Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition.
Submitted by Anonymous on Fri, 08/12/2016 - 12:35
Title | Fibrosis of the Neonatal Mouse Heart After Cryoinjury Is Accompanied by Wnt Signaling Activation and Epicardial-to-Mesenchymal Transition. |
Publication Type | Journal Article |
Year of Publication | 2016 |
Authors | Mizutani M, Wu JC, Nusse R |
Journal | Journal of the American Heart Association |
Volume | 5 |
Issue | 3 |
Pagination | e002457 |
Date Published | 2016 Mar 15 |
Abstract | The adult mammalian heart responds to cardiac injury by formation of persistent fibrotic scar that eventually leads to heart failure. In contrast, the neonatal mammalian heart reacts to injury by the development of transient fibrotic tissue that is eventually replaced by regenerated cardiomyocytes. How fibrosis occurs in the neonatal mammalian heart remains unknown. To start elucidating the molecular underpinnings of neonatal cardiac fibrosis, we investigated Wnt signaling in the neonatal heart after cryoinjury. |
URL | http://jaha.ahajournals.org/cgi/pmidlookup?view=long&pmid=27068625 |
DOI | 10.1161/JAHA.115.002457 |
Short Title | J Am Heart Assoc |