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Lithium aluminum hydride
(LAH, lithium tetrahydroaluminate)
CAS 16853-85-3 |
LiAlH4 |
White to gray crystalline solid
Decomposes above 125 ° C
Reacts vigorously with water |
Odorless solid |
Ignites in moist or heated air |
TLV-TWA (ACGIH) 2 mg (Al)/m 3 |
Reacts violently with water, acids, and many oxygenated compounds; may ignite in moist air; corrosive to skin, eyes, and mucous membranes. |
Lithium aluminum hydride is highly corrosive to the skin, eyes, and mucous membranes. Contact with moisture forms lithium hydroxide, which can cause severe burns. Powdered LAH forms dusts that can pose an inhalation hazard. Ingestion of this substance may cause aching muscles, nausea, vomiting, dizziness, and unconsciousness and may be fatal. Ingestion can result in gas embolism due to the formation of hydrogen. No chronic effects of lithium aluminum hydride have been identified. |
Lithium aluminum hydride is a highly flammable solid and may ignite in moist or heated air. Exposure to water results in the release of hydrogen, which can be ignited by the heat from the exothermic reaction. Lithium aluminum hydride should not be used as a drying agent for solvents because fires can easily result (LAH decomposes at about 125 ° C, a temperature easily reached at a flask's surface in a heating mantle). The decomposition products of LAH can be quite explosive, and the products of its reaction with carbon dioxide have been reported to be explosive. Use dry chemical powder or sand to extinguish fires involving lithium aluminum hydride. Never use water or carbon dioxide extinguishers on an LAH fire. |
Lithium aluminum hydride reacts violently with water, acids, oxidizers, alcohols, and many oxygenated organic compounds, including, in particular, peroxides, hydroperoxides, and peracids. LAH reacts with many metal halides to produce metal hydride products, which are flammable and toxic. |
Lithium aluminum hydride should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C, supplemented by the additional precautions for work with flammable (Chapter 5.F) and reactive (Chapter 5.G) substances. In particular, LAH should be handled in areas free of ignition sources under an inert atmosphere. Safety glasses, impermeable gloves, and a fire-retardant laboratory coat are required. A dry powder fire extinguisher or pail of sand (and shovel) must be available in areas where LAH is to be handled or stored. Work with large quantities of powdered LAH should be conducted in a fume hood under an inert gas such as nitrogen or argon. Lithium aluminum hydride should be stored in tightly sealed containers in a cool, dry area separate from combustible materials. Dry LAH powder should never be exposed to water or moist air. Lithium aluminum hydride can be a finely powdered reagent that produces a reactive dust on handling. The older practice of grinding lithium aluminum hydride prior to use can cause explosions and should not be employed. |
In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention. If lithium aluminum hydride is ingested, obtain medical attention immediately. If large amounts of LAH dust are inhaled, move the person to fresh air and seek medical attention at once. In the event of a spill, instruct others to maintain a safe distance; while wearing a face shield and goggles, laboratory coat, and butyl rubber gloves, cover the spilled material with sand. Scoop the resulting mixture into a container suitable for treatment or disposal as discussed below. |
Small amounts of excess LAH can be destroyed by forming a suspension or solution in an inert solvent such as diethyl ether or hexane, cooling in an ice bath, and slowly and carefully adding ethyl acetate dropwise with stirring. This is followed by the addition of a saturated aqueous solution of ammonium chloride. Excess lithium aluminum hydride and the products of the treatment described above should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. For more information on disposal procedures, see Chapter 7. |
The information in this LCSS has been compiled by a committee
of the National Research Council from literature sources and Material
Safety Data Sheets and is believed to be accurate as of July 1994.
This summary is intended for use by trained laboratory personnel
in conjunction with the NRC report Prudent
Practices in the Laboratory: Handling and Disposal of Chemicals. This LCSS presents a concise
summary of safety information that should be adequate for most
laboratory uses of the title substance, but in some cases it may
be advisable to consult more comprehensive references. This information
should not be used as a guide to the nonlaboratory use of this
chemical.
Copyright 1995 National Academy of Sciences. All rights reserved.
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