Participating Labs

The labs in the Stanford Center for Cell Biology are housed in the Biology Department, and are conducting research on a broad range of interesting and important cell biology areas:

 

Cyert Lab  – cell signaling

Dixon Lab – cell death & metabolism

Feldman Lab – cell  & cytoskeletal patterning

Kopito Lab – protein folding and destruction

Skotheim Lab – systems biology, cell cycle

Stearns Lab – centrosomes, cilia & the cell cycle

Ting Lab – mapping cells and functional circuits

 

 

Recent Publications

  1. Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P et al.. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018; :. doi: 10.1038/s41418-017-0012-4. PubMed PMID:29362479 .
  2. Schwarz, C, Johnson, A, Kõivomägi, M, Zatulovskiy, E, Kravitz, CJ, Doncic, A et al.. A Precise Cdk Activity Threshold Determines Passage through the Restriction Point. Mol. Cell. 2018;69 (2):253-264.e5. doi: 10.1016/j.molcel.2017.12.017. PubMed PMID:29351845 PubMed Central PMC5790185.
  3. Tarangelo, A, Magtanong, L, Bieging-Rolett, KT, Li, Y, Ye, J, Attardi, LD et al.. p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Rep. 2018;22 (3):569-575. doi: 10.1016/j.celrep.2017.12.077. PubMed PMID:29346757 PubMed Central PMC5791910.
  4. Inde, Z, Dixon, SJ. The impact of non-genetic heterogeneity on cancer cell death. Crit. Rev. Biochem. Mol. Biol. 2018;53 (1):99-114. doi: 10.1080/10409238.2017.1412395. PubMed PMID:29250983 .
  5. Kaewsapsak, P, Shechner, DM, Mallard, W, Rinn, JL, Ting, AY. Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking. Elife. 2017;6 :. doi: 10.7554/eLife.29224. PubMed PMID:29239719 PubMed Central PMC5730372.
  6. Kim, MW, Wang, W, Sanchez, MI, Coukos, R, von Zastrow, M, Ting, AY et al.. Time-gated detection of protein-protein interactions with transcriptional readout. Elife. 2017;6 :. doi: 10.7554/eLife.30233. PubMed PMID:29189201 PubMed Central PMC5708895.
  7. Stratton, M, Stearns, T. Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation. Dev. Cell. 2017;43 (4):385-386. doi: 10.1016/j.devcel.2017.11.001. PubMed PMID:29161589 .
  8. Han, S, Li, J, Ting, AY. Proximity labeling: spatially resolved proteomic mapping for neurobiology. Curr. Opin. Neurobiol. 2017;50 :17-23. doi: 10.1016/j.conb.2017.10.015. PubMed PMID:29125959 .
  9. Ligibel, JA, Alfano, CM, Hershman, DL, Merrill, JK, Basen-Engquist, K, Bloomgarden, ZT et al.. American Society of Clinical Oncology Summit on Addressing Obesity Through Multidisciplinary Provider Collaboration: Key Findings and Recommendations for Action. Obesity (Silver Spring). 2017;25 Suppl 2 :S34-S39. doi: 10.1002/oby.21987. PubMed PMID:29086516 .
  10. Udeshi, ND, Pedram, K, Svinkina, T, Fereshetian, S, Myers, SA, Aygun, O et al.. Antibodies to biotin enable large-scale detection of biotinylation sites on proteins. Nat. Methods. 2017;14 (12):1167-1170. doi: 10.1038/nmeth.4465. PubMed PMID:29039416 .
  11. Stockwell, BR, Friedmann Angeli, JP, Bayir, H, Bush, AI, Conrad, M, Dixon, SJ et al.. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171 (2):273-285. doi: 10.1016/j.cell.2017.09.021. PubMed PMID:28985560 PubMed Central PMC5685180.
  12. Abudayyeh, OO, Gootenberg, JS, Essletzbichler, P, Han, S, Joung, J, Belanto, JJ et al.. RNA targeting with CRISPR-Cas13. Nature. 2017;550 (7675):280-284. doi: 10.1038/nature24049. PubMed PMID:28976959 PubMed Central PMC5706658.
  13. Wang, JT, Kong, D, Hoerner, CR, Loncarek, J, Stearns, T. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Elife. 2017;6 :. doi: 10.7554/eLife.29061. PubMed PMID:28906251 PubMed Central PMC5653238.
  14. Chandler-Brown, D, Schmoller, KM, Winetraub, Y, Skotheim, JM. The Adder Phenomenon Emerges from Independent Control of Pre- and Post-Start Phases of the Budding Yeast Cell Cycle. Curr. Biol. 2017;27 (18):2774-2783.e3. doi: 10.1016/j.cub.2017.08.015. PubMed PMID:28889980 PubMed Central PMC5679121.
