G&Dcover     G&D cover 2012
Journal covers highlighting work from our laboratory.

Lipsick J. A History of Cancer Research: Tumor Viruses. 2021. Cold Spring Harb Perspect Biol. Jun 1;13(6).

Lipsick J. A History of Cancer Research: Carcinogens and Mutagens. 2021. Cold Spring Harb Perspect Med. Mar 1;11(3).

Vorster PJ, Goestch P, Wijeratne TU, Guiley KZ, Andrejka L, Tripathi S, Larson B, Rubin SM, Strome S, Lipsick JL. 2020.  A long lost key opens an ancient lock: Drosophila Myb causes a synthetic multivulval phenotype in nematodes. Biology Open

Lipsick J. A History of Cancer Research: Tumor Suppressor Genes. 2020. Cold Spring Harb Perspect Biol. Feb 3;12(2).

Lipsick J. A History of Cancer Research: Tyrosine Kinases. 2019. Cold Spring Harb Perspect Biol. Feb 1;11(2).

Guiley KZ,  Iness A, Saini S, Tripathi S, Lipsick JS, Litovchick L, Rubin SM. 2018. Structural mechanism of Myb-MuvB assembly. Proc Natl Acad Sci U S A. 115: 10016-10021. [link]

Cheng MH, Andrejka L, Vorster PJ, Hinman A, Lipsick JS. 2017. The Drosophila LIN54 homolog Mip120 controls two aspects of oogenesis. Biol Open . [link]

Grigorian M, DeBruhl H, Lipsick JS. 2017. The role of variant histone H2AV in D. melanogaster larval hematopoiesis. Development 144:1441-1449. [link]

Barasch N, Gong X, Kwei KA, Varma S, Biscocho J, Qu K, Xiao N, Lipsick JS, Pelham RJ, West RB, Pollack JR. 2017. Recurrent rearrangements of the Myb/SANT-like DNA-binding domain containing 3 gene (MSANTD3) in salivary gland acinic cell carcinoma. PLoS One. 2017 Feb 17;12(2):e0171265. [link]

Debruhl H, Wen H, Lipsick JS. 2013. The Drosophila Myb and RB/E2F2 complex regulates cytokinesis in a histone H2Av-dependent manner. Molec Cell Biology 33:1809-18. [link]

Davidson CJ, Guthrie EE, Lipsick JS. 2013. Duplication and maintenance of the Myb genes of vertebrate animals. Biology Open 2:101-10. [link]

Sim CK, Perry S, Tharadra SK, Lipsick JS, Ray A. 2012. Epigenetic regulation of olfactory gene expression by the Myb-MuvB/dREAM complex. Genes & Development 26: 2483-98. [link]

Lewis PW, Sahoo D, Geng C, Bell M, Lipsick JS, Botchan MR. 2012. Drosophila Lin-52 Acts in Opposition to Repressive Components of the Myb-MuvB/dREAM Complex. Molec Cell Biology 32: 3218-27. [link]

Andrejka L, Wen H, Ashton J, Grant M, Iori K, Wang A, Manak JR, Lipsick JS. 2011. Animal-specific C-terminal domain links myeloblastosis oncoprotein (Myb) to an ancient repressor complex. Proc Natl Acad Sci U S A  108:17438-43. [link]

West RB, Kong C, Clarke N, Gilks T, Lipsick JS, Cao H, Kwok S, Montgomerty KM, Varma S, Le QT. 2011. MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol 35: 92-9. [link]

Lipsick JS. 2010. The C-MYB story — is it definitive? Proc Natl Acad Sci U S A. 107: 17067-8. [link]

Wen H, Andrejka L, Ashton J, Karess R, and Lipsick JS. 2008. Epigenetic regulation of gene expression by Drosophila Myb and E2F2-RBF via the Myb-MuvB/dREAM complex. Genes & Development 22: 601-14. [link]

Ko ER, Ko D, Chen C, Lipsick JS. 2008. A conserved acidic patch in the Myb domain is required for activation of an endogenous target gene and for chromatin binding. Molecular Cancer 7: 77.  [link]

