Publications

Nett, R. S.* & Lau, W.*; Sattely, E. S. “Discovery and engineering of colchicine alkaloid biosynthesis” Nature 2020 https://doi.org/10.1038/s41586-020-2546-8

Commentary in Nature by J.-K. Weng: https://doi: 10.1038/d41586-020-01675-0

Calgaro-Kozina, A.; Vuu, K. M.; Keasling, J. D.; Loque, D.; Sattely, E. S. & Shih, P. M. “Engineering plant synthetic pathways for the biosynthesis of novel antifungals” ACS Cent. Sci. 2020 https://doi.org/10.1021/acscentsci.0c00241

Liou, C. S.* & Sirk, S. J.* & Diaz, C. A. C.*; Klein, A. P.; Fischer, C. R.; Higginbottom, S, K.; Erez, A.; Donia, H.; Sonnenburg, J. L.; Sattely, E. S.“A metabolic pathway for glucosinolate activation by the human gut symbiont Bacteroides thetaiotaomicron” Cell 2020 https://doi.org/10.1016/j.cell.2020.01.023

Highlight in Nature 2020: https://www.nature.com/articles/d41586-020-00493-8

Jeon, J-E.* & Kim, J-G.*; Fischer, C. R.; Dufour-Schroif, C.; Wemmer, K.; Mudgett, M. B. & Sattely, E. S.“A pathogen-responsive gene cluster for the production of highly modified fatty acids in tomato” Cell 2020https://authors.elsevier.com/a/1aNHcL7PXYXH8

Schultz, B. J.; Kim, S. Y.; Lau, W.; Sattely, E. S. “Total Biosynthesis for Milligram-Scale Production of Etoposide Intermediates in a Plant Chassis” J. Am. Chem. Soc. 2019, 141, 19231-29235. doi: https://doi.org/10.1021/jacs.9b10717

Highlight in Nature Chemistry, 2020https://doi-org.stanford.idm.oclc.org/10.1038/s41570-020-0166-3

Hodgson, H.* & De La Peña, R.*;Stephenson, M. J.; Thimmappa, R.; Vincent, J. L.; Sattely, E. S.; Osbourn, A. “Identification of key enzymes responsible for protolimonoid biosynthesis in plants: Opening the door to azadirachtin production” PNAS 2019, 116, 117096-17104.

Holmes, E. C.* & Chen, Y-C*; Sattely, E. S. & Mudgett, M.B. “Conservation of N-hydroxy-pipecolic acid-mediated systemic acquired resistance in crop plants” Science Signaling 2019 doi: https://doi.org/10.1126/scisignal.aay3066.

Voges, M. J. E. E. E.; Bai, Y.; Schulze-Lefert, P.; Sattely, E. S. “Plant-derived coumarins shape the composition of an Arabidopsis synthetic root microbiome” PNAS 2019116, 12558-12565.

Nett, R. S.* & Guan, X.* & Smith, K.*; Faust, A. M.; Sattely, E. S. & Fischer, C. R.  “D2O Labeling to measure active biosynthesis of natural products in medicinal plants” AIChE J. – Tribute to Jay Bailey 2018 https://doi.org/10.1002/aic.16413.

Chen, Y. C.* & Holmes, E.*; Rajniak, J.;  Kim, J-G.; Tang, S.; Fischer, C.; Mudgett, M. B. & Sattely, E. S. “N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis” PNAS 2018 doi: 10.1073/pnas.1805291115.

Rajniak, J.; Giehl, R. F.; Chang, E.; Murgia, I.; von Wiren, N.; Sattely, E. S. “Biosynthesis of redox-active metabolites in response to iron deficiency in plants” Nature Chem. Biol. 2018 doi: https://doi.org/10.1038/s41589-018-0019-2.

Klein, A. P and Sattely, E. S. “Biosynthesis of cabbage phytoalexins from indole glucosinolate” Proc. Nat. Acad. Sci. 2017, doi: 10.1073/pnas.1615625114.

LeFevre, G. H.; Portmann, A. C.; Müller, C. E.; Sattely, E. S.; Luthy, R. G. “Plant Assimilation Kinetics and Metabolism of 2-Mercaptobenzothiazole Tire Rubber Vulcanizers by Arabidopsis” Environ. Sci. Technol. 2016, 13, 6762-6771.

Klein, A. P and Sattely, E. S. “Two Cytochromes P450 Catalyze S-Heterocyclizations in Cabbage Phytoalexin Biosynthesis” Nature Chem. Biol., 2015  doi:10.1038/nchembio.1914

Lau, W. and Sattely, E. S. “Six genes that complete biosynthetic pathway to the etoposide aglycone in Mayapple” Science, 2015, 349, 1224-1228.

