Mehta, N.; Meng, Y.; Zare, R.; Kamenetsky-Goldstein, R.; Sattely, E. S. “A developmental gradient reveals biosynthetic pathways to eukaryotic toxins in monocot geophytes” bioRxiv 2023

Khariton M, McClune CJ, Brower KK, Klemm S, Sattely ES, Fordyce PM, Wang B. “Alleviating Cell Lysate-Induced Inhibition to Enable RT-PCR from Single Cells in Picoliter-Volume Double Emulsion Droplets.” Anal. Chem. 2023

Carlson, E.; Rajniak, J.; Sattely, E. S. “Multiplicity of Agrobacterium infection of Nicotiana benthamiana for transient DNA delivery” bioRxiv 2023

De La Peña, R.* & Hodgson, H.* & Liu, J. C. T.*; Stephenson, M. J.; Martin, A. C.; Owen, C.; Harkess, A.; Leebens-Mack, J.; Jimenez, L. E.; Osbourn, A. & Sattely, E. S. “Complex scaffold remodeling in plant triterpene biosynthesis” Science 2023 doi:

– Highlight in C&EN

Kaseniit KE, Katz N, Kolber NS, Call CC, Wengier DL, Cody WB, Sattely ES, Gao XJ. “Modular, programmable RNA sensing using ADAR editing in living cells.” Nat. Biotech. 2022

Nett, R. S.*; Dho, Y.; Tsai, C.; Wonderlick, D.; Low, Y.-Y.; & Sattely, E. S.* “Neofunctionalized carbonic anhydrases in the biosynthesis of neuroactive plant alkaloids” bioRxiv 2022 doi: *co-corresponding authors

Kim, S.; Wengier, D.; Ragland, C.; & Sattely, E. S. “Transcriptional Reactivation of Lignin Biosynthesis for the Heterologous Production of Etoposide Aglycone in N. benthamiana” ACS Syn. Biol. 2022

Nett, R. S., & Sattely, E. S. “Total Biosynthesis of the Tubulin-Binding Alkaloid Colchicine.” Journal of the American Chemical Society 2021

Schnabel, T., & Sattely, E. “Improved Stability of Engineered Ammonia Production in the Plant-Symbiont Azospirillum brasilense.” ACS Synthetic Biology. 2021

– ACS Synthetic Biology issue cover art

Khlystov, N. A., Yoshikuni, Y., Deutsch, S., & Sattely, E. S. “A plant host enables the heterologous production and combinatorial study of fungal lignin-degrading enzymes.” Communications Biology 2021

Schnabel, T., & Sattely, E. S. “Engineering post-translational regulation of glutamine synthetase for controllable ammonia production in the plant-symbiont A. brasilense.” Applied and Environmental Microbiology 2021

– Highlight in Stanford Engineering

Nett, R. S., Dho, Y., Low, Y. Y., & Sattely, E. S. “A metabolic regulon reveals early and late acting enzymes in neuroactive Lycopodium alkaloid biosynthesis” PNAS 2021

Holmes, E. C.* & Chen, Y. C.*, Mudgett, M. B., & Sattely, E. S. “Arabidopsis UGT76B1 glycosylates N-hydroxy-pipecolic acid and inactivates systemic acquired resistance in tomato” The Plant Cell 2021

Kim, S. S. & Sattely, E. S. “Dirigent Proteins Guide Asymmetric Heterocoupling for the Synthesis of Complex Natural Product Analogues” J. Am. Chem. Soc. 2021

De La Peña, R. & Sattely, E. S. “Rerouting plant terpene biosynthesis enables momilactone pathway elucidation” Nat. Chem. Biol. 2020

– Highlight in C&EN

Nett, R. S.* & Lau, W.*; Sattely, E. S. “Discovery and engineering of colchicine alkaloid biosynthesis” Nature 2020

– Commentary in Nature by J.-K. Weng

Calgaro-Kozina, A.; Vuu, K. M.; Keasling, J. D.; Loque, D.; Sattely, E. S. & Shih, P. M. “Engineering plant synthetic pathways for the biosynthesis of novel antifungals” ACS Cent. Sci. 2020

