Selected Publications

(click on names for a PDF file of the paper)

Li J, Duarte T, Kocabas A, Works M, McConnell SK, Hynes MA (2014) Evidence for topographic guidance of dopaminergic axons by differential Netrin-1 expression in the striatum. Molec. Cell Neurosci. doi: 10.1016/j.mcn.2014.05.003. [Epub ahead of print].

Leone DP, Heavner WE, Ferenczi EA, Dobreva G, Huguenard JR, Grosschedl R, McConnell SK (2014) Satb2 regulates the differentiation of both callosal and sub cerebral projections neurons in the developing cerebral cortex. Cerebral Cortex poi:bhu156 [Epub ahead of print].

Srinivasan K, Leone DP, Bateson RK, Dobreva G, Kohwi Y, Kohwi-Shigematsu T, Grosschedl R, McConnell SK (2012) A network of genetic repression and derepression specifies projection fates in the developing neocortex. Proc. Natl. Acad. Sci. USA 109:19071-19078.

Harwell CC, Parker PRL, Gee SM, Okada A, McConnell SK, Kreitzer AC, Kriegstein AR (2012) Sonic hedgehog expression in corticofugal projection neurons directs cortical microcircuit formation. Neuron 22:1116-1126.

Wilson SL, Wilson JP, Wang C, Wang B, McConnell SK (2011) Primary cilia and Gli3 regulate cerebral cortical size. Dev. Neurobiol. doi:10.1002/dneu.20985.

Eckler MJ, McKenna WL, Taghvaei S, McConnell SK, Chen B (2011) Fezf1 and Fezf2 are required for olfactory development and sensory neuron identity. J. Comp. Neurol. 519:1829-1846.

Shieh JC, Schaar BT, McConnell SK (2011) Endocytosis regulates cell soma translocation and the distribution of adhesion proteins in migrating neurons. PLoS ONE 6:e17802.

Cord BJ, Li J, Works M, McConnell SK, Palmer T, Hynes MA (2010) Characterization of axon guidance cue sensitivity of human embryonic stem cell-derived dopaminergic neurons. Molec. Cell Neurosci. 45:324-334.

Leone DP, Srinivasan K, Brakebusch C, McConnell SK (2010) The Rho GTPase Rac1 is required for proliferation of intermediate progenitors in the developing forebrain. Dev. Neurobiol. 70:659-678.

Haditsch U, Leone DP, Farinelli M, Chrostek-Grashoff A, Brakebusch C, Mansuy IM, McConnell SK, Palmer TD (2009) A central role for the small GTPase Rac1 in hippocampal plasticity and spatial learning and memory. Molec. Cell. Neurosci. 41:409-419.

Chen B, Wang SS, Hattox AM, Rayburn H, Nelson SB, McConnell SK (2008) The Fezf2-Ctip2 genetic pathway regulates the fate choice of layer 5 subcortical projection neurons. Proc. Natl. Acad. Sci. USA 105:11382-11387.

Leone DP, Srinivasan K, Chen B, Alcamo E, McConnell SK (2008) The determination of projection neuron identity in the developing cerebral cortex. Curr. Opin. Neurobiol. 18:28-35.

Srinivasan S, Roosa J, Olsen O, Lee SH, Bredt DS, McConnell SK (2008) MALS-3 regulates polarity and early neurogenesis in the developing cerebral cortex. Development 135: 1781-1790.

Alcamo EA, Chirivella L, Dautzenberg M, Dobreva G, Fariñas G, Grosschedl R, McConnell SK (2008) SATB2 regulates callosal projection neuron identity in the developing cerebral cortex. Neuron 57:364-377.

Hayhurst M, Gore BB, Tessier-Lavigne M, McConnell SK (2008) Ongoing Sonic hedgehog signaling is required for dorsal midline formation in the developing forebrain. Devel. Neurobiol., 68:83-100.

Fernandes M, Gutin G, Alcorn H, McConnell SK, Hébert JM (2007) Mutations in the BMP pathway in mice support the existence of two molecular classes of holoprosencephaly. Development 134:3789-3794.

Okada A, Charron F, Morin S, Shin DS, Wong K, Fabre P, Tessier-Lavigne M, McConnell SK (2006) Boc is a receptor for Sonic Hedgehog in the guidance of commissural axons toward the ventral midline. Nature 444:369-373.

