“Tumor-Immune Interactions in TNBC Brain Metastases”
Maxine Umeh Garcia, PhD
ABSTRACT: It is estimated that metastasis is responsible for 90% of cancer deaths, with 1 in every 2 advanced staged triple-negative breast cancer patients developing brain metastases – surviving as little as 4.9 months after metastatic diagnosis. My project hypothesizes that the spatial architecture of the tumor microenvironment reflects distinct tumor-immune interactions that are driven by receptor-ligand pairing; and that these interactions not only impact tumor progression in the brain, but also prime the immune system (early on) to be tolerant of disseminated cancer cells permitting brain metastases. The main goal of my project is to build a model that recapitulates tumor-immune interactions in brain-metastatic triple-negative breast cancer, and use this model to identify novel druggable targets to improve survival outcomes in patients with devastating brain metastases.
“Classification of Malignant and Benign Peripheral Nerve Sheath Tumors With An Open Source Feature Selection Platform”
Michael Zhang, MD
ABSTRACT: Radiographic differentiation of malignant peripheral nerve sheath tumors (MPNSTs) from benign PNSTs is a diagnostic challenge. The former is associated with a five-year survival rate of 30-50%, and definitive management requires gross total surgical with wide negative margins in areas of sensitive neurologic function. This presentation describes a radiomics approach to pre-operatively identifying a diagnosis, thereby possibly avoiding surgical complexity and debilitating symptoms. Using an open-source, feature extraction platform and machine learning, we produce a radiographic signature for MPNSTs based on routine MRI.
Radiomics and Radio-Genomics: Opportunities for Precision Medicine
Zoom: https://stanford.zoom.us/j/99904033216?pwd=U2tTdUp0YWtneTNUb1E4V2x0OTFMQT09
Pallavi Tiwari, PhD
Assistant Professor of Biomedical Engineering
Associate Member, Case Comprehensive Cancer Center
Director of Brain Image Computing Laboratory
School of Medicine | Case Western Reserve University
Abstract:
In this talk, Dr. Tiwari will focus on her lab’s recent efforts in developing radiomic (extracting computerized sub-visual features from radiologic imaging), radiogenomic (identifying radiologic features associated with molecular phenotypes), and radiopathomic (radiologic features associated with pathologic phenotypes) techniques to capture insights into the underlying tumor biology as observed on non-invasive routine imaging. She will focus on clinical applications of this work for predicting disease outcome, recurrence, progression and response to therapy specifically in the context of brain tumors. She will also discuss current efforts in developing new radiomic features for post-treatment evaluation and predicting response to chemo-radiation treatment. Dr. Tiwari will conclude with a discussion on her lab’s findings in AI + experts, in the context of a clinically challenging problem of post-treatment response assessment on routine MRI scans.
Thursday MIPS Roundtable: Thera(g)nostics: Current clinical use and future needs
1:30-2:15 PM | Dr. Carina Mari Aparici, M.D.
Thera(g)nostics: Current clinical use and future needs
Bringing the clinical needs with preclinical research efforts
Clinical Professor of Radiology – Nuclear Medicine
Director, Targeted Radionuclide Therapy Program
Stanford University
2:15-2:30 PM | Dr. Gunilla Jacobson, Ph.D.
MIPS Theranostics Interest Group
How to join and learn more
Deputy Director
Molecular Imaging Program at Stanford, Radiology
Stanford University
MIPS Roundtables will be every Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
4/23 Meeting URL: https://stanford.zoom.us/j/639510777
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 639 510 777
Thursday MIPS Roundtable: Faculty Lab Showcase
1:30-2:00 PM | Dr. Guillem Pratx, Ph.D.
The Physical Oncology Lab
Assistant Professor of Radiation Oncology (Radiation Physics)
Stanford University
2:00-2:30 PM | Dr. Craig Levin, Ph.D.
Molecular Imaging Instrumentation Laboratory
Professor of Radiology and, by courtesy, of Physics,
of Electrical Engineering and of Bioengineering
Stanford University
MIPS Roundtables will be every Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
4/30 Meeting URL: https://stanford.zoom.us/j/630252651
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 630 252 651
Thursday MIPS Roundtable: Faculty Lab Showcase
1:30-2:00 PM | Dr. Raag Airan, M.D., Ph.D.