Liou, C. S.* & Sirk, S. J.* & Diaz, C. A. C.*; Klein, A. P.; Fischer, C. R.; Higginbottom, S, K.; Erez, A.; Donia, H.; Sonnenburg, J. L.; Sattely, E. S.“A metabolic pathway for glucosinolate activation by the human gut symbiont Bacteroides thetaiotaomicron” Cell 2020

– Highlight in Nature 2020

Jeon, J-E.* & Kim, J-G.*; Fischer, C. R.; Dufour-Schroif, C.; Wemmer, K.; Mudgett, M. B. & Sattely, E. S.“A pathogen-responsive gene cluster for the production of highly modified fatty acids in tomato” Cell 2020

Schultz, B. J.; Kim, S. Y.; Lau, W.; Sattely, E. S. “Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis” J. Am. Chem. Soc. 2019

– Highlight in Nature Chemistry, 2020

Hodgson, H.* & De La Peña, R.*;Stephenson, M. J.; Thimmappa, R.; Vincent, J. L.; Sattely, E. S.; Osbourn, A. “Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production” PNAS 2019, 116, 117096-17104.

Holmes, E. C.* & Chen, Y-C*; Sattely, E. S. & Mudgett, M.B. “Conservation of N-hydroxy-pipecolic acid-mediated systemic acquired resistance in crop plants” Science Signaling 2019

Voges, M. J. E. E. E.; Bai, Y.; Schulze-Lefert, P.; Sattely, E. S. “Plant-derived coumarins shape the composition of an Arabidopsis synthetic root microbiome” PNAS 2019116, 12558-12565.

Nett, R. S.* & Guan, X.* & Smith, K.*; Faust, A. M.; Sattely, E. S. & Fischer, C. R.  “D2O Labeling to measure active biosynthesis of natural products in medicinal plants” AIChE J. – Tribute to Jay Bailey 2018

Chen, Y. C.* & Holmes, E.*; Rajniak, J.;  Kim, J-G.; Tang, S.; Fischer, C.; Mudgett, M. B. & Sattely, E. S. “N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis” PNAS 2018 doi: 10.1073/pnas.1805291115.

Rajniak, J.; Giehl, R. F.; Chang, E.; Murgia, I.; von Wiren, N.; Sattely, E. S. “Biosynthesis of redox-active metabolites in response to iron deficiency in plants” Nature Chem. Biol. 2018 doi:

Klein, A. P and Sattely, E. S. “Biosynthesis of cabbage phytoalexins from indole glucosinolate” Proc. Nat. Acad. Sci. 2017, doi: 10.1073/pnas.1615625114.

LeFevre, G. H.; Portmann, A. C.; Müller, C. E.; Sattely, E. S.; Luthy, R. G. “Plant Assimilation Kinetics and Metabolism of 2-Mercaptobenzothiazole Tire Rubber Vulcanizers by Arabidopsis” Environ. Sci. Technol. 2016, 13, 6762-6771.

Klein, A. P and Sattely, E. S. “Two Cytochromes P450 Catalyze S-Heterocyclizations in Cabbage Phytoalexin Biosynthesis” Nature Chem. Biol., 2015  doi:10.1038/nchembio.1914

Lau, W. and Sattely, E. S. “Six genes that complete biosynthetic pathway to the etoposide aglycone in Mayapple” Science, 2015, 349, 1224-1228.

News Features:

Stanford ChEM-H

Science Magazine News


Smithsonian Magazine

Rajniak, J; Barco, B.; Clay, N. K. & Sattely, E. S. “A New Cyanogenic Metabolite in Arabidopsis Required for Inducible Pathogen Defense” Nature, 2015525, 376-379.

Müller, C. E.; LeFevre, G. H.; Timofte, A. E.; Hussain, F. A.; Sattely, E. S.; Luthy, R. G.; “Competing mechanisms for perfluoroalkyl-acid accumulation in plants revealed using an Arabidopsis model system” Environ Toxicol Chem. 2015, doi: 10.1002/etc.3251.