Gutin G, Fernandes M, Ornitz D, McConnell SK, Hébert JM (2006) FGF signaling generates ventral telencephalic cells independently of SHH. Development 133: 2937-2946.

Storm E, Garel S, Borello U, Hébert JM, Martinez S, McConnell SK, Martin GR, Rubenstein JLR (2006) Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development 133:1831-1844.

Ohtsuka T, Imayoshi I, Kageyama R, McConnell SK (2006) Visualization of embryonic neural stem cells using Hes promoters in transgenic mice. Molec. Cell. Neurosci. 31:109-122.

Chen B, Schaevitz LR, McConnell SK (2005) Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. Proc. Natl. Acad. Sci. USA 102:17184-17189.

Kawauchi S, Shou J, Santos R, Hébert JM, McConnell SK, Mason I, Calof AL (2005) Fgf8 expression defines a morphogenetic center required for olfactory neurogenesis and nasal cavity development in the mouse. Development 132:5211-5223.

Schaar BT, McConnell SK (2005) Cytoskeletal coordination during neuronal migration. PNAS 102:13652-13657.

Friedel RH, Plump A, Lu X, Spilker K, Jolicoeur C, Wong K, Venkathesh TR, Yaron A, Hynes M, Chen B, Okada A, McConnell SK, Rayburn H, Tessier-Lavigne M (2005) Gene targeting using a promoterless gene trap vector (“targeted trapping”) is an efficient method to mutate a large fraction of genes. PNAS 102:13188-13193.

Sansom SN, Hébert JM, Thammongkol U, Smith J, Nisbet G, Surani MA, McConnell SK, Livesey FJ (2005) Genomic characterisation of an FGF-regulated gradient-based cortical protomap. Development 132:3947-61.

Schaar BT, Kinoshita K, McConnell SK (2004) Doublecortin microtubule affinity is regulated by a balance of kinase and phosphatase activity at the leading edge of migrating neurons. Neuron 41:203-213.

Hayhurst M, McConnell SK (2003) Mouse models of holoprosencephaly. Curr. Opin. Neurol. 16:135-141.

Hébert JM, Hayhurst M, Marks ME, Kulessa H, Hogan BLM, McConnell SK (2003) BMP ligands act redundantly to pattern the dorsal telencephalic midline. Genesis 35:214 -219.

Hébert JM, Lin M, Partanen J, Rossant J, McConnell SK (2003) FGF signaling through FGFR1 is required for olfactory bulb morphogenesis. Development 130:1101-1111.

Hébert JM, Mishina Y, McConnell SK (2002) BMP signaling is required locally to pattern the dorsal telencephalic midline. Neuron 35:1029-1041.

Ferguson KL, Vanderluit JL, Hébert JM, McIntosh WC, Tibbo E, Park DS, Wallace V, Vooijs M, McConnell SK, Slack RS (2002) Telencephalic-specific Rb knockouts reveal enhanced neurogenesis, survival and abnormal forebrain development. EMBO J. 21: 3337-3346.

Pirvola U, Ylikoski J, Trokovic R, Hébert J, McConnell SK, Partanen J (2002) FGFR1 is required for the development of the auditory sensory epithelium. Neuron 35: 671-680.

Anderson SA, Kaznowski CE, Horn C, Rubenstein JL, McConnell SK (2002) Distinct origins of neocortical projection neurons and interneurons in vivo. Cereb. Cortex 12:702-709.

Zhang YA, Okada A, Lew CH, McConnell SK (2002) Regulated nuclear trafficking of the homeodomain protein Otx1 in cortical neurons. Molec. Cell. Neurosci. 19:430-446.

Aumais JP, Tunstead JR, McNeil R, Schaar BT, McConnell SK, Lin S-H, Clark GD, Yu-Lee LY (2001) NudC associates with Lis1 and the dynein motor at the leading pole of migrating neurons. J. Neurosci. 21: RC187.

Friocourt G, Chafey P, Billuart P, Koulakoff A, Vinet MC, Schaar B, McConnell SK, Francis F, Chelly J (2001) Doublecortin interacts with µ subunits of clathrin adaptor complexes in the developing nervous system. Molec. Cell. Neurosci. 18:307-19.

