Publications

Mudgett laboratory publications:

Fast Wide-field Light Sheet Electro-optic FLIM. Knight, V.R., Bode, N., Dowlatshahi, D. P., Kim, J. G., Mudgett, M. B., Wakatsuki, S., Bowman, A. J., Kasevixh, M. A. (2025) arXiv. 2501.15012v1 [physics.optics] doi: 10.48550/arXiv.2501.15012

Transcriptome analysis reveals role for WRKY70 in early N-hydroxy-pipecolic acid signaling. Foret, J., Kim, J. G., Sattely, E. S., Mudgett, M. B. (2024) Plant Physiol. 197, kiae544 doi: 10.1093/plphys/kiae544

Multiple acquisitions of XopJ2 effectors in populations of Xanthomonas perforans. Sharma, A., Iruegas-Bocardo, F., Bibi, S., Chen, Y. C., Kim, J. G., Abrahamian, P., Minsavage, G. V., Hurlbert, J. C., Vallad, G. E., Mudgett, M. B., Jones, J. B., Goss, E. M. (2024) MPMI. doi: 10.1094/MPMI-05-24-0048-R

Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition. Sheikh, A.H., Zacharia, J., Parda, A. B., Dominguez-Ferreras, A., Sueldo, D. J., Kim, J.-G., Balmuth, A., Gutierrez, J. R., Conlan, B. F., Ullah, N., Nippe, O. M., Girija, A. M., Sessa, G., Jones, A. M. E., Mudgett, M. B., Rathjen, J. P. and Ntoukakis V. (2023) Nature Commun. doi: 10.1038/s41467-023-38103-6

Deconvoluting signals downstream of growth and immune receptor kinases by phosphocodes of the BSU1 family phosphatases. Park, C. H., Bi, Y., Youn, J., Kim, S., Kim, J., Xu, N. Y., Shrestha, R., Burlingame, A. L., Xu, S., Mudgett, M. B., Kim, S., Kim, T., Wang, Z. (2022) Nature plants doi: 10.1038/s41477-022-01167-1

A bacterial effector counteracts host autophagy by promoting degradation of an autophagy component. Leong, J. X., Raffeiner, M., Spinti, D., Langin, G., Franz-Wachtel, M., Guzman, A. R., Kim, J.-G., Pandey, P., Minina, A. E., Macek, B., Hafrén, A., Bozkurt, T. O., Mudgett, M. B., Börnke, F., Hofius, D., and Üstün, S. (2022) Embo J. doi: 10.15252/embj.2021110352

BSU1 family phosphatases mediate flagellin-FLS2 signaling through specific phosphocodes. Park, C. H., Youn, J.-H., Xu, S., Kim, J.-G., Yang, B., Xu, N., Mudgett, M. B., Kim, S.-K., Kim, T.-W., and Wang, Z.-Y. (2022) Nature Plant doi: 10.1038/s41477-022-01167-1.

Arabidopsis bZIP11 is a susceptibility factor during Pseudomonas syringae infection. Prior, M. J., Selvanayagam, J., Kim, J., Tomar, M., Jonikas, M., Mudgett, M. B., Smeekens, S., Hanson, J., Frommer, W. B. (2021) MPMI doi: 10.1094/MPMI-11-20-0310-R

Arabidopsis UGT76B1 glycoslyates N-hydroxy-pipecolic acid and inactivates systemic acquired resistance in tomato. Holmes, E. C., Chen, Y.-C., Mudgett, M. B., and Sattely, E. (2021) Plant Cell doi:10.1093/plcell/koaa052

Tomato atypical receptor kinase1 is involved in the regulation of pre-invasion defense. Guzman, A., Kim, J.-G., Taylor, K., and Mudgett, M. B. (2020) Plant Physiol. 183: 1306-1318. doi: https://doi.org/10.1104/pp.19.01400

BSU1 family phosphatases mediate flagellin-FLS2 signaling through a specific phosphocode. Park, C. H., Youn, J.-H., Xu, S., Kim, J.-G., Yang, B., Xu, N., Mudgett, M. B., Kim, S.-K., Kim, T.-W., and Wang, Z.-Y. (2019) bioRxiv. doi: https://doi.org/10.1101/685610.

A pathogen-responsive gene cluster for the production of highly modified fatty acids in tomato. Jeon, J. E., Kim, J.-G., Fischer, C. R., Mehta, Niraj, Dufour-Schroif, C., Wemmer, K., Mudgett, M. B. and Sattely, E. (2020) Cell 180: 176-87.e19.

