Lab interests

The long term goal of our research is to understand how proteins fold in living cells. The Frydman lab uses a multidisciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation. In addition to basic mechanistic principles, we aim to define how impairment of cellular folding and quality control are linked to disease, including cancer, neurodegenerative disease and virus infection. We also examine how reengineering chaperone networks can provide therapeutic strategies.


Function and mechanism of the eukaryotic chaperonin TRiC

Chaperone networks, ribosome biogenesis and co-translational folding

Protein homeostasis, quality-control and selective degradation

Misfolding and Aggregation Diseases