Our laboratory is focused on enabling patients and groups outside of our University medical center to potentially benefit from our research. A critical step has been to early-stage technology transfer, to catalyze rapid development while maintaining quality control to apply for FDA clearance. These are critical steps for wider patient testing at multiple centers.
Initial technology transfer for the science of FIRM mapping was funded by the NIH (SBIR). The startup, Topera Inc, obtained initial FDA clearance in 2011 for a non-commercial prototype for limited testing at some U.S. laboratories, followed in 2013 by FDA clearance (and CE mark) for the first commercial FIRM mapping system and a dedicated basket mapping catheter. Multicenter studies from independent centers were reported in 2013-14. Topera was acquired in 2014 by Abbott Laboratories inc. Multicenter randomized trials are ongoing in the U.S. and abroad.
BIODESIGN and INNOVATION
The laboratory enjoys close collaborations between a disease-focused group of clinicians, computational physicists, bioengineers and outcome specialists. We have successfully translated our innovations to patents and novel therapy that has been commercialized by startup companies. Fellows in our Lab have enrolled in the Biodesign program, in which our collaborators (such as Dr. Paul Wang) are leading teaching faculty, and have conceived and submitted applications to the U.S. patent and trademark office.
Some patents (issued and filed) from this work are listed below.
- Sanjiv Narayan, Valmik Bhargava. “United States Patent 7,123,954 Method and Apparatus for Classifying and Localizing Heart Arrhythmias”, University of California Regents, Oct 17, 2006
- Carey R. Briggs, Sanjiv M. Narayan. “United States Patent 8,165,666 System And Method For Reconstructing Cardiac Activation Information”, University of California Regents, Apr 24, 2012
- Sanjiv M. Narayan, Wouter-Jan Rappel. “United States Patent 8,521,266 Methods for the Detection And/Or Diagnosis Of Biological Rhythm Disorders”, University of California Regents, Aug 27, 2013
- Carey R. Briggs, Sanjiv M. Narayan. “United States Patent 8,594,777 System And Method For Reconstructing Cardiac Activation Information”, University of California Regents, Nov 26, 2013
- Sanjiv Narayan. “United States Patent 8,676,303 Machine and Process for Treating Heart Instability”, University of California Regents, Mar 18, 2014
- Sanjiv M. Narayan, Ruchir Sehra. “United States Patent 8,700,140 Methods, system and apparatus for the detection, diagnosis and treatment of biological rhythm disorders”, Regents of the University of California; Topera Inc., US Department of Veterans Affairs, Apr 15, 2014
- Sanjiv M. Narayan, Wouter-Jan Rappel. “United States Patent 8,838,222 B2 Method for Treating Complex Rhythm Disorders”, University of California Regents, Sep 16, 2014
- Sanjiv M. Narayan, Wouter-Jan Rappel. “United States Patent 8,838,223 B2 Method for Analyzing Complex Rhythm Disorders.”, University of California Regents, Sep 16, 2014
- Sanjiv Narayan, Ruchir Sehra. “United States Patent 8,868,169 B2 Method and System for Detection of Biological Rhythm Disorders”, Regents of the University of California; Topera Inc; US Government represented by Dept of Veterans Affairs, Oct 21, 2014
- Sanjiv Narayan, Carey Briggs. “System and Method for Diagnosing and Treating Heart Rhythm Disorders Using Shaped Ablation”, Provisional Filed US PTO 61481512 (Priority date 05/02/11)
- Sanjiv Narayan, Carey Briggs. “System and Method for Identifying Sources for Biological Rhythms”, Provisional filed PTO 61/569,132; published 2013/0150740 AI (Priority date 12/09/11)