Alternative wnt signaling is initiated by distinct receptors.

TitleAlternative wnt signaling is initiated by distinct receptors.
Publication TypeJournal Article
Year of Publication2008
Authorsvan Amerongen R, Mikels A, Nusse R
JournalSci Signal
ISSN1937-9145 (Electronic)
AbstractAn unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ligand-receptor binding likely dictates the outcome of downstream signaling events. Unfortunately, possible complexities underlying ligand-receptor interactions are often overlooked. Here, we discuss basic principles of signal transduction initiated at the cell membrane, with the Wnt pathway, which harbors a multitude of ligands and receptors, as an example.