![CCSB Seminar: Identifying and Rationally Modulating Cellular Drivers of Tumor Response @ Clark Center S360](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2019/10/Shalek_Feature_Justin_Knight_2018-300x122.jpg)
Alex K. Shalek, PhD
Pfizer-Laubach Career Development Associate Professor
Institute for Medical Engineering & Science
Department of Chemistry and Koch Institute
Massachusetts Institute of Technology
Abstract: While several methods exist for sampling tissues in clinical contexts, without high-fidelity tools for comprehensively profiling them, we are both limited in our capacity to understand how constituent cells and their interactions impact prognosis, and to select and develop precision therapeutics. Recent years have witnessed transformative and intersecting advances in nanofabrication and molecular biology that now enable deep profiling of low-input samples. Collectively, these afford new and exciting opportunities to study cellular heterogeneity, starting from the level of the single cell, and may unlock the diagnostic, prognostic, and discovery potential of clinical isolates. Illustratively, I will introduce how we can leverage single-cell genomic approaches – and, in particular, single-cell RNA-Seq – to explore the extensive functional diversity between cells, uncovering, from the “bottom-up,” distinct cell states and their molecular drivers. Moreover, I will discuss high-throughput experimental strategies and demonstrate, in the context of Acute Lymphoblastic Leukemia, how they can be leveraged to achieve the statistical power necessary to reconstruct intracellular circuits, enumerate and redefine cell states and types, and transform our understanding of cellular decision-making in health and disease on a genomic scale.
Bio: Alex K. Shalek is currently the Pfizer-Laubach Career Development Associate Professor at MIT, as well as a Core Member of the Institute for Medical Engineering and Science (IMES), an Associate Professor of Chemistry, and an Extramural Member of The Koch Institute for Integrative Cancer Research. He is also an Institute Member of the Broad Institute, an Associate Member of the Ragon Institute, an Assistant in Immunology at MGH, and an Instructor in Health Sciences and Technology at HMS. His research is directed towards the development and application of new technologies that facilitate understanding of how cells collectively perform systems-level functions in healthy and diseased states. Dr. Shalek received his bachelor’s degree summa cum laude from Columbia University and his Ph.D. from Harvard University in chemical physics under the guidance of Hongkun Park, and performed postdoctoral training under Hongkun Park and Aviv Regev (Broad/MIT). To date, his interdisciplinary research has focused on realizing and utilizing nanoscale manipulation and measurement technologies to examine how small components (molecules, cells) drive systems of vast complexity (cellular responses, population behaviors).
![MIPS IMAGinING THE FUTURE Seminar Series - Dr. Jennifer Doudna](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2019/10/jennifer-199x300.jpg)
Abstract: Gene editing with CRISPR technology is transforming biology. Understanding the underlying chemical mechanisms of RNA-guided DNA and RNA cleavage provides a foundation for both conceptual advances and technology development. I will discuss how bacterial CRISPR adaptive immune systems inspire creation of powerful genome editing tools, enabling advances in both fundamental biology and applications in medicine. I will also discuss the ethical challenges of some of these applications with a focus on what our decisions now might mean for future generations.
About: MIPS IMAGinING THE FUTURE seminar series is aimed at catalyzing interdisciplinary discussions in all area of medicine and disease. The seminar series is open and free to everyone in the Stanford community, as well as anyone from the surrounding community, companies or institutions. Our next seminar will host Dr. Jennifer Doudna, Professor of Chemistry, Biochemistry & Molecular Biology, &Li Ka Shing Chancellor’s Professor in Biomedical and Health, University of California, Berkeley; for her presentation on the “World of CRISPR: Editing Genomes and Altering Our Future”.
More Information: http://med.stanford.edu/radiology/imagining-the-future.html
Register: https://www.onlineregistrationcenter.com/JenniferDoudna
![Mini-Grand Rounds - Aruna Subramanian, MD, and David Ha, PharmD @ Zoom](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2020/03/subramanian-ha-300x300.jpg)
Mini-Grand Rounds: Emerging treatment strategies for COVID-19
Aruna Subramanian, MD
Clinical Professor, Medicine
Stanford University
David Ha, PharmD
Infectious Disease Resident
Stanford University
7:00am – 7:30am, Zoom
The Stanford Radiology Mini-Grand Round live session events are by invitation only. Invites with link to Zoom video will be sent via email to Department faculty and staff only. Recordings will be made available to the public shortly after the event.
![Mini-Grand Rounds - Payam Massaband, MD @ Zoom](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2020/03/payam-massaband-300x300.jpg)
Mini-Grand Rounds: Effective faculty-trainee workflow and education during the COVID-19 pandemic
Payam Massaband, MD
Clinical Associate Professor, Radiology
Stanford University
7:00am – 7:30am, Zoom
The Stanford Radiology Mini-Grand Round live session events are by invitation only. Invites with link to Zoom video will be sent via email to Department faculty and staff only. Recordings will be made available to the public shortly after the event.
![Mini-Grand Rounds - Michele Barry, MD, FACP @ Zoom](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2020/03/michele-barry-300x300.jpg)
Mini-Grand Rounds: CoVID19: Lessons learned from the global response
Michele Barry, MD, FACP
Drs. Ben & A. Jess Shenson Professor
Senior Associate Dean, Global Health
Director, Center for Innovation in Global Health
Professor of Medicine & Senior Fellow at the Woods Institute and at the Freeman Spogli Institute
7:00am – 7:30am, Zoom
The Stanford Radiology Mini-Grand Round live session events are by invitation only. Invites with link to Zoom video will be sent via email to Department faculty and staff only. Recordings will be made available to the public shortly after the event.
![Mini-Grand Rounds - Garry Gold, MD @ Zoom](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2020/03/garry-gold-300x300.jpg)
Mini-Grand Rounds: How to stay productive during the COVID-19 pandemic
Garry Gold, MD
Vice Chair, Research and Organization
Professor, Radiology
Stanford University
7:00am – 7:30am, Zoom
The Stanford Radiology Mini-Grand Round live session events are by invitation only. Invites with link to Zoom video will be sent via email to Department faculty and staff only. Recordings will be made available to the public shortly after the event.
![Mini-Grand Rounds - Shanthi Kappagoda, MD, MS](https://web.stanford.edu/group/radweb/cgi-bin/radcalendar/wp-content/uploads/2020/03/shanthi-kappagoda-300x300.jpg)
Mini-Grand Rounds: Update on COVID-19
Shanthi Kappagoda, MD, MS
Clinical Associate Professor, Medicine – Infectious Diseases
Stanford University
7:00am – 7:30am, Zoom
The Stanford Radiology Mini-Grand Round live session events are by invitation only. Invites with link to Zoom video will be sent via email to Department faculty and staff only. Recordings will be made available to the public shortly after the event.