Multi-cell Assemblies: Biophysics, Engineering, Programming, Interactivity

friedrich

 

friedrich

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Multi-cellularity enables organisms and symbiotic systems to achieve complex tasks through division of labor among cells. Such systems transcend current materials and electronics in many ways, e.g., they synthesize chemicals, generate active physical forms, and self-replicate. Harnessing these features promises significant impact for manufacturing (bioelectronics), health (tissue engineering), chemistry (pathway modularization), ecology (bioremediation), biodesign (art), and more. It is our vision that living multi-cell systems will become as programmable, interactive, constructible, and useful as our current electronic devices. We combine biophysics, synthetic biology, and interaction design to understand and programm multi-cell systems.

 

Selected publications:

  • Bioty: Programming paradigm for living matter PNAS 2019
  • Polygonal motion and phototaxis in microswimmers Nature Physics 2018
  • Synthetic cell-cell adhesion for programming multicell structures Cell 2018
  • Biofilm Lithography: Optogenetic cell-surface patterning PNAS 2018
  • Lego liquid handling robots PLoS Biology 2017
  • Massive online learning with real biology experimentation IJAIE 2017
  • Spatiotemporal programming of active particle swarms LabChip 2017
  • Realtime interactive biology cloud labs Nature Biotechnology 2016
  • Signaling delays and error correction in lateral inhibition patterning Phys Rev Lett 2016
  • LudusScope: Playful DIY smartphone microscopy PLoS1 2016
  • Design rules for interactive biotechnology DiGRA/FDG 2016
  • TrapIt! Human-Biology Interactive museum installation CHI 2015
  • Turnbased interactive biology cloud labs CHI 2015
  • Biotic game design course PLoS Biology 2015
  • Fluctutations of flagellar beating Phys Rev Lett 2014
  • Ethics of playing with living matter HCR 2014
  • Biotic games: Engineering, design, utility LabChip 2011
  • Synchrony dynamics, noise, and coupling in the segmentation clock Science 2007
  • Flagellar beat regulation by molecular motors and boundary conditions HFSP 2007
  • Self-organized sperm vortex arrays Science 2005