Solution:

if d/dt(q1) = k12(q2) - k21(q1) and d/dt(q2) = k21(q1) - k12(q2), then

where  c1,c2, c3, & c4 and d1, d2, d3, & d4 = f(k12, k21) and the initial conditions.

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B.3-b