Manak JR, Wen H, Van T, Andrejka L, Lipsick JS. 2007. Loss of Drosophila Myb interrupts the progression of chromosome condensation. Nature Cell Biology 9: 581-7. [link]

Wang DM, Sevcikova S, Wen H, Roberts S, Lipsick JS. 2007. v-Myb represses the transcription of Ets-2. Oncogene 26: 1238-44. [link]

Navratilova J, Horvath V, Kozubik A, Lojek A, Lipsick J, Smarda J. 2007. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. Differentiation 75: 592-604. [link]

Fu S, Ganter B, Lipsick JS. 2006.  Myb proteins inhibit fibroblast transformation by v-Rel. Molecular Cancer 5: 54. [link]

Davidson CJ, Tirouvanziam R, Herzenberg LA, Lipsick JS. 2005. Functional evolution of the vertebrate Myb gene family: B-Myb, but neither A-Myb nor c-Myb, complements Drosophila Myb in hemocytes. Genetics 169: 215-29. [link].

Lipsick, JS. 2004. synMuv Verite– Myb Comes Into Focus. Genes & Development 18: 2837-44. [link]

Tirouvanziam R, Davidson CJ, Lipsick JS, Herzenberg LA. 2004. Fluorescence-activated cell sorting (FACS) of Drosophila hemocytes reveals important functional similarities to mammalian leukocytes.  Proc Natl Acad Sci U S A 101: 2912-7. [link]

Beall, EL, Manak, JR, Zhou, S, Bell M, Lipsick JS, Botchan MR.  2002. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature 420: 833-7. [link]

Manak JR, Mitiku N, Lipsick JS.  2002.  Mutation of the Drosophila homologue of the Myb proto-oncogene causes genomic instability. Proc. Natl. Acad. Sci. USA 99: 7438-43. [link]

Wang DM, Lipsick JS. 2002. Mutational analysis of the transcriptional activation domains of v-Myb. Oncogene 21: 1611-5. [link]

Ladendorff NE , Wu S, Lipsick, JS. 2001. BS69, an adenovirus E1A-associated protein binds to and inhibits the transcriptional activity of c-Myb. Oncogene, 20:125-32. [link]

Wang DM, Dubendorff JW, Woo CH, Lipsick JS.  1999. Functional analysis of carboxy-terminal deletion mutants of c-Myb. J. Virol. 73: 5875-86. [link]

Lipsick JS, Wang DM. 1999. Transformation by v-Myb. Oncogene 18: 3047-55. [link]

Dubendorff, JW, Lipsick JS. 1999. Transcriptional regulation by the carboxyl-terminus of c-Myb depends upon both the Myb DNA-binding domain and the DNA recognition site. Oncogene 18: 3452-60. [link]

Ganter B, Lipsick JS. 1999. Myb and oncogenesis. Adv. Cancer Res. 76: 21-60. [link]

Ganter B, Chao ST , Lipsick JS. 1999. Transcriptional activation by the myb proteins requires a specific local promoter structure FEBS Lett. 460:401-10. [link]

Woo CH, Sopchak L, Lipsick JS. 1988. Overexpression of an alternatively spliced form of c-Myb results in increased transactivation and transforms avian myelomonoblasts. J. Virol. 72: 6813-21. [link]

Ohi R, Feoktistova A, McCann S, Valentine V, Look T, Lipsick JS, Gould KL. 1998. Myb-related Schizosaccharomyces pombe cdc5p is structurally and functionally conserved in eukaryotes. Mol. Cell. Biol. 18: 4097-108. [link]

Ganter B, Fu SL, Lipsick JS. 1998. D-type cyclins repress transcriptional activation by the v-Myb but not the c-Myb DNA-binding domain. EMBO Journal 17: 255-68. [link]

Ganter B, Lipsick JS. 1997. Myb binding sites within the N-ras promoter repress transcription. Oncogene 15:193-202. [link]

Engelke U, Wang DM, Lipsick JS. 1997. Cells transformed by a v-Myb-estrogen receptor fusion differentiate into multinucleated giant cells. J. Virol. 71:3760-6. [link]

Fu SL, Lipsick JS. 1997. Constitutive expression of full-length c-Myb transforms avian cells characteristic of both the monocytic and granulocytic lineages. Cell Growth Diff. 8:35-45. [link]

Zheng Z, Brockel C, Ganter B, Lipsick J, Sasaki M, Ogata K, Nishimura Y, Jardetzky O. 1996. Amide proton exchange rates in c-Myb DNA-binding domain. Quart. Magn. Res. in Biol. Med. 3:33-45.