Cahana A, Escamez T, Nowakowski RS, Hayes NL, Giacobini MB, von Holst A, Shmueli O, Sapir T, McConnell SK, Wurst W, Martinez S, Reiner O (2001) Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization. Proc. Natl. Acad. Sci. USA 98:6429-6434.

Chenn A, Levin ML, McConnell SK (2001) Restricted cerebral cortex expression of a candidate G-protein coupled receptor isolated by PCR differential display. J. Neurobiol. 46:167-177.

Mulieri PJ, Okada A, Sassoon DA, McConnell SK, Krauss RS (2000) Developmental expression pattern of the cdo gene. Devel. Dynamics 219:40-49.

Hébert JM, McConnell SK (2000) Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Devel. Biol. 222:296-306.

Xu B, Zang K, Raff NL, Antonini A, Zhang YA, McConnell SK, Stryker MP, Reichardt LF (2000) Cortical degeneration in the absence of neurotrophin signaling: Dendritic retraction and neuronal loss after removal of the neurotrophin receptor TrkB. Neuron 26:233-245.

Desai AR, McConnell SK (2000) Progressive restriction in fate potential by neural progenitors during cerebral cortical development. Development 127:2863-2872.

Weimann JM, Zhang YA, Levin ME, Devine P, Brulet P, McConnell SK (1999) Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets. Neuron 24:819-831.

Mackarehtschian K, Lau CK, Caras I, McConnell SK (1999) Regional differences in the developing cerebral cortex revealed by ephrin-A5 expression. Cerebral Cortex 9:601-610.

Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, Vinet M-C, Friocourt G, McDonnell N, Reiner O, Kahn A, McConnell SK, Berwald-Netter Y, Denoulet P, Chelly J (1999) Doublecortin is a developmentally regulated, mictrotubule-associated protein expressed in migrating and differentiating neurons. Neuron 23:247-256.

Okada A, Lansford R, Weimann JM, Fraser SE, McConnell SK (1999) Imaging cells in the developing nervous system with retrovirus expressing modified Green Fluorescent Protein. Exp. Neurol. 156:394-406.

Chenn A, Zhang YA, Chang BT, McConnell SK (1998) Intrinsic polarity of mammalian neuroepithelial cells. Molec. Cell. Neurosci. 11:183-193.

Caric D, Gooday D, Hill RE, McConnell SK, Price DJ (1997) Determination of the migratory capacity of embryonic cortical cells lacking the transcription factor Pax-6. Development 124:5087-5096.

O'Rourke NA, Chenn A, McConnell SK (1997) Postmitotic neurons migrate tangentially in the cortical ventricular zone. Development 124:997-1005.

Bohner AP, Akers RM, McConnell SK (1997) Induction of deep layer cortical neurons in vitro. Development 124:915-923.

Frantz GD, McConnell SK (1996) Restriction of late cerebral cortical progenitors to an upper-layer fate. Neuron 17:55-61.

Chenn A, McConnell SK (1995) Cleavage orientation and the asymmetric inheritance of Notch1 immunoreactivity in mammalian neurogenesis. Cell 82:631-641.

O’Rourke NA, Sullivan DP, Kaznowski CE, Jacobs AA, McConnell SK (1995) Tangential migration of neurons in the developing cerebral cortex. Development 121: 2165-2176.

Frantz GD, Weimann JM, Levin ME, McConnell SK (1994) Otx1 and Otx2 define layers and regions in developing cerebral cortex and cerebellum. J. Neurosci. 14: 5725-5740.

Frantz GD, Bohner AP, Akers RM, McConnell SK (1994) Regulation of the POU-domain gene SCIP during cerebral cortical development. J. Neurosci. 14:472-485.

O'Rourke NA, Dailey ME, Smith SJ, McConnell SK (1992) Diverse migratory pathways in the developing cerebral cortex. Science 258:299-302.

McConnell SK, Kaznowski CE (1991) Cell cycle dependence of laminar determination in developing cerebral cortex. Science 254:282-285.

McConnell SK (1988) Fates of visual cortical neurons in the ferret after isochronic and heterochronic transplantation. J. Neurosci. 8:945-74.

McConnell SK (1985) Migration and differentiation of cerebral cortical neurons after transplantation into the brains of ferrets. Science 229:1268-1271.