CME Grand Rounds Sanjiv Sam Gambhir Lectureship – “Imaging at the Speed of Light: Innovations in Positron Emission Tomography”
Simon R. Cherry, PhD
Professor
Biomedical Engineering & Radiology
UC Davis
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ABSTRACT
Positron emission tomography (PET) allows for sensitive and quantitative measurement of physiology, metabolism and molecular targets noninvasively in the human body. However, typical clinical PET scanners capture less than 1% of the available signal produced in the body. PET scanners also are not currently capable of precisely determining the location at which a particular decay occurs. These limitations present opportunities for further innovation that ultimately will impact molecular imaging research and diagnostic imaging with PET. This presentation focuses on 1) total-body PET imaging which greatly improves signal collection, allowing radiotracer kinetics to be assessed across the entire human body for the first time, and 2) the development of detector technologies that have a timing precision of ~ 30 picoseconds, enabling direct localization of radiotracer decays without tomographic reconstruction.
BIO
Simon R. Cherry, Ph.D. received his B.Sc.(Hons) in Physics with Astronomy from University College London in 1986 and a Ph.D. in Medical Physics from the Institute of Cancer Research, University of London in 1989. After a postdoctoral fellowship at UCLA, he joined the faculty in the Department of Molecular and Medical Pharmacology, also at UCLA, in 1993. In 2001, Dr. Cherry joined UC Davis and established the Center for Molecular and Genomic Imaging, which he directed from 2004-2016. Currently Dr. Cherry is Distinguished Professor in the Departments of Biomedical Engineering and Radiology at UC Davis.
Dr. Cherry’s research interests center around biomedical imaging and in particular the development and application of in vivo molecular imaging systems. His major accomplishments have been in developing systems for positron emission tomography (PET), in particular the invention of the microPET technology that was subsequently widely adopted in academia and industry and as co-leader of the EXPLORER consortium which has developed the world’s first total-body PET scanner. He also has contributed to detector technology innovations for PET, conducted early biomedical studies using Cerenkov luminescence, and developed the first proof-of-concept hybrid PET/MRI (magnetic resonance imaging) systems.
Dr. Cherry is a founding member of the Society of Molecular Imaging and an elected fellow of six professional societies, including the Institute for Electronic and Electrical Engineers (IEEE) and the Biomedical Engineering Society (BMES). He served as Editor-in-Chief of the journal Physics in Medicine and Biology from 2011-2020. Dr. Cherry received the Academy of Molecular Imaging Distinguished Basic Scientist Award (2007), the Society for Molecular Imaging Achievement Award (2011) and the IEEE Marie Sklodowska-Curie Award (2016). In 2016, he was elected as a member of the National Academy of Engineering and in 2017 he was elected to the National Academy of Inventors. Dr. Cherry is the author of more than 240 peer-reviewed journal articles, review articles and book chapters in the field of biomedical imaging. He is also lead author of the widely-used textbook “Physics in Nuclear Medicine”.
PHIND Seminar Series: Towards precision diagnostic and prediction of food allergy
Sindy KY Tang, Ph.D.
Associate Professor of Mechanical Engineering, Senior Fellow at the Woods Institute for the Environment and Professor, by courtesy, of Radiology – PHIND Center
Stanford University
Location: Zoom
Webinar URL: https://stanford.zoom.us/s/91932966334
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Webinar ID: 919 3296 6334
Passcode: 383071
11:00am – 12:00pm Seminar & Discussion
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ABSTRACT
Food allergy has reached epidemic proportions. Accurate in vitro methods that are efficient and easy to use to identify offending food allergens are lacking. Oral food challenge, the gold standard for food allergy assessment, is often not performed as it places the patient at risk of anaphylaxis. As such, food allergy is often identified only after an adverse reaction that could be life-threatening. Our long-term goal is to develop a food allergy diagnostic test that is accurate, safe, rapid, and accessible, so that food allergy can be easily identified prior to the occurrence of an adverse reaction, and that the efficacy of immunotherapy for food allergy can be tracked more effectively. This talk will discuss our recent work on developing such a test. Our approach is based on the Basophil Activation Test (BAT), which measures the activation of basophils in whole blood after stimulation with specific food allergens ex vivo. The BAT has been shown to be highly predictive of allergic reactions. However, the need for flow cytometry has limited its broader use. We are developing a miniaturized, standalone version of the BAT. We envision that the test can be used at the point of care, such as the doctor’s office or at a local pharmacy.
ABOUT
Prof. Sindy KY Tang is the Kenneth and Barbara Oshman Faculty Scholar and Associate Professor of Mechanical Engineering and by courtesy of Radiology (Precision Health and Integrated Diagnostics) at Stanford University. She received her Ph.D. from Harvard University in Engineering Sciences under the supervision of Prof. George Whitesides. Her lab at Stanford works on the fundamental understanding of fluid mechanics and mass transport in micro-nano systems, and the application of this knowledge towards problems in biology, rapid diagnostics for health and environmental sustainability. The current areas of focus include the flow physics of confined micro-droplets using experimental and machine learning methods, interfacial mass transport and self-assembly, and ultrahigh throughput opto-microfluidic systems for disease diagnostics, water and energy sustainability, and single-cell wound healing studies. She was a Stanford Biodesign Faculty Fellow in 2018. Dr. Tang’s work has been recognized by multiple awards including the NSF CAREER Award, 3M Nontenured Faculty Award, the ACS Petroleum Fund New Investigator Award, and invited lecture at the Nobel Symposium on Microfluidics in Sweden. Website: http://web.stanford.edu/group/tanglab/
Hosted by: Garry Gold, M.D.