  15. Wu, S, Fagan, RR, Uttamapinant, C, Lifshitz, LM, Fogarty, KE, Ting, AY et al.. The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach. J. Neurosci. 2017;37 (39):9438-9452. doi: 10.1523/JNEUROSCI.3885-16.2017. PubMed PMID:28847807 PubMed Central PMC5618262.
  16. Bond, R, Ly, N, Cyert, MS. The unique C terminus of the calcineurin isoform CNAβ1 confers non-canonical regulation of enzyme activity by Caand calmodulin. J. Biol. Chem. 2017;292 (40):16709-16721. doi: 10.1074/jbc.M117.795146. PubMed PMID:28842480 PubMed Central PMC5633132.
  17. Jukam, D, Shariati, SAM, Skotheim, JM. Zygotic Genome Activation in Vertebrates. Dev. Cell. 2017;42 (4):316-332. doi: 10.1016/j.devcel.2017.07.026. PubMed PMID:28829942 PubMed Central PMC5714289.
  18. Winter, ES, Schwarz, A, Fabig, G, Feldman, JL, Pires-daSilva, A, Müller-Reichert, T et al.. Cytoskeletal variations in an asymmetric cell division support diversity in nematode sperm size and sex ratios. Development. 2017;144 (18):3253-3263. doi: 10.1242/dev.153841. PubMed PMID:28827395 PubMed Central PMC5612256.
  19. Martell, JD, Deerinck, TJ, Lam, SS, Ellisman, MH, Ting, AY. Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells. Nat Protoc. 2017;12 (9):1792-1816. doi: 10.1038/nprot.2017.065. PubMed PMID:28796234 .
  20. Wang, W, Wildes, CP, Pattarabanjird, T, Sanchez, MI, Glober, GF, Matthews, GA et al.. A light- and calcium-gated transcription factor for imaging and manipulating activated neurons. Nat. Biotechnol. 2017;35 (9):864-871. doi: 10.1038/nbt.3909. PubMed PMID:28650461 PubMed Central PMC5595644.
  21. Conlon, M, Dixon, SJ. Ferroptosis-like death in plant cells. Mol Cell Oncol. 2017;4 (3):e1302906. doi: 10.1080/23723556.2017.1302906. PubMed PMID:28616580 PubMed Central PMC5462507.
  22. Forcina, GC, Conlon, M, Wells, A, Cao, JY, Dixon, SJ. Systematic Quantification of Population Cell Death Kinetics in Mammalian Cells. Cell Syst. 2017;4 (6):600-610.e6. doi: 10.1016/j.cels.2017.05.002. PubMed PMID:28601558 PubMed Central PMC5509363.
  23. Dixon, SJ. Ferroptosis: bug or feature?. Immunol. Rev. 2017;277 (1):150-157. doi: 10.1111/imr.12533. PubMed PMID:28462529 .
  24. Hwang, J, Walczak, CP, Shaler, TA, Olzmann, JA, Zhang, L, Elias, JE et al.. Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1. J. Biol. Chem. 2017;292 (22):9104-9116. doi: 10.1074/jbc.M117.785055. PubMed PMID:28411238 PubMed Central PMC5454095.
  25. Lobingier, BT, Hüttenhain, R, Eichel, K, Miller, KB, Ting, AY, von Zastrow, M et al.. An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells. Cell. 2017;169 (2):350-360.e12. doi: 10.1016/j.cell.2017.03.022. PubMed PMID:28388416 PubMed Central PMC5616215.
  26. Yackle, K, Schwarz, LA, Kam, K, Sorokin, JM, Huguenard, JR, Feldman, JL et al.. Breathing control center neurons that promote arousal in mice. Science. 2017;355 (6332):1411-1415. doi: 10.1126/science.aai7984. PubMed PMID:28360327 PubMed Central PMC5505554.
  27. Eser, U, Chandler-Brown, D, Ay, F, Straight, AF, Duan, Z, Noble, WS et al.. Form and function of topologically associating genomic domains in budding yeast. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (15):E3061-E3070. doi: 10.1073/pnas.1612256114. PubMed PMID:28348222 PubMed Central PMC5393236.
  28. Sweeney, P, Park, H, Baumann, M, Dunlop, J, Frydman, J, Kopito, R et al.. Protein misfolding in neurodegenerative diseases: implications and strategies. Transl Neurodegener. 2017;6 :6. doi: 10.1186/s40035-017-0077-5. PubMed PMID:28293421 PubMed Central PMC5348787.
  29. Han, S, Udeshi, ND, Deerinck, TJ, Svinkina, T, Ellisman, MH, Carr, SA et al.. Proximity Biotinylation as a Method for Mapping Proteins Associated with mtDNA in Living Cells. Cell Chem Biol. 2017;24 (3):404-414. doi: 10.1016/j.chembiol.2017.02.002. PubMed PMID:28238724 .
  30. Distéfano, AM, Martin, MV, Córdoba, JP, Bellido, AM, D'Ippólito, S, Colman, SL et al.. Heat stress induces ferroptosis-like cell death in plants. J. Cell Biol. 2017;216 (2):463-476. doi: 10.1083/jcb.201605110. PubMed PMID:28100685 PubMed Central PMC5294777.
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