Repetitive Extravascular Dosing

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Example:

In a single IM dose of kanamycin, we obtain the following information: (F=1.0 complete absorption), V_d = 30L, and k_el=0.4 hr^-1, and the time of the peak is about 1.0hr (k_a=4.0hr^-1)  If 600-mg doses of kanamycin are administered IM every 4 hr, what will C_max and C_min be when the plasma [ ] plateau is reached?

Solution

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B.9c-3