Tomato bHLH132 transcription factor controls growth and defense and is activated by the Xanthomonas euvesicatoria effector XopD during pathogenesis. Kim, J.-G. and Mudgett, M. B. (2019) Mol. Plant-Microbe Inter. 32: 1614-1622. doi: https://doi.org/10.1094/MPMI-0519-0122-R.

An engineered pathway for N-hydroxy-pipecolic acid synthesis enhances systemic acquired resistance in tomato. Holmes, E. C., Chen, Y.-C., Sattely, E., and Mudgett, M. B. (2019) Science Signaling 12: 604, eaay3066, doi: 10.1126/scisignal.aay3066.

Conservation of N-hydroxy-pipecolic acid-mediated systemic acquired resistance in crop plants. Holmes, E.C., Chen, Y.-C., Sattely, E., and Mudgett, M. B. (2019) bioRxiv. doi: https://doi.org/10.1101/537597.

Aphid effector Me10 interacts with tomato TFT7, a 14-3-3 isoform involved in aphid resistance. Chaudhary, R., Peng, H.-C., He, J., MacWilliams, J., Teixeira, M. , Tsuchiya, T., Chesnais, Q., Mudgett, M.B. and Kaloshian, I. (2018) New Phytol. doi/10.1111/nph.15475.

N-hydroxy-pipecolic acid is a mobile metabolite that induces systemic disease resistance in Arabidopsis. Chen, Y.-C., Holmes, E.C., Rajniak, J., Kim, J.-G., Tang, S. Fischer, C.R., Mudgett, M. B. and Sattely, E. (2018) Proc. Nat. Acad. Sci. USA 115: E4920-E4029. Doi: https://doi.org/10.1073/pnas.1805291115

Tomato 14-3-3 proteins are required for Xv3 disease resistance and interact with a subset of Xanthomonas euvesicatoria effectors. Dubrow, Z., Sunitha, S., Kim, J.-G., Aakre, C.D., Girija, A.M., Sobol, G., Teper, D., Chen, Y.-C., Ozbaki-Yagan, N.,Vance, H., Sessa, G., and Mudgett, M.B. (2018) Mol. Plant-Microbe Inter.: doi/10.1094.

Quantification of Ethylene Production in tomato leaves infected by Xanthomonas euvesicatoria. Kim, J.-G., Stork, W., and Mudgett, M. B. (2016) Bio-protocol 6(3): e1723. DOI: 10.21769/BioProtoc. 723; www.bio-protocol.org/e1723 .

Functional Analysis of Plant Defense Suppression and Activation by the Xanthomonas Core Type III Effector XopX. Stork, W., J. G. Kim, and M. B. Mudgett (2015). Mol Plant Microbe Interact 28(2): 180-194.

A comprehensive analysis of microProteins reveals their potentially widespread mechanism of transcriptional regulation. Magnani, E., N. de Klein, H. I. Nam, J. G. Kim, K. Pham, E. Fiume, M. B. Mudgett and S. Y. Rhee (2014). Plant Physiol 165(1): 149-159.

The bHLH transcription factor HBI1 mediates the trade-off between growth and pathogen-associated molecular pattern-triggered immunity in Arabidopsis. Fan, M., M. Y. Bai, J. G. Kim, T. Wang, E. Oh, L. Chen, C. H. Park, S. H. Son, S. K. Kim, M. B. Mudgett and Z. Y. Wang (2014). Plant Cell 26(2): 828-841.

AvrBsT acetylates Arabidopsis ACIP1, a protein that associates with microtubules and is required for immunity. Cheong, M. S., A. Kirik, J. G. Kim, K. Frame, V. Kirik and M. B. Mudgett (2014). PLoS Pathog 10(2): e1003952.

A robust methodology to subclassify pseudokinases based on their nucleotide-binding properties. Murphy, J. M., Q. Zhang, S. N. Young, M. L. Reese, F. P. Bailey, P. A. Eyers, D. Ungureanu, H. Hammaren, O. Silvennoinen, L. N. Varghese, K. Chen, A. Tripaydonis, N. Jura, K. Fukuda, J. Qin, Z. Nimchuk, M. B. Mudgett, S. Elowe, C. L. Gee, L. Liu, R. J. Daly, G. Manning, J. J. Babon and I. S. Lucet (2014). Biochem J 457(2): 323-334.

