Participating Labs

The labs in the Stanford Center for Cell Biology are housed in the Biology Department, and are conducting research on a broad range of interesting and important cell biology areas:


Cyert Lab  – cell signaling

Dixon Lab – cell death & metabolism

Feldman Lab – cell  & cytoskeletal patterning

Kopito Lab – protein folding and destruction

Skotheim Lab – systems biology, cell cycle

Stearns Lab – centrosomes, cilia & the cell cycle

Ting Lab – mapping cells and functional circuits



Recent Publications

  1. Walczak, CP, Leto, DE, Zhang, L, Riepe, C, Muller, RY, DaRosa, PA et al.. Ribosomal protein RPL26 is the principal target of UFMylation. Proc. Natl. Acad. Sci. U.S.A. 2019; :. doi: 10.1073/pnas.1816202116. PubMed PMID:30626644 .
  2. Yoon, J, Comerci, CJ, Weiss, LE, Milenkovic, L, Stearns, T, Moerner, WE et al.. Revealing Nanoscale Morphology of the Primary Cilium Using Super-Resolution Fluorescence Microscopy. Biophys. J. 2018; :. doi: 10.1016/j.bpj.2018.11.3136. PubMed PMID:30598282 .
  3. Leto, DE, Morgens, DW, Zhang, L, Walczak, CP, Elias, JE, Bassik, MC et al.. Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Mol. Cell. 2018; :. doi: 10.1016/j.molcel.2018.11.015. PubMed PMID:30581143 .
  4. Smith, FD, Omar, MH, Nygren, PJ, Soughayer, J, Hoshi, N, Lau, HT et al.. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (49):E11465-E11474. doi: 10.1073/pnas.1816614115. PubMed PMID:30455320 PubMed Central PMC6298107.
  5. Ko, PJ, Dixon, SJ. Protein palmitoylation and cancer. EMBO Rep. 2018;19 (10):. doi: 10.15252/embr.201846666. PubMed PMID:30232163 PubMed Central PMC6172454.
  6. Vladar, EK, Stratton, MB, Saal, ML, Salazar-De Simone, G, Wang, X, Wolgemuth, D et al.. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018;7 :. doi: 10.7554/eLife.36375. PubMed PMID:30152757 PubMed Central PMC6145839.
  7. Branon, TC, Bosch, JA, Sanchez, AD, Udeshi, ND, Svinkina, T, Carr, SA et al.. Efficient proximity labeling in living cells and organisms with TurboID. Nat. Biotechnol. 2018;36 (9):880-887. doi: 10.1038/nbt.4201. PubMed PMID:30125270 PubMed Central PMC6126969.
  8. Pataki, CI, Rodrigues, J, Zhang, L, Qian, J, Efron, B, Hastie, T et al.. Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (35):E8172-E8180. doi: 10.1073/pnas.1807981115. PubMed PMID:30104359 PubMed Central PMC6126764.
  9. Sallee, MD, Zonka, JC, Skokan, TD, Raftrey, BC, Feldman, JL. Tissue-specific degradation of essential centrosome components reveals distinct microtubule populations at microtubule organizing centers. PLoS Biol. 2018;16 (8):e2005189. doi: 10.1371/journal.pbio.2005189. PubMed PMID:30080857 PubMed Central PMC6103517.
  10. Mirvis, M, Stearns, T, James Nelson, W. Cilium structure, assembly, and disassembly regulated by the cytoskeleton. Biochem. J. 2018;475 (14):2329-2353. doi: 10.1042/BCJ20170453. PubMed PMID:30064990 PubMed Central PMC6068341.
  11. Dovey, CM, Diep, J, Clarke, BP, Hale, AT, McNamara, DE, Guo, H et al.. MLKL Requires the Inositol Phosphate Code to Execute Necroptosis. Mol. Cell. 2018;70 (5):936-948.e7. doi: 10.1016/j.molcel.2018.05.010. PubMed PMID:29883610 PubMed Central PMC5994928.
  12. Tarangelo, A, Dixon, S. The p53-p21 pathway inhibits ferroptosis during metabolic stress. Oncotarget. 2018;9 (37):24572-24573. doi: 10.18632/oncotarget.25362. PubMed PMID:29872487 PubMed Central PMC5973850.
  13. van der Goot, AT, Pearce, MMP, Leto, DE, Shaler, TA, Kopito, RR. Redundant and Antagonistic Roles of XTP3B and OS9 in Decoding Glycan and Non-glycan Degrons in ER-Associated Degradation. Mol. Cell. 2018;70 (3):516-530.e6. doi: 10.1016/j.molcel.2018.03.026. PubMed PMID:29706535 PubMed Central PMC5935522.
  14. Bell, JC, Jukam, D, Teran, NA, Risca, VI, Smith, OK, Johnson, WL et al.. Chromatin-associated RNA sequencing (ChAR-seq) maps genome-wide RNA-to-DNA contacts. Elife. 2018;7 :. doi: 10.7554/eLife.27024. PubMed PMID:29648534 PubMed Central PMC5962340.
