, differentiation, and development,
for example as mediated by cytosolic hormonal receptors, growth factors, tyrosine kinase pathways, etc.

The much broader topics in the Consilience part of the course can be gleaned from its subtitle: The Unity of Knowledge,
and from Wilson's chapter headings: The Ionian Enchantment, The Great Branches of Learning, The Enlightenment, The Natural Sciences,
Ariadne's Thread, The Mind, From Genes to Culture, and The Fitness of Human Nature.



Mechanics of the course The course will be taught via Zoom.  The lectures are recorded so you can view them any time before class. 
In class, we will discuss the lectures and readings, structured with sets of questions or discussion points.  
I will hold individual discussions with you as requested via zoom or email. 
We will use breakout rooms so you can discuss the questions with one another in depth, and I'll drop in and out.

Grading*. For this online class, grades will be based on engagement with the material, as judged by viewing of recorded lectures,
completion of feedback assignments, and discussions during zoom class sessions/individual sessions. 
The expected grade range will be narrow, A+ for exceptional effort to B- for acceptable effort. 
Failure is possible, but not expected; it occurs when students disengage but don't formally withdraw. 
If you are having difficulties that could cause an unwelcome outcome, let us know!  

How could you end up with NC?  Missing 2 assignments OR 2 classes without prior arrangement.   

* Note: Graduate students should sign up for 228.



Staff
name
room
Office hours
e-mail
Jeff Wine
Jordan 450
 email or zoom
by appt.
wine@stanford.edu
Sarah Ludington

email or zoom
by appt.
sarahl21@stanford.edu


Readings  You won't be held for any readings that we can't make accessible online. 
For an overview of channels and ions try Hille.

1.  The main readings are notes,  original articles that will be available online, and Wilson: Consilience. 
2.  Required text: Consilience: The Unity of Knowledge, E. O. Wilson. I recommend that Kindle edition ($14.99).
3.  Recommended text: Hille:  Ion Channels of Excitable Membranes, Third Edition 
In addition to copies that will be put on reserve, you should be able to find this text online.

If you don't own one of the following texts, and if you will do further work in the general areas discussed in class, you might consider buying or borrowing a copy;
these books are also available for searching (but not reading) on line:

* Alberts, et al.:  Molecular Biology of the Cell, 7th Edition. 
* Berg, Tymoczko & Stryer:  Biochemistry

These texts are more detailed and quantitative than our discussions and quizzes will be in class,
but many students may prefer and be more comfortable with the quantitative treatment.  
The search feature is useful for unfamiliar terms.

Many articles and texts are available via PubMed.   Default is PubMed searching, but try the pull down menu for other choices, such as books. 
And of course, Google and Wikipedia are becoming indispensable.



Website.  The website is designed to provide you with flexibility in reviewing notes and keeping track of what is going on in the course. 
Please let me know (wine@stanford.edu) about any problems with the pages. 
A  problem is the paucity and quality of graphics.


Home Schedule Wine