Sponsored by the PHIND Center and the Department of Radiology
CME Grand Rounds Diversity Lectureship – Topic: TBD
Jennifer L. Eberhardt, PhD
Professor
Psychology
Stanford University
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Meeting ID: 600 003 703
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ABSTRACT
Coming soon!
BIO
Coming soon!
CME Grand Rounds – “Community Based Partnered Research: Revisiting a Critical Concept for Radiology”
Christoph L. Lee, MD, MS, MBA
Professor
Radiology
University of Washington
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Meeting ID: 600 003 703
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ABSTRACT
Coming soon!
BIO
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CEDSS: The First Cell: A new model for cancer research and treatment
Azra Raza, M.D.
Chan Soon-Shiong Professor of Medicine
Director, Myelodysplastic Syndrome Center
Columbia University Medical Center
Location: Zoom
Meeting URL: https://stanford.zoom.us/s/99340345860
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Meeting ID: 993 4034 5860
Passcode: 711508
ABSTRACT
Cancer research continues to be predicated on a 1970’s model of research and treatment. Despite half a century of intense research, we are failing spectacularly to improve the outcome for patients with advanced disease. Those who are cured continue to be treated mostly with the older strategies (surgery-chemo-radiation). Our contention is that the real solution to the cancer problem is to diagnose cancer early, at the stage of The First Cell. The rapidly evolving technologies are doing much in this area but need to be expanded. We study a pre-leukemic condition called myelodysplastic syndrome (MDS) with the hope that we can detect the first leukemia cells as the disease transforms to acute myeloid leukemia (AML). Towards this end, we have collected blood and bone marrow samples on MDS and AML patients since 1984. Today, our Tissue Repository has more than 60,000 samples. We propose novel methods to identify surrogate markers that can identify the First Cell through studying the serial samples of patients who evolve from MDS to AML.
ABOUT
Dr. Raza is a Professor of Medicine and Director of the MDS Center at Columbia University in New York, NY.She started her research in Myelodisplastic Syndromes (MDS) in 1982 and moved to Rush University, Chicago, Illinois in 1992, where she was the Charles Arthur Weaver Professor in Oncology and Director, Division of Myeloid Diseases. The MDS Program, along with a Tissue Repository containing more than 50,000 samples from MDS and acute leukemia patients was successfully relocated to the University of Massachusetts in 2004 and to Columbia University in 2010.
Before moving to New York, Dr. Raza was the Chief of Hematology Oncology and the Gladys Smith Martin Professor of Oncology at the University of Massachussetts in Worcester. She has published the results of her laboratory research and clinical trials in prestigious, peer reviewed journals such as The New England Journal of Medicine, Nature, Blood, Cancer, Cancer Research, British Journal of Hematology, Leukemia, and Leukemia Research. Dr. Raza serves on numerous national and international panels as a reviewer, consultant and advisor and is the recipient of a number of awards.
Hosted by: Utkan Demirci, Ph.D.
Sponsored by: The Canary Center & the Department of Radiology
Stanford University – School of Medicine
PHIND Seminar Series: Topic TBA
Christina Curtis, Ph.D.
Associate Professor of Medicine (Oncology) and of Genetics
Stanford University
Location: Venue coming soon!
11:00am – 12:00pm Seminar & Discussion
12:00pm – 12:15pm Reception
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ABSTRACT
Coming soon!
ABOUT
Coming soon!
Hosted by: Garry Gold, M.D.
Sponsored by the PHIND Center and the Department of Radiology
CME Grand Rounds – Topic: TBD
Jocelyn D. Chertoff, MD, MS
Professor
Radiology, Obstetrics & Gynecology
Chair, Radiology
Dartmouth Hitchcock Medical Center
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Meeting ID: 600 003 703
Password: 566048
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ABSTRACT
Coming soon!
BIO
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CME Grand Rounds Etta K. Moskowitz Lectureship – Topic: TBD
Elizabeth Krupinski, PhD
Professor & Vice Chair for Research
Radiology & Imaging Sciences
Emory University School of Medicine
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Meeting ID: 600 003 703
Password: 566048
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International numbers available: https://stanford.zoom.us/u/acuqphnvqT
ABSTRACT
Coming soon!
BIO
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CME Grand Rounds – “Promote Your Academic Career Using Social Media”
Michael Gisondi, MD
Associate Professor & Vice Chair of Education
Emergency Medicine
Stanford University
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Meeting ID: 600 003 703
Password: 566048
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International numbers available: https://stanford.zoom.us/u/acuqphnvqT
ABSTRACT
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BIO
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PHIND Seminar Series: Male Infertility and the Future Risk of Vascular and CV Disease
Michael Eisenberg, M.D.
Associate Professor of Urology and, by courtesy, of Obstetrics and Gynecology
Stanford University Medical Center
Gary M. Shaw, Ph.D.
NICU Nurses Professor and Professor, by courtesy, of Health Research and Policy (Epidemiology) and of Obstetrics and Gynecology (Maternal Fetal Medicine)
Stanford University
Location: Venue coming soon!
11:00am – 12:00pm Seminar & Discussion
12:00pm – 12:15pm Reception
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ABSTRACT
Coming soon!
ABOUT
Coming soon!
Hosted by: Garry Gold, M.D.
Sponsored by the PHIND Center and the Department of Radiology