Xanthomonas euvesicatoria type III effector XopQ interacts with tomato and pepper 14-3-3 isoforms to suppress effector-triggered immunity. Teper, D., D. Salomon, S. Sunitha, J. G. Kim, M. B. Mudgett and G. Sessa (2014). Plant J 77(2): 297-309.

Xanthomonas type III effector XopD desumoylates tomato transcription factor SlERF4 to suppress ethylene responses and promote pathogen growth. Kim, J. G., W. Stork and M. B. Mudgett (2013). Cell Host Microbe 13(2): 143-154.

Regulation of cell wall-bound invertase in pepper leaves by Xanthomonas campestris pv. vesicatoria type three effectors. Sonnewald, S., J. P. Priller, J. Schuster, E. Glickmann, M. R. Hajirezaei, S. Siebig, M. B. Mudgett and U. Sonnewald (2012). PLoS One 7(12): e51763.

Tomato TFT1 is required for PAMP-triggered immunity and mutations that prevent T3S effector XopN from binding to TFT1 attenuate Xanthomonas virulence. Taylor, K. W., J. G. Kim, X. B. Su, C. D. Aakre, J. A. Roden, C. M. Adams and M. B. Mudgett (2012). PLoS Pathog 8(6): e1002768.

Comparative analysis of the XopD type III secretion (T3S) effector family in plant pathogenic bacteria. Kim, J. G., K. W. Taylor and M. B. Mudgett (2011). Mol Plant Pathol 12(8): 715-730.

Sugar transporters for intercellular exchange and nutrition of pathogens. Chen, L. Q., B. H. Hou, S. Lalonde, H. Takanaga, M. L. Hartung, X. Q. Qu, W. J. Guo, J. G. Kim, W. Underwood, B. Chaudhuri, D. Chermak, G. Antony, F. F. White, S. C. Somerville, M. B. Mudgett and W. B. Frommer (2010). Nature 468(7323): 527-532.

SOBER1 phospholipase activity suppresses phosphatidic acid accumulation and plant immunity in response to bacterial effector AvrBsT. Kirik, A. and M. B. Mudgett (2009). Proc Natl Acad Sci U S A 106(48): 20532-20537.

Xanthomonas T3S Effector XopN Suppresses PAMP-Triggered Immunity and Interacts with a Tomato Atypical Receptor-Like Kinase and TFT1. Kim, J. G., X. Li, J. A. Roden, K. W. Taylor, C. D. Aakre, B. Su, S. Lalonde, A. Kirik, Y. Chen, G. Baranage, H. McLane, G. B. Martin and M. B. Mudgett (2009). Plant Cell 21(4): 1305-1323.

XopD SUMO protease affects host transcription, promotes pathogen growth, and delays symptom development in Xanthomonas-infected tomato leaves. Kim, J. G., K. W. Taylor, A. Hotson, M. Keegan, E. A. Schmelz and M. B. Mudgett (2008). Plant Cell 20(7): 1915-1929.

Blue-light-activated Histidine kinases: two-component sensors in bacteria. Swartz, T. E., Tseung, T.-S., Frederickson, M., Paris, G., Comerci, D. J., Rajashekara, G., Kim, J.-G., Mudgett, M. B., Splitter, G., Ugalde, R. A., Goldbaum, F. A., Briggs, W. R., and Bogomolni, R. A. (2007) Science 317, 1090-1093.

An alpha-amylase (At4g25000) in Arabidopsis leaves is secreted and induced by biotic and abiotic stress. Doyle, E. A., Lane, A. M., Sides, J. M., Mudgett, M. B., and Monroe, J. D. (2007) Plant Cell Environ. 30, 388-398.

The conserved Arabidopsis carboxylesterase SUPPRESSOR OF AVRBST-ELICITED RESISTANCE inhibits defenses triggered by the AvrBsT Type III Effector. Cunnac, S., Wilson, A., Nuwer, J., Kirik, A., Barnage, G., and Mudgett, M. B. (2007) Plant Cell 19, 688-705.

New insights to the function of phytopathogenic bacterial type III effectors in plants. Mudgett, M. B. (2005) Ann. Rev. Plant Biol. 56, 509-531.

