PDFs of recent publications

These are some of our recent papers as PDFs

 Kyle M. Loh, Renee van Amerongen,  and Roel Nusse.  Generating Cellular Diversity and Spatial Form: Wnt Signaling and the Evolution of Multicellular Animals.  Developmental Cell 38, p 643,  2016 (PDF)


Wang, B., Zhao, L., Fish, M., Logan, C.Y., and Nusse, R. (2015). Self-renewing diploid Axin2(+) cells fuel homeostatic renewal of the liver. Nature 524, 180-185.


Clevers, H., Loh, K.M., and Nusse, R. (2014). Stem cell signaling. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control. Science 346, 1248012.


Lim, X., Tan, S.H., Koh, W.L., Chau, R.M., Yan, K.S., Kuo, C.J., van Amerongen, R., Klein, A.M., and Nusse, R. (2013). Interfollicular epidermal stem cells self-renew via autocrine Wnt signaling. Science 342, 1226-1230.

Habib, S., Chen, B., Tsai, F., Anastassiadis, K., Meyer, T., Betzig, E., and Nusse, R. (2013). A Localized Wnt Signal Orients Asymmetric Stem Cell Division. Science 339, 1455-1448. Supplement with methods

Bowman AN, van Amerongen R, Palmer TD, Nusse R. Lineage tracing with Axin2 reveals distinct developmental and adult populations of Wnt/β-catenin-responsive neural stem cells. Proceedings of the National Academy of Sciences. 2013 Apr 15. 

Jan TA, Chai R, Sayyid ZN, Van Amerongen R, Xia A, Wang T, et al. Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells. Development. 2013 Feb 26;140(6):1196–206. 

Blauwkamp, T.A., Nigam, S., Ardehali, R., Weissman, I.L., and Nusse, R. (2012). Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nature Communications 3, 1070.

Van Amerongen, R., Bowman, A., and Nusse, R. (2012). Developmental stage and time dictate the fate of Wnt/beta-catenin responsive stem cells in the mammary gland. Cell Stem Cell 11, 387-400.

Van Amerongen, R., Fuerer, C., Mizutani, M. & Nusse, R. Wnt5a can both activate and repress Wnt/beta-catenin signaling during mouse embryonic development. Developmental Biology 369, 101-114, (2012).

Nusse, R., and Varmus, H. (2012). Three decades of Wnts: a personal perspective on how a scientific field developed. EMBO J 31, 2670-2684.

Clevers, H., and Nusse, R. (2012). Wnt/Beta-Catenin Signaling and Disease. Cell 149, 1192-1205.

Mulligan, K.A., Fuerer, C., Ching, W., Fish, M., Willert, K., and Nusse, R. (2012). Secreted Wingless-interacting molecule (Swim) promotes long-range signaling by maintaining Wingless solubility. Proc Natl Acad Sci U S A 109, 370-377.

Ten Berge, D., Kurek, D., Blauwkamp, T., Koole, W., Maas, A., Eroglu, E., Siu, R.K., and Nusse, R. (2011). Embryonic stem cells require Wnt proteins to prevent differentiation to epiblast stem cells. Nat Cell Biol. 13, 1070-1075.

Zeng, Y.A., and Nusse, R. (2010). Wnt proteins are self-renewal factors for mammary stem cells and promote their long-term expansion in culture. Cell Stem Cell 6, 568-577.

Fuerer, C., and Nusse, R. (2010). Lentiviral vectors to probe and manipulate the wnt signaling pathway. PLoS One 5, e9370.

van Amerongen, R., and Nusse, R. (2009). Towards an integrated view of Wnt signaling in development. Development 136, 3205-3214.

Mikels, A., Minami, Y., and Nusse, R. (2009). Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J Biol Chem 284, 30167-30176.

Ten Berge, D., Koole, W., Fuerer, C., Fish, M., Eroglu, E., and Nusse, R. (2008). Wnt signaling mediates self-organization and axis formation in embryoid bodies. Cell Stem Cell 3, 508-518.

Ten Berge, D., Brugmann, S.A., Helms, J.A., and Nusse, R. (2008). Wnt and FGF signals interact to coordinate growth with cell fate specification during limb development. Development 135, 3247-3257.

Kalani, M.Y., Cheshier, S.H., Cord, B.J., Bababeygy, S.R., Vogel, H., Weissman, I.L., Palmer, T.D., and Nusse, R. (2008). Wnt-mediated self-renewal of neural stem/progenitor cells. Proc Natl Acad Sci U S A 105, 16970 –16975.

Ching, W., Hang, H.C., and Nusse, R. (2008). Lipid-independent secretion of a Drosophila Wnt protein. J Biol Chem 283, 17092-17098.


Nusse, R. (2008). Wnt signaling and stem cell control. Cell Res 18, 523-527.


Fish, M.P., Groth, A.C., Calos, M.P., and Nusse, R. (2007). Creating transgenic Drosophila by microinjecting the site-specific phiC31 integrase mRNA and a transgene-containing donor plasmid. Nat Protoc 2, 2325-2331.


Mikels, A.J., and Nusse, R. (2006). Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol 4, e115.

Gordon, M.D., Dionne, M.S., Schneider, D.S., and Nusse, R. (2005). WntD is a feedback inhibitor of Dorsal/NF-kappaB in Drosophila development and immunity. Nature 437, 746-749.

Nelson, W., and Nusse, R. (2004). Convergence of Wnt, beta-catenin and Cadherin Pathways. Science 303, 1483-1487.

Willert, K., Brown, J.D., Danenberg, E., Duncan, A.W., Weissman, I.L., Reya, T., Yates, J.R., and Nusse, R. (2003). Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448-452.