Lipsick JS. 1996. One billion years of Myb. Oncogene 13:223-35. [link]

Fu SL, Lipsick JS. 1996. FAETL motif required for leukemic transformation by v-Myb. J. Virol. 70:5600-10. [link]

Chen R, Fields S, Lipsick JS. 1995. Dissociation of transcriptional activation and oncogenic transformation by v-Myb. Oncogene 11:1771-9. [link]

Dini PW, Eltman JT, Lipsick JS. 1995. Mutations in the DNA-binding and transcriptional activation domains of v-Myb cooperate in transformation. J. Virol. 69:2515-24. [link]

Engelke U, Smarda J, Lipsick JS. 1995. By-pass of TPA-induced differentiation and cell cycle arrest by the c-Myb DNA-binding domain. Oncogene 11:735-41. [link]

Engelke U, Whittaker L, Lipsick JS. 1995. Weak transcriptional activation is sufficient for transformation by v-Myb. Virology 208:467-77. [link]

Smarda J, Sugarman J, Glass C, Lipsick JS. 1995. Retinoic acid receptor-a suppresses transformation by v-myb. Mol. Cell. Biol. 15:2474-81. [link]

Engelke U, Lipsick JS. 1994. Transformation of myelomonocytic cells by the avian myeloblastosis virus is determined by the v-myb oncogene, not by the unique long terminal repeats of the virus. J. Virol. 68:2752-55. [link]

Smarda J, Lipsick JS. 1994. c-Myb prevents TPA-induced differentiation and cell death in v-Myb transformed monoblasts. Oncogene 9:237-45. [link]

Aziz, N., J. Wu, J. W. Dubendorff, J. S. Lipsick, T. W. Sturgill, and T. P. Bender. 1993. c-Myb and v-Myb are differentially phosphorylated by p42mapk in vitro. Oncogene 8:2259-65. [link]

Bin, X. and J. S. Lipsick. 1993. Individual repeats of Drosophila Myb can function in transformation by v-Myb. J. Virol. 67:7332-9. [link]

Chen, R. H. and J. S. Lipsick. 1993. Differential transcriptional activation by v-myb and c-myb in animal cells and Saccharomyces cerevisiae. Mol. Cell. Biol. 13:4423-31. [link]

Dini, P. W. and J. S. Lipsick. 1993. Oncogenic truncation of the first repeat of c-Myb decreases DNA-binding in vitro and in vivo. Mol. Cell. Biol. 13:7334-48. [link]

Smarda, J. and J. S. Lipsick. 1993. Dicistronic selection for nuclear proteins in living animal cells. Gene 137:145-9. [link]

Dubendorff, J. W., L. Whittaker, J. Eltman, and J. S. Lipsick. 1992. Carboxy-terminal elements of C-Myb negatively regulate transcriptional activation in cis and in trans. Genes Dev. 6:2524-35. [link]

Garrido, C., D. Leprince, J. S. Lipsick, D. Stehelin, D. Gospodarowicz, and S. Saule. 1992. Definition of functional domains in P135gag-myb-ets and p48v-myb proteins required to maintain the response of neuroretina cells to basic fibroblast growth factor. J. Virol. 66:160-6. [link]

Garrido, C., F. Grasser, J. S. Lipsick, D. Stehelin, and S. Saule. 1992. Protein truncation is not required for c-myb proto-oncogene activity in neuroretina cells. J. Virol. 66:6773-6. [link]

