@article {cite-key,
	title = {Structure and nucleotide sequence of the putative mammary oncogene int-1; proviral insertions leave the protein-encoding domain intact.},
	journal = {Cell},
	volume = {39},
	number = {1},
	year = {1984},
	month = {Nov},
	pages = {233{\textendash}240},
	abstract = {Many mammary tumors induced by mouse mammary tumor virus (MMTV) contain a provirus in the same region of the host-cell genome, leading to expression of a putative cellular oncogene called int-1. Here we present the structure and nucleotide sequence of int-1. We have established several proviral insertion sites exactly by nuclease S1 analysis or by molecular cloning and DNA sequencing. The protein-encoding domain of int-1 is distributed over four exons. At the 5{\textquoteright} end of the gene two overlapping exons were detected, one of which is preceded by a TATA box. The deduced int-1-encoded protein has 370 amino acids, with a preponderance of hydrophobic residues at the NH2 terminus. Proviruses are found at both sides of the gene, usually oriented away from the gene. Downstream integrations occur frequently in the long 3{\textquoteright} untranslated region of the last exon. One upstream provirus is inserted in the 5{\textquoteright} untranslated region and, unlike the other upstream insertions, in the same orientation as the int-1 gene. Proviral integrations always leave the protein-encoding domain intact, providing further evidence that the int-1 protein contributes an essential step in mammary tumorigenesis.},
	issn = {0092-8674 (Print); 0092-8674 (Linking)},
	author = {van Ooyen, A and Nusse, R}
}
