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Mild departures from the model can lead to overestimating $ K$

When there is real population structure, this leads to LD among unlinked loci and departures from Hardy-Weinberg proportions. Roughly speaking, this is the signal that is used by the structure algorithm. But some departures from the model can also lead to Hardy-Weinberg or linkage disequilibrium. These include inbreeding, and genotyping errors such as occasional, undetected, null alleles. Even in the absence of population structure, these types of factors can lead to a weak statistical signal for $ K>1$. Beginning in Version 2, we have suggested that the correlated allele frequency model should be used as a default because it often achieves better performance on difficult problems, but the user should be aware that this may make it easier to overestimate $ K$ in such settings than under the independent frequencies model. The next subsection discusses how to decide whether inferred structure is real.
next up previous contents
Next: Informal pointers for choosing Up: Estimation of (the number Previous: Steps in estimating   Contents
Jonathan Pritchard 2003-07-10