Participating Labs

The labs in the Stanford Center for Cell Biology are housed in the Biology Department, and are conducting research on a broad range of interesting and important cell biology areas:


Cyert Lab  – cell signaling

Dixon Lab – cell death & metabolism

Feldman Lab – cell  & cytoskeletal patterning

Kopito Lab – protein folding and destruction

Skotheim Lab – systems biology, cell cycle

Stearns Lab – centrosomes, cilia & the cell cycle

Ting Lab – mapping cells and functional circuits



Recent Publications

  1. Pickett, MA, Naturale, VF, Feldman, JL. A Polarizing Issue: Diversity in the Mechanisms Underlying Apico-Basolateral Polarization In Vivo. Annu. Rev. Cell Dev. Biol. 2019; :. doi: 10.1146/annurev-cellbio-100818-125134. PubMed PMID:31461314 .
  2. Gottlieb, CD, Thompson, ACS, Ordureau, A, Harper, JW, Kopito, RR. Acute unfolding of a single protein immediately stimulates recruitment of ubiquitin protein ligase E3C (UBE3C) to 26S proteasomes. J. Biol. Chem. 2019; :. doi: 10.1074/jbc.RA119.009654. PubMed PMID:31375563 .
  3. Zhang, Y, Song, G, Lal, NK, Nagalakshmi, U, Li, Y, Zheng, W et al.. TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity. Nat Commun. 2019;10 (1):3252. doi: 10.1038/s41467-019-11202-z. PubMed PMID:31324801 PubMed Central PMC6642208.
  4. Mirvis, M, Siemers, KA, Nelson, WJ, Stearns, TP. Primary cilium loss in mammalian cells occurs predominantly by whole-cilium shedding. PLoS Biol. 2019;17 (7):e3000381. doi: 10.1371/journal.pbio.3000381. PubMed PMID:31314751 PubMed Central PMC6699714.
  5. Roy, J, Cyert, MS. Identifying New Substrates and Functions for an Old Enzyme: Calcineurin. Cold Spring Harb Perspect Biol. 2019; :. doi: 10.1101/cshperspect.a035436. PubMed PMID:31308145 .
  6. Nguyen, HQ, Roy, J, Harink, B, Damle, NP, Latorraca, NR, Baxter, BC et al.. Quantitative mapping of protein-peptide affinity landscapes using spectrally encoded beads. Elife. 2019;8 :. doi: 10.7554/eLife.40499. PubMed PMID:31282865 PubMed Central PMC6728138.
  7. Magescas, J, Zonka, JC, Feldman, JL. A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome. Elife. 2019;8 :. doi: 10.7554/eLife.47867. PubMed PMID:31246171 PubMed Central PMC6684319.
  8. Fazal, FM, Han, S, Parker, KR, Kaewsapsak, P, Xu, J, Boettiger, AN et al.. Atlas of Subcellular RNA Localization Revealed by APEX-Seq. Cell. 2019;178 (2):473-490.e26. doi: 10.1016/j.cell.2019.05.027. PubMed PMID:31230715 .
  9. Shariati, SA, Dominguez, A, Xie, S, Wernig, M, Qi, LS, Skotheim, JM et al.. Reversible Disruption of Specific Transcription Factor-DNA Interactions Using CRISPR/Cas9. Mol. Cell. 2019;74 (3):622-633.e4. doi: 10.1016/j.molcel.2019.04.011. PubMed PMID:31051141 PubMed Central PMC6599634.
  10. Nanjundappa, R, Kong, D, Shim, K, Stearns, T, Brody, SL, Loncarek, J et al.. Regulation of cilia abundance in multiciliated cells. Elife. 2019;8 :. doi: 10.7554/eLife.44039. PubMed PMID:31025935 PubMed Central PMC6504233.
  11. Topacio, BR, Zatulovskiy, E, Cristea, S, Xie, S, Tambo, CS, Rubin, SM et al.. Cyclin D-Cdk4,6 Drives Cell-Cycle Progression via the Retinoblastoma Protein's C-Terminal Helix. Mol. Cell. 2019;74 (4):758-770.e4. doi: 10.1016/j.molcel.2019.03.020. PubMed PMID:30982746 .
  12. Kim, CK, Cho, KF, Kim, MW, Ting, AY. Luciferase-LOV BRET enables versatile and specific transcriptional readout of cellular protein-protein interactions. Elife. 2019;8 :. doi: 10.7554/eLife.43826. PubMed PMID:30942168 PubMed Central PMC6447360.
  13. Leto, DE, Kopito, RR. Methods for genetic analysis of mammalian ER-associated degradation. Meth. Enzymol. 2019;619 :97-120. doi: 10.1016/bs.mie.2019.01.006. PubMed PMID:30910031 .
  14. Forcina, GC, Dixon, SJ. GPX4 at the Crossroads of Lipid Homeostasis and Ferroptosis. Proteomics. 2019;19 (18):e1800311. doi: 10.1002/pmic.201800311. PubMed PMID:30888116 .
  15. Maddox, AS, Skotheim, JM. Cell cycle, cell division, cell death. Mol. Biol. Cell. 2019;30 (6):732. doi: 10.1091/mbc.E18-12-0819. PubMed PMID:30870093 PubMed Central PMC6589781.