LeFevre, G. H.; Muller, C. E.; Li, R. J.; Luthy, R. G.; Sattely, E. S. “Rapid Phytotransformation of Benzotriazole Generates Synthetic Tryptophan Analogs in Arabidopsis,” Environ. Sci. Technol. 2015, 49, 10959-10968.

Lau, W.; Fischbach, M. A.; Osbourn, A.; Sattely, E. S. “Key Applications of Plant Metabolic Engineering,” Plos Biology 2014, 12, e1001879.

Anarat-Cappillino, G.; Sattely, E. S. “The Chemical Logic of Plant Natural Product Biosynthesis” Curr. Opin. Plant Biol. 2014, 19, 51-58.

Klein, A. P.; Anarat-Cappillino, G.; Sattely, E. S. “Three Cytochromes P450 are Sufficient to Reconstitute the Biosynthesis of Camalexin, a Major Arabidopsis Antibiotic” Angew. Chem. Int. Ed. 2013, 52, 13625-13628.

Chung, Y-L.; Olsson, J. V.; Li, R. J.; Frank, C. W.; Waymouth, R. M.; Billington, S.; Sattely, E. S. “A Renewable Lignin-PLA Copolymer and Application in Biobased Composites,” ACS Sus. Chem. Eng. 2013, 10, 1231-1238


Heemstra Jr., J. R.; Walsh, C. T.; Sattely, E. S. “Enzymatic Tailoring of Ornithine in the Biosynthesis of the Rhizobium Cyclic Trihydroxamate Siderophore Vicibactin,” J. Am. Chem. Soc. 2009, 131, 15317-15329.

Wuest, W. M.; Sattely, E. S.; Walsh, C. T. “Three Siderophores from One Assembly Line Enzyme,” J. Am. Chem. Soc. 2009, 131, 5056-5057.

Sattely, E. S.; Meek, S. J.; Malcolmson, S. J.; Schrock, R. R.; Hoveyda, A. H. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine: Catalyst Development Inspired by Natural Product Synthesis,” J. Am. Chem. Soc. 2009, 131, 943- 953.

Malcolmson, S. J.; Meek, S. J.; Sattely, E. S.; Schrock, R. R.; Hoveyda, A. H. “Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis,” Nature 2008, 456, 933-937.

Sattely, E. S.; Walsh, C. T. “A Latent Oxazoline Electrophile for N-O-C Bond Formation in Pseudomonine Biosynthesis,” J. Am. Chem. Soc. 2008, 130, 12282-12284.

Sattely, E. S.; Fischbach, M. A.; Walsh, C. T. “Total Biosynthesis: in vitro Reconstitution of Polyketide and Nonribosomal Peptide Pathways,” Nat. Prod. Rep. 2008, 25, 757-793.

Sattely, E. S.; Cortez, G. A.; Moebius, D. C.; Schrock, R. R.; Hoveyda, A. H. “Enantioselective Synthesis of Cyclic Amines and Amides through Mo-Catalyzed Asymmetric Ring-Closing Metathesis,” J. Am. Chem. Soc. 2005, 127, 8526-8533.

Dolman, S. J.; Sattely, E. S.; Hoveyda, A. H.; Schrock, R. R. “Efficient Catalytic Enantioselective Synthesis of Unsaturated Amines: Preparation of Small- and Medium- Ring Cyclic Amines through Mo-Catalyzed Asymmetric Ring-Closing Metathesis in the Absence of Solvent,” J. Am. Chem. Soc. 2002, 124, 6991-6997.

La, D. S.; Sattely, E. S.; Ford, J. G.; Schrock, R. R.; Hoveyda, A. H. “Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis (AROM/CM) Reactions. Mechanism and Application to Enantioselective Synthesis of Functionalized Cyclopentanes,” J. Am. Chem. Soc. 2001, 123, 7767-7778.

La, D. S.; Ford, J. G.; Sattely, E. S.; Bonitatebus, P. J.; Schrock, R. R.; Hoveyda, A. H. “Tandem Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis,” J. Am. Chem. Soc. 1999, 121, 11603-11604.