History of Discovery

Although T. gondii was first observed in rodents by Nicolle and Manceaux in 1908, it was not identified as an agent of infectious disease until 1932. That case occurred in a congenitally infected infant, as did another case of toxoplasma encephalitis reported in 1939 by Wolf et al. T. gondii beause recognized as a severe and potentially fatal disease of adults in 1968 after several cases of toxoplasma encephalitis were found in patients with hematologic cancers. It then became more widely recorded as a cause of morbidity in immunodeficient patients, including AIDS patients beginning in 1983. T. gondii continues to be an important disease in the modern world, especially in pregnant women and immunocompromised patients.

Mandell, Bennett, and Dolin.



Last Update: 24 May 2006