  16. Lo, YC, Cormier, O, Liu, T, Nettles, KW, Katzenellenbogen, JA, Stearns, T et al.. Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site. Nat Commun. 2019;10 (1):1033. doi: 10.1038/s41467-019-08965-w. PubMed PMID:30833575 PubMed Central PMC6399299.
  17. Magtanong, L, Dixon, SJ. Ferroptosis and Brain Injury. Dev. Neurosci. 2018;40 (5-6):382-395. doi: 10.1159/000496922. PubMed PMID:30820017 PubMed Central PMC6658337.
  18. Weiss, LE, Milenkovic, L, Yoon, J, Stearns, T, Moerner, WE. Motional dynamics of single Patched1 molecules in cilia are controlled by Hedgehog and cholesterol. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (12):5550-5557. doi: 10.1073/pnas.1816747116. PubMed PMID:30819883 PubMed Central PMC6431229.
  19. Cao, JY, Poddar, A, Magtanong, L, Lumb, JH, Mileur, TR, Reid, MA et al.. A Genome-wide Haploid Genetic Screen Identifies Regulators of Glutathione Abundance and Ferroptosis Sensitivity. Cell Rep. 2019;26 (6):1544-1556.e8. doi: 10.1016/j.celrep.2019.01.043. PubMed PMID:30726737 PubMed Central PMC6424331.
  20. Magtanong, L, Ko, PJ, To, M, Cao, JY, Forcina, GC, Tarangelo, A et al.. Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State. Cell Chem Biol. 2019;26 (3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. PubMed PMID:30686757 PubMed Central PMC6430697.
  21. Wang, W, Kim, CK, Ting, AY. Molecular tools for imaging and recording neuronal activity. Nat. Chem. Biol. 2019;15 (2):101-110. doi: 10.1038/s41589-018-0207-0. PubMed PMID:30659298 .
  22. Walczak, CP, Leto, DE, Zhang, L, Riepe, C, Muller, RY, DaRosa, PA et al.. Ribosomal protein RPL26 is the principal target of UFMylation. Proc. Natl. Acad. Sci. U.S.A. 2019;116 (4):1299-1308. doi: 10.1073/pnas.1816202116. PubMed PMID:30626644 PubMed Central PMC6347690.
  23. Yoon, J, Comerci, CJ, Weiss, LE, Milenkovic, L, Stearns, T, Moerner, WE et al.. Revealing Nanoscale Morphology of the Primary Cilium Using Super-Resolution Fluorescence Microscopy. Biophys. J. 2019;116 (2):319-329. doi: 10.1016/j.bpj.2018.11.3136. PubMed PMID:30598282 PubMed Central PMC6349968.
  24. Leto, DE, Morgens, DW, Zhang, L, Walczak, CP, Elias, JE, Bassik, MC et al.. Genome-wide CRISPR Analysis Identifies Substrate-Specific Conjugation Modules in ER-Associated Degradation. Mol. Cell. 2019;73 (2):377-389.e11. doi: 10.1016/j.molcel.2018.11.015. PubMed PMID:30581143 PubMed Central PMC6338494.
  25. Smith, FD, Omar, MH, Nygren, PJ, Soughayer, J, Hoshi, N, Lau, HT et al.. Single nucleotide polymorphisms alter kinase anchoring and the subcellular targeting of A-kinase anchoring proteins. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (49):E11465-E11474. doi: 10.1073/pnas.1816614115. PubMed PMID:30455320 PubMed Central PMC6298107.
  26. Ko, PJ, Dixon, SJ. Protein palmitoylation and cancer. EMBO Rep. 2018;19 (10):. doi: 10.15252/embr.201846666. PubMed PMID:30232163 PubMed Central PMC6172454.
  27. Vladar, EK, Stratton, MB, Saal, ML, Salazar-De Simone, G, Wang, X, Wolgemuth, D et al.. Cyclin-dependent kinase control of motile ciliogenesis. Elife. 2018;7 :. doi: 10.7554/eLife.36375. PubMed PMID:30152757 PubMed Central PMC6145839.
  28. Branon, TC, Bosch, JA, Sanchez, AD, Udeshi, ND, Svinkina, T, Carr, SA et al.. Efficient proximity labeling in living cells and organisms with TurboID. Nat. Biotechnol. 2018;36 (9):880-887. doi: 10.1038/nbt.4201. PubMed PMID:30125270 PubMed Central PMC6126969.
  29. Pataki, CI, Rodrigues, J, Zhang, L, Qian, J, Efron, B, Hastie, T et al.. Proteomic analysis of monolayer-integrated proteins on lipid droplets identifies amphipathic interfacial α-helical membrane anchors. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (35):E8172-E8180. doi: 10.1073/pnas.1807981115. PubMed PMID:30104359 PubMed Central PMC6126764.
  30. Sallee, MD, Zonka, JC, Skokan, TD, Raftrey, BC, Feldman, JL. Tissue-specific degradation of essential centrosome components reveals distinct microtubule populations at microtubule organizing centers. PLoS Biol. 2018;16 (8):e2005189. doi: 10.1371/journal.pbio.2005189. PubMed PMID:30080857 PubMed Central PMC6103517.
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