A genetic screen to isolate type III effectors translocated into pepper cells during Xanthomonas infection. Roden, J. A., Belt, B., Ross, J.B., Tachibana, T., Vargas, J., and Mudgett, M. B. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 16624-16629.

Cysteine proteases in phytopathogenic bacteria: identification of plant targets and activation of innate immunity. Hotson, A. and Mudgett, M. B. (2004). Curr. Opin. Plant Biol. 7, 384-390.

Characterization of the Xanthomonas type III AvrXv4 effector, a SUMO protease translocated into plant cells. Roden, J. A., Eardley, L., Hotson, A., Cao, Y., and Mudgett, M. B. (2004) Mol. Plant-Microbe Inter. 17, 633-643.

Importance of opgH_Xcv of Xanthomonas campestris pv. vesicatoria in host parasite interactions. Minsavage, J., Stall, R. E., Mudgett, M. B., and Jones, J. B. (2004) Mol. Plant-Microbe Inter. 17, 152-161.

Xanthomonas type III effector XopD targets SUMO-conjugated proteins in planta. Hotson, A., Chosed, R., Shu, H., Orth, K., and Mudgett, M. B. (2003) Mol. Microbiol. 50, 377-389.

Mudgett Post-doctoral Research Publications

Staskawicz, B. J., Mudgett, M. B., Dangl, J. L., and Galan, J. E. (2001) Common and contrasting themes of plant and animal diseases. Science 292, 2285-2289.

Axtell, M. J., McNellis, T. W., Mudgett, M. B., Hsu, C. S., and Staskawicz, B. J. (2001) Mutational analysis of the Arabidopsis RPS2 disease resistance gene and the corresponding Pseudomonas syringae avrRpt2 avirulence gene. Mol. Plant-Microbe Inter. 14,181-188.

Orth, K., Xu, Z., Mudgett, M. B., Bao, Z. Q., Palmer, L. E., Bliska, J. B., Mangel, W. F., Staskawicz, B., and Dixon, J. E. (2000) Yersinia effector YopJ is a ubiquitin-like protein protease that disrupts signaling. Science 290, 1594-1597.

Mudgett, M. B., Chesnokova, O., Dahlbeck, D., Clark, E. T., Bonas, U., and Staskawicz, B. J. (2000) Molecular signals required for type III secretion and translocation of the Xanthomonas campestris AvrBs2 protein to pepper plants. Proc. Natl. Acad. Sci. U.S.A. 97, 13324-13329.

Mudgett, M. B. and Staskawicz, B. J. (1999) Characterization of the Pseudomonas syringae pv. tomato AvrRpt2 protein: demonstration of secretion and processing during bacterial pathogenesis. Mol. Microbiol. 32, 927-941.

McNellis, T. W., Mudgett, M. B., Li, K., Aoyama, T., Horvath, D., Chua, N-H., and Staskawicz, B. J. (1998) Glucocorticoid-inducible expression of a bacterial avirulence gene in transgenic Arabidopsis induces hypersensitive cell death. Plant J. 14, 247-257.

Mudgett, M. B. and Staskawicz, B. J. (1998) Protein signaling via type III secretion pathways in phytopathogenic bacteria. Cur. Opin. Microbiol. 1, 109-115.

Mudgett Graduate Research Publications

Mudgett, M. B., Lowenson, J. D., and Clarke, S. (1997) Protein repair L-isoaspartyl methyltransferase in plants: Phylogenetic distribution and the accumulation of substrate proteins in aged barley seeds. Plant Physiol. 115, 1481-1489.

Mudgett, M. B. and Clarke, S. (1996) A distinctly regulated protein repair L-isoaspartyl methyltransferase from Arabidopsis thaliana. Plant Mol. Biol. 30, 723-737.

Shen-Miller, J., Mudgett, M. B., Schopf, J. W., Clarke, S., and Berger, R. (1995) Exceptional seed longevity and robust growth: ancient sacred lotus from China. Amer. J. Bot. 82, 1367-1380.

Mudgett, M. B. and Clarke, S. (1994) Hormonal and environmental responsiveness of a developmentally-regulated protein repair L-isoaspartyl methyltransferase in wheat. J. Biol. Chem. 269, 25605-25612.

Mudgett, M. B. and Clarke, S. (1993) Characterization of plant L-isoaspartyl methyltransferases that may be involved in seed survival: Purification, cloning, and sequence analysis of the wheat germ enzyme. Biochemistry 32, 11100-11111.