2016-present

297. Jun, Y. W.; Wilson, D. L.; Kietrys, A. M.; Lotsof, E. R.; Conlon, S. G.; David, S. S.; Kool, E. T. An Excimer Clamp for Measuring Damaged Base Excision by the DNA Repair Enzyme NTH1. Angew. Chem. Int. Ed. 2020. Just Accepted.

296. Habibian, M. M.; Mckinlay, C. J.; Blake, T. R.; Waymouth, R.; Kietrys, A. M.; Wender, P.; Kool, E. Reversible RNA Acylation for Control of CRISPR-Cas9 Gene Editing. Chem. Sci. 2019. 11, 1011-1016.

295. Wilson, D. L.; Kool, E. T.,* Ultrafast Oxime Formation Enables Efficient Fluorescence Light-up Measurement of DNA Base Excision. J. Am. Chem. Soc. 2019. 141, 49, 19379-19388 .

294. Jun, Y. W.; Hebenbrock, M.; Kool, E.T.,* A Fluorescent Hydrazone Exchange Probe of Pyridoxal Phosphate for the Assessment of Vitamin B6 Status. Chem. Commun. 2019. 56, 317-320

293. Velema, W.A. and Kool, E.T.,* The chemistry and applications of RNA 2′-OH acylation. Nat. Rev. Chem., 2019, 4, 22-37

292. McPherson, L. A.; Troccoli, C. I.; Ji, D.; Bowles, A. E.; Gardiner, M. L.; Mohsen, M. G.; Nagathihalli, N. S.; Nguyen, D. M.; Robbins, D. J.; Merchant, N. B.; Kool, E. T.; Rai,* P.; Ford,* J. M. Increased MTH1-Specific 8-OxodGTPase Activity Is a Hallmark of Cancer in Colon, Lung and Pancreatic Tissue. DNA Repair.2019, 83, 102644.

291. Tahara, Y., Kietrys, A.M., Hebenbrock, M., Lee, Y., Wilson, D.L., and Kool, E.T.,* Dual Inhibitors of 8-Oxoguanine Surveillance by OGG1 and NUDT1, ACS Chem. Biol., 2019, Just accepted manuscript

290. Mohsen, M.G., Ji, D.,and Kool, E.T.,* Polymerase synthesis of four-base DNA from two stable dimeric nucleotides, Nucleic Acids Res., 2019, 47, 18, 9495–9501

289. Habibian, M., Velema, W.A., Kietrys, A.M., Onishi, Y., Kool, E.T.,* Polyacetate and Polycarbonate RNA: Acylating Reagents and Properties, Org. Lett., 2019,21, 14, 5413-5416 

288. Park, H.S., Kietrys, A.M., and Kool, E.T.,* Simple Alkanoyl Acylating Agents for Reversible RNA Functionalization and Control, Chem. Comm.,
2019,55, 5135-5138 

287. Nagel, Z.D., Beharry, A.A., Mazzucato, P., Kitange, G.J., Sarkaria, J.N., Kool, E.T., and Samson, L.D., * Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cellsPLoS ONE2019

286. Mohsen, M.G., Ji, D.,and Kool, E.T.,* Polymerase-Amplified Release of ATP (POLARA) for Detecting Single Nucleotide Variants in RNA and DNAChem. Sci.2019, 10, 3264-3270

285. Velema, W.A. and Kool, E.T.,* Water-Soluble Leaving Group Enables Hydrophobic Functionalization of RNAOrg. Lett.201820, 6587–6590

284. Wilson, D.L., Beharry, A.A., Srivastava, A., O’Connor, T.R., and Kool, E.T.,* Fluorescence Probes of ALKBH2 Measure DNA Alkylation Repair and Drug Resistance ResponsesAngew. Chem. Int. Ed. Engl.2018, 57, 12896-12900

283. Larsen, D., Kietrys, A.M., Clark, S.A., Park, H.S., Ekebergh, A., and Kool, E.T.,* Exceptionally rapid oxime and hydrazone formation promoted by catalytic amine buffers with low toxicityChem. Sci.20189, 5252-5259

282. Ji, D., Kietrys, A.M., Lee, Y., and Kool, E.T.,* ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine TriphosphataseBioconjugate Chem.201829, 1614-1621

281. Velema, W.A., Kietrys, A.M., and Kool, E.T.,* RNA Control by Photoreversible AcylationJ. Am. Chem. Soc.2018140, 3491-3495

280. Tahara, Y., Auld, D., Ji, D., Beharry, A.A., Kietrys, A.M., Wilson, D.L., Jimenez, M., King, D., Nguyen, Z., and Kool, E.T.,* Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase (OGG1)J. Am. Chem. Soc.2018140, 2105-2114

279. Kadina, A., Kietrys, A.M., and Kool, E.T.,* RNA Cloaking by Reversible AcylationAngew. Chem. Int. Ed. Engl.201857, 3059-3063

278. Wilson, D.L. and Kool, E.T.,* Fluorescent Probes of DNA RepairACS Chem. Biol.201713, 1721–1733

277. Kietrys, A.M., Velema, W.A., and Kool, E.T.,* Fingerprints of Modified RNA Bases from Deep Sequencing ProfilesJ. Am. Chem. Soc.2017139, 17074–17081

276. Xu, W., Chan, K.M., and Kool, E.T.,* Fluorescent nucleobases as tools for studying DNA and RNANat. Chem.20179, 1043–1055

275. Ji, D., Stepchenkova, E.I., Cui, J., Menezes, M.R., Pavlov, Y.I.,* and Kool , E.T.,* Measuring deaminated nucleotide surveillance enzyme ITPA activity with an ATP-releasing nucleotide chimeraNucleic Acids Res2017, 45, 11515–11524

274. Chan, K.M., Xu, W., Kwon, H., Kietrys, A.M., Kool, E.T.,* Luminescent Carbon Dot Mimics Assembled on DNAJ. Am. Chem. Soc.2017139, 13147–13155.