Grasser, F. A., K. LaMontagne, L. Whittaker, S. Stohr, and J. S. Lipsick. 1992. A highly conserved cysteine in the v-Myb DNA-binding domain is essential for transformation and transcriptional trans-activation. Oncogene 7:1005-9. [link]

Siu, G., A. L. Wurster, J. S. Lipsick, and S. M. Hedrick. 1992. Expression of the CD4 gene requires a Myb transcription factor. Mol. Cell. Biol. 12:1592-604. [link]

Stober-Grasser, U., B. Brydolf, X. Bin, F. A. Grasser, R. A. Firtel, and J. S. Lipsick. 1992. The Myb DNA-binding domain is highly conserved in Dictyostelium discoideum. Oncogene 7:589-96. [link]

Garcia, A., K. LaMontagne, D. Reavis, U. Stober-Grasser, and J. S. Lipsick. 1991. Determinants of sequence-specific DNA-binding by p48v-myb. Oncogene 6:265-73. [link]

Grasser, F. A., T. Graf, and J. S. Lipsick. 1991. Protein truncation is required for the activation of the c-myb proto-oncogene. Mol. Cell. Biol. 11:3987-96. [link]

Ibanez, C. E. and J. S. Lipsick. 1990. trans activation of gene expression by v-myb. Mol. Cell. Biol. 10:2285-93. [link]

Lane, T. N., C. E. Ibanez, A. Garcia, T. Graf, and J. S. Lipsick. 1990. Transformation by v-myb correlates with transactivation of gene expression. Mol. Cell. Biol. 10:2591-8. [link]

Ibanez, C. E., A. Garcia, U. Stober-Grasser, and J. S. Lipsick. 1988. DNA-binding activity associated with the v-myb oncogene product is not sufficient for transformation. J. Virol. 62:4398-402. [link]

Ibanez, C. E. and J. S. Lipsick. 1988. Structural and functional domains of the myb oncogene: Requirements for nuclear transport, myeloid transformation, and colony formation. J. Virol. 62:1981-8. [link]

Stober-Grasser, U. and J. S. Lipsick. 1988. Specific amino acid substitutions are not required for transformation by v-myb of avian myeloblastosis virus. J. Virol. 62:1093-6. [link]

Lipsick, J. S. and C. E. Ibanez. 1987. env-encoded residues are not required for transformation by p48v-myb. J. Virol. 61:933-6. [link]

Lipsick, J. S. 1987. v-myb does not prevent the expression of c-myb in avian erythroblasts. J. Virol. 61:3284-7. [link]

Lipsick, J. S. and W. J. Boyle. 1987. c-myb protein expression is a late event during T-lymphocyte activation. Mol. Cell. Biol. 7:3358-60. [link]

Boyle, W. J., J. S. Lipsick, and M. A. Baluda. 1986. Antibodies to the evolutionarily conserved aminoterminal region of the v-myb-encoded protein detect the c-myb protein in widely divergent metazoan species. Proc. Nat. Acad. Sci. USA 83:4685-9. [link]

Lipsick, J. S., C. E. Ibanez, and M. A. Baluda. 1986. Expression of molecular clones of v-myb in avian and mammalian cells independently of transformation. J. Virol. 59:267-75. [link]

Perbal, B., J. S. Lipsick, J. Svoboda, R. F. Silva, and M. A. Baluda. 1985. Biologically active proviral clone of myeloblastosis-associated virus type 1: Implications for the genesis of avian myeloblastosis virus. J. Virol. 56:240-4. [link]

Boyle, W. J., M. A. Lampert, J. S. Lipsick, and M. A. Baluda. 1984. Avian myeloblastosis virus and E26 virus oncogene products are nuclear proteins. Proc. Nat. Acad. Sci. USA 81:4265-9. [link]

Boyle, W. J., J. S. Lipsick, E. P. Reddy, and M. A. Baluda. 1983. Identification of the leukemogenic protein of avian myeloblastosis virus and of its normal cellular homologue. Proc. Nat. Acad. Sci. USA 80:2834-28. [link]

Lipsick, J. 1974. On the Wire (poem). Atlantic Monthly 234:61.