News Features:

Stanford ChEM-H

Science Magazine News

Reuters

Smithsonian Magazine

Rajniak, J; Barco, B.; Clay, N. K. & Sattely, E. S. “A New Cyanogenic Metabolite in Arabidopsis Required for Inducible Pathogen Defense” Nature, 2015525, 376-379.

Müller, C. E.; LeFevre, G. H.; Timofte, A. E.; Hussain, F. A.; Sattely, E. S.; Luthy, R. G.; “Competing mechanisms for perfluoroalkyl-acid accumulation in plants revealed using an Arabidopsis model system” Environ Toxicol Chem. 2015, doi: 10.1002/etc.3251.

LeFevre, G. H.; Muller, C. E.; Li, R. J.; Luthy, R. G.; Sattely, E. S. “Rapid Phytotransformation of Benzotriazole Generates Synthetic Tryptophan Analogs in Arabidopsis,” Environ. Sci. Technol. 2015, 49, 10959-10968.

Lau, W.; Fischbach, M. A.; Osbourn, A.; Sattely, E. S. “Key Applications of Plant Metabolic Engineering,” Plos Biology 2014, 12, e1001879.

Anarat-Cappillino, G.; Sattely, E. S. “The Chemical Logic of Plant Natural Product Biosynthesis” Curr. Opin. Plant Biol. 2014, 19, 51-58.

Klein, A. P.; Anarat-Cappillino, G.; Sattely, E. S. “Three Cytochromes P450 are Sufficient to Reconstitute the Biosynthesis of Camalexin, a Major Arabidopsis Antibiotic” Angew. Chem. Int. Ed. 2013, 52, 13625-13628.

Chung, Y-L.; Olsson, J. V.; Li, R. J.; Frank, C. W.; Waymouth, R. M.; Billington, S.; Sattely, E. S. “A Renewable Lignin-PLA Copolymer and Application in Biobased Composites,” ACS Sus. Chem. Eng. 2013, 10, 1231-1238

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Heemstra Jr., J. R.; Walsh, C. T.; Sattely, E. S. “Enzymatic Tailoring of Ornithine in the Biosynthesis of the Rhizobium Cyclic Trihydroxamate Siderophore Vicibactin,” J. Am. Chem. Soc. 2009, 131, 15317-15329.

Wuest, W. M.; Sattely, E. S.; Walsh, C. T. “Three Siderophores from One Assembly Line Enzyme,” J. Am. Chem. Soc. 2009, 131, 5056-5057.

Sattely, E. S.; Meek, S. J.; Malcolmson, S. J.; Schrock, R. R.; Hoveyda, A. H. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine: Catalyst Development Inspired by Natural Product Synthesis,” Sattely, E. S.; Meek, S. J.; Malcolmson, S. J.; Schrock, R. R.; Hoveyda, A. H. J. Am. Chem. Soc. 2009, 131, 943- 953.

Malcolmson, S. J.; Meek, S. J.; Sattely, E. S.; Schrock, R. R.; Hoveyda, A. H. “Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis,” Nature 2008, 456, 933-937.

Sattely, E. S.; Walsh, C. T. “A Latent Oxazoline Electrophile for N-O-C Bond Formation in Pseudomonine Biosynthesis,” J. Am. Chem. Soc. 2008, 130, 12282-12284.

Sattely, E. S.; Fischbach, M. A.; Walsh, C. T. “Total Biosynthesis: in vitro Reconstitution of Polyketide and Nonribosomal Peptide Pathways,” Nat. Prod. Rep. 2008, 25, 757-793.

Sattely, E. S.; Cortez, G. A.; Moebius, D. C.; Schrock, R. R.; Hoveyda, A. H. “Enantioselective Synthesis of Cyclic Amines and Amides through Mo-Catalyzed Asymmetric Ring-Closing Metathesis,” J. Am. Chem. Soc. 2005, 127, 8526-8533.

Dolman, S. J.; Sattely, E. S.; Hoveyda, A. H.; Schrock, R. R. “Efficient Catalytic Enantioselective Synthesis of Unsaturated Amines: Preparation of Small- and Medium- Ring Cyclic Amines through Mo-Catalyzed Asymmetric Ring-Closing Metathesis in the Absence of Solvent,” J. Am. Chem. Soc. 2002, 124, 6991-6997.

La, D. S.; Sattely, E. S.; Ford, J. G.; Schrock, R. R.; Hoveyda, A. H. “Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis (AROM/CM) Reactions. Mechanism and Application to Enantioselective Synthesis of Functionalized Cyclopentanes,” J. Am. Chem. Soc. 2001, 123, 7767-7778.

La, D. S.; Ford, J. G.; Sattely, E. S.; Bonitatebus, P. J.; Schrock, R. R.; Hoveyda, A. H. “Tandem Catalytic Asymmetric Ring-Opening Metathesis/Cross Metathesis,” J. Am. Chem. Soc. 1999, 121, 11603-11604.