273. Kölmel, D.K., Kool, E.T.,* Oximes and Hydrazones in Bioconjugation: Mechanism and CatalysisChem. Rev.2017117, 10358–10376.

272. Chan, K.M., Kölmel, D.K., Wang, S., Kool, E.T.,* Color-Change Photoswitching of an Alkynylpyrene Excimer DyeAngew. Chem. Int. Ed. Engl.201756, 6497-6501.

271. Velema, W.A. and Kool, E.T.,* Fluorogenic Templated Reaction Cascades for RNA DetectionJ. Am. Chem. Soc.2017139, 5405-5411.

270. Kwon, H., Chan, K.M., Kool, E.T.,* DNA as an environmental sensor: detection and identification of pesticide contaminants in water with fluorescent nucleobasesOrg. Biomol. Chem.201715, 1801-1809.

269. Harcourt, E.M., Kietrys, A.M., Kool, E.T.,* Chemical and structural effects of base modifications in messenger RNANature2017541, 339–346.

268. Lee, B., Flynn, R.A., Kadina, A., Guo, J.K., Kool, E.T.,* Chang, H.Y.,* Comparison of SHAPE reagents for mapping RNA structures inside living cellsRNA201723, 169-174.

267. Clark, S.A., Singh, V., Mendoza, D.V., Margolin, W., Kool, E.T.,* Light-Up “Channel Dyes” for Haloalkane-Based Protein Labeling in Vitro and in Bacterial CellsBioconjugate Chem., 201627, 2839-2843.

266. Mohsen, M.G., Kool, E.T.,* The Discovery of Rolling Circle Amplification and Rolling Circle TranscriptionAccts. Chem. Res.2016,49, 2540-2550.

265. Kent, T., Rusanov, T.D., Hoang, T.M., Velema, W.A., Krueger, A.T., Copeland, W.C., Kool, E.T., Pomerantz, R.T.,* DNA polymerase θ specializes in incorporating synthetic expanded-size (xDNA) nucleotidesNucleic Acids Res., 201644, 9381-9392.

264. Ji, D., Beharry, A.A., Ford, J.M., Kool, E.T.,* A Chimeric ATP-Linked Nucleotide Enables Luminescence Signaling of Damage Surveillance by MTH1, a Cancer Target,J. Am. Chem. Soc., 2016138, 9005-9008.

263. Yuen, L.H., Saxena, N.S., Park, H.S., Weinberg, K., Kool, E.T.,* Dark Hydrazone Fluorescence Labeling Agents Enable Imaging of Cellular Aldehydic Load,ACS Chem. Biol., 201611, 2312-2319.

262. Kölmel, D.K., Barandun, L.J., Kool, E.T.,* Efficient synthesis of fluorescent alkynyl C-nucleosides via Sonogashira coupling for the preparation of DNA-based polyfluorophores,Organ. Biomol. Chem., 201614, 6407-6412.

261. Hwang, C.S., Xu L., Wang W., Ulrich, S., Zhang, L., Chong, J., Shin, J.H., Huang, X., Kool, E.T., McKenna, C.E.,* Wang, D.,*Functional interplay between NTP leaving group and base pair recognition during RNA polymerase II nucleotide incorporation revealed by methylene substitution, Nucleic Acids Res.,2016, 44, 3820-3828.

260. Keriann Oertell, Emily M. Harcourt, Michael G. Mohsen, John Petruska, Eric T. Kool, Myron F. Goodman, Kinetic selection vs. free energy of DNA base pairing in control of polymerase fidelity, Proc. Natl. Acad. Sci. USA, 2016, 113, E2277–E2285.

259. Andrew A. Beharry, Zachary D. Nagel, Leona d. Samson, and Eric T. Kool,*Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response, PLoS One, 2016.

258. Andrew A. Beharry, Sandrine Lacoste, Timothy R. O’Connor, and Eric T. Kool,* Fluorescence Monitoring of the Oxidative Repair of DNA Alkylation Damage by ALKBH3, a Prostate Cancer Marker, J. Am. Chem. Soc., 2016, 138,3647–3650.

257. Anna M. Kietrys and Eric T. Kool,* Epigenetics: A new methyl mark on messengers, Nature, 2016, 530, 423-424.

256. Debin Ji, Michael G. Mohsen, Emily M. Harcourt, and Eric T. Kool,* ATP-Releasing Nucleotides: Linking DNA Synthesis to Luciferase Signaling, Angew. Chem. Int. Ed. Engl., 2016, 55, 2087–2091.