Diagnostic Tests, Management & Therapy
Trichomoniasis is usually treated with Metronidazole, an antibiotic and antiparasitic drug. Metronidazole eliminates T. vaginalis by inhibiting nucleic acid synthesis. It is classified as a nitroimidazole.
The structure of Metronidazole:
Brand names of Metronidazole include: Flagyl, Metryl, Protostat, Satric, Neo-Tric
Dosing: Metronidazole 2 grams by mouth (usually 4, 500 mg tabs) or 500 mg twice a day by mouth for 7 days. The single dose has a high success rate (90%+) and good compliance.
Resistance: Intravagical application of nonoxynol-9, a spermicide, may be somewhat effective against metronidazole-resistant strains. Mebendazole and furazolidone may also be effective. Topical metronidazole is not absorbed sufficiently well to eliminate T. vaginalis.