Airan Lab: Noninvasive Control of the Nervous System
Assistant Professor of Radiology and, by courtesy, of Materials Science and Engineering and of Psychiatry and Behavioral Sciences
Stanford University
2:00-2:30 PM | Dr. Daniel Spielman, Ph.D.
The Spielman Laboratory: In Vivo MR Spectroscopy and Multinuclear Imaging
Professor of Radiology and, by courtesy, of Electrical Engineering
Stanford University
MIPS Roundtables will be every Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
5/7 Meeting URL: https://stanford.zoom.us/j/91812578814
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 918 1257 8814
Thursday MIPS Roundtable: Faculty Lab Showcase
1:30-2:00 PM | Dr. Gozde Durmus, Ph.D.
Levitating Cells for Applications in Biology and Medicine
Assistant Professor of Radiology
Stanford University
2:00-2:30 PM | Dr. Ramasamy Paulmurugan, Ph.D.
Cellular Pathway Imaging Laboratory (CPIL)
Associate Professor of Radiology
Stanford University
MIPS Roundtables will be every Thursday through May from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
5/14 Meeting URL: https://stanford.zoom.us/j/97661102825
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 976 6110 2825
Thursday MIPS Roundtable: Faculty Lab Showcase
1:30-2:00 PM | Dr. Sandip Biswal, M.D.
Associate Professor of Radiology
Stanford University
2:00-2:30 PM | Dr. Lei Xing, Ph.D.
Xing Lab: Where Sciences & Engineering Meet Medicine
Jacob Haimson Professor and Professor, by courtesy, of Electrical Engineering
Stanford University
MIPS Roundtables will be every Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
5/21 Meeting URL: https://stanford.zoom.us/j/98018934679
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 980 1893 4679
Thursday MIPS Roundtable: Faculty Lab Showcase
1:30-2:00 PM | Dr. Jianghong Rao, Ph.D.
Cellular and Molecular Imaging Laboratory (CMIL)
Professor of Radiology and, by courtesy, of Chemistry
Stanford University
2:00-2:30 PM | Dr. Zhen Cheng, Ph.D.
Cancer Molecular Imaging Chemistry Laboratory (CMICL)
Associate Professor of Radiology
Stanford University
MIPS Roundtables will be every Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
5/28 Meeting URL: https://stanford.zoom.us/j/92834097988
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 928 3409 7988
Thursday MIPS Roundtable: Meet our MIPS Instructors
1:30-2:00 PM | Dr. Katie Wilson, Ph.D.
“Optical and Acoustic Molecular Imaging to Identify Lymph Node Metastasis in Head and Neck Cancer.”
Instructor, Radiology
Stanford University
2:00-2:30 PM | Dr. Corinne Beinat, Ph.D.
“Molecular Imaging of Tumor Metabolism”
Instructor, Radiology
Stanford University
MIPS Roundtables are every other Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
Please note Zoom information does change week to week.
6/11 Meeting URL: https://stanford.zoom.us/j/95475611159
Dial: +1 650 724 9799 or +1 833 302 1536
Meeting ID: 954 7561 1159
Thursday MIPS Roundtable: Faculty Lab Showcase
MIPS Roundtables are every other Thursday from 1:30-2:30pm showcasing various topics and are open to all interested.
1:30-2:00 PM | Dr. Brian Rutt, Ph.D.
Cellular & Molecular MRI Laboratory (CMMRIL)
Professor of Radiology
Stanford University
2:00-2:30 PM | Dr. Kathy Ferrara, Ph.D.
Ferrara Laboratory: Image-guided Drug Delivery
Professor of Radiology
Stanford University
Please note Zoom information does change week to week.
6/25 Webinar URL: https://stanford.zoom.us/j/91635637393?pwd=c09vUXYyeU5VeHJBaUJVRHQrT3FJdz09
Dial: +1 650 724 9799 or +1 833 302 1536
Webinar ID: 916 3563 7393
Webinar Password: 271364