  15. Wang, JT, Stearns, T. The ABCs of Centriole Architecture: The Form and Function of Triplet Microtubules. Cold Spring Harb. Symp. Quant. Biol. 2017;82 :145-155. doi: 10.1101/sqb.2017.82.034496. PubMed PMID:29540555 .
  16. Galluzzi, L, Vitale, I, Aaronson, SA, Abrams, JM, Adam, D, Agostinis, P et al.. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25 (3):486-541. doi: 10.1038/s41418-017-0012-4. PubMed PMID:29362479 PubMed Central PMC5864239.
  17. Schwarz, C, Johnson, A, Kõivomägi, M, Zatulovskiy, E, Kravitz, CJ, Doncic, A et al.. A Precise Cdk Activity Threshold Determines Passage through the Restriction Point. Mol. Cell. 2018;69 (2):253-264.e5. doi: 10.1016/j.molcel.2017.12.017. PubMed PMID:29351845 PubMed Central PMC5790185.
  18. Tarangelo, A, Magtanong, L, Bieging-Rolett, KT, Li, Y, Ye, J, Attardi, LD et al.. p53 Suppresses Metabolic Stress-Induced Ferroptosis in Cancer Cells. Cell Rep. 2018;22 (3):569-575. doi: 10.1016/j.celrep.2017.12.077. PubMed PMID:29346757 PubMed Central PMC5791910.
  19. Inde, Z, Dixon, SJ. The impact of non-genetic heterogeneity on cancer cell death. Crit. Rev. Biochem. Mol. Biol. 2018;53 (1):99-114. doi: 10.1080/10409238.2017.1412395. PubMed PMID:29250983 PubMed Central PMC6089072.
  20. Kaewsapsak, P, Shechner, DM, Mallard, W, Rinn, JL, Ting, AY. Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking. Elife. 2017;6 :. doi: 10.7554/eLife.29224. PubMed PMID:29239719 PubMed Central PMC5730372.
  21. Kim, MW, Wang, W, Sanchez, MI, Coukos, R, von Zastrow, M, Ting, AY et al.. Time-gated detection of protein-protein interactions with transcriptional readout. Elife. 2017;6 :. doi: 10.7554/eLife.30233. PubMed PMID:29189201 PubMed Central PMC5708895.
  22. Stratton, M, Stearns, T. Mitosis sans Mitosis: The Mitotic Oscillator in Differentiation. Dev. Cell. 2017;43 (4):385-386. doi: 10.1016/j.devcel.2017.11.001. PubMed PMID:29161589 .
  23. Han, S, Li, J, Ting, AY. Proximity labeling: spatially resolved proteomic mapping for neurobiology. Curr. Opin. Neurobiol. 2018;50 :17-23. doi: 10.1016/j.conb.2017.10.015. PubMed PMID:29125959 .
  24. Ligibel, JA, Alfano, CM, Hershman, DL, Merrill, JK, Basen-Engquist, K, Bloomgarden, ZT et al.. American Society of Clinical Oncology Summit on Addressing Obesity Through Multidisciplinary Provider Collaboration: Key Findings and Recommendations for Action. Obesity (Silver Spring). 2017;25 Suppl 2 :S34-S39. doi: 10.1002/oby.21987. PubMed PMID:29086516 .
  25. Udeshi, ND, Pedram, K, Svinkina, T, Fereshetian, S, Myers, SA, Aygun, O et al.. Antibodies to biotin enable large-scale detection of biotinylation sites on proteins. Nat. Methods. 2017;14 (12):1167-1170. doi: 10.1038/nmeth.4465. PubMed PMID:29039416 .
  26. Stockwell, BR, Friedmann Angeli, JP, Bayir, H, Bush, AI, Conrad, M, Dixon, SJ et al.. Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease. Cell. 2017;171 (2):273-285. doi: 10.1016/j.cell.2017.09.021. PubMed PMID:28985560 PubMed Central PMC5685180.
  27. Abudayyeh, OO, Gootenberg, JS, Essletzbichler, P, Han, S, Joung, J, Belanto, JJ et al.. RNA targeting with CRISPR-Cas13. Nature. 2017;550 (7675):280-284. doi: 10.1038/nature24049. PubMed PMID:28976959 PubMed Central PMC5706658.
  28. Wang, JT, Kong, D, Hoerner, CR, Loncarek, J, Stearns, T. Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells. Elife. 2017;6 :. doi: 10.7554/eLife.29061. PubMed PMID:28906251 PubMed Central PMC5653238.
  29. Chandler-Brown, D, Schmoller, KM, Winetraub, Y, Skotheim, JM. The Adder Phenomenon Emerges from Independent Control of Pre- and Post-Start Phases of the Budding Yeast Cell Cycle. Curr. Biol. 2017;27 (18):2774-2783.e3. doi: 10.1016/j.cub.2017.08.015. PubMed PMID:28889980 PubMed Central PMC5679121.
  30. Wu, S, Fagan, RR, Uttamapinant, C, Lifshitz, LM, Fogarty, KE, Ting, AY et al.. The Dopamine Transporter Recycles via a Retromer-Dependent Postendocytic Mechanism: Tracking Studies Using a Novel Fluorophore-Coupling Approach. J. Neurosci. 2017;37 (39):9438-9452. doi: 10.1523/JNEUROSCI.3885-16.2017. PubMed PMID:28847807 PubMed Central PMC5618262.
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