Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3. Kornienko J; Rodríguez-Martínez M; Fenzl K; Hinze F; Schraivogel D; Grosch M; Tunaj B; Lindenhofer D; Schraft L; Kueblbeck M; Smith E; Mao C; Brown E; Owens A; Saguner AM; Meder B; Parikh V; Gotthardt M; Steinmetz LM. Nat Commun (2023). DOI
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy. Grosch M; Schraft L; Chan A; Küchenhoff L; Rapti K; Ferreira AM; Kornienko J; Li S; Radke MH; Krämer C; Clauder-Münster S; Perlas E; Backs J; Gotthardt M; Dieterich C; van den Hoogenhof MMG; Grimm D; Steinmetz LM. Nat Commun (2023). DOI
Transcriptional neighborhoods regulate transcript isoform lengths and expression levels. Brooks A*, Hughes A*, Clauder-Muenster S, Mitchell L, Boeke J, Steinmetz LM#. Science (2022). DOI
High-speed fluorescence image-enabled cell sorting. Schraivogel D, Kuhn TM, Rauscher B, Rodríguez-Martínez M, Paulsen M, Owsley K, Middlebrook A, Tischer C, Ramasz B, Ordoñez-Rueda D, Dees M, Cuylen-Haering S#, Diebold E#, Steinmetz LM#. Science (2022). DOI
Single-molecule, full-length transcript isoform sequencing reveals disease-associated RNA isoforms in cardiomyocytes. Zhu C*, Wu J*, Sun H, Briganti F, Meder B, Wei W, Steinmetz LM. Nature Commun (2021). DOI
Targeted Perturb-seq enables genome-scale genetic screens in single cells. Schraivogel D*, Gschwind AR*, Milbank JH, Leonce DR, Jakob P, Mathur L, Korbel JO, Merten CA, Velten L, Steinmetz LM. Nature methods (2020). DOI | PubMed 
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization. Baccin C*, Al-Sabah J*, Velten L*, Helbling PM, Grünschläger F, Hernández-Malmierca P, Nombela-Arrieta C, Steinmetz LM, Trumpp A, Haas S. Nature cell biology (2019). DOI
Cytosine base editor generates substantial off-target single nucleotide variants in mouse embryos. Zuo E*, Sun Y*, Wei W*, Yuan T*, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Science. (2019). DOI
Multiplexed precision genome editing with trackable genomic barcodes in yeast. Roy KR*, Smith JD*, Vonesch SC*, Lin G, Tu CS, Lederer AR, Chu A, Suresh S, Nguyen M, Horecka J, Tripathi A, Burnett WT, Morgan MA, Schulz J, Orsley KM, Wei W, Aiyar RS, Davis RW, Bankaitis VA, Haber JE, Salit ML, St Onge RP, Steinmetz LM. Nature Biotechnology (2018). DOI
Human haematopoietic stem cell lineage commitment is a continuous process. Velten L*, Haas SF*, Raffel S*, Blaszkiewicz S, Islam S, Hennig BP, Hirche C, Lutz C, Buss EC, Nowak D, Boch T, Hofmann WK, Ho AD, Huber W, Trumpp A, Essers MAG, Steinmetz LM. Nat Cell Biol. (2017). DOI
Widespread co-translational RNA decay reveals ribosome dynamics. Pelechano V*, Wei W*, Steinmetz LM. Cell. (2015). DOI
Extensive transcriptional heterogeneity revealed by isoform profiling. Pelechano, V., Wei, W. & Steinmetz, L.M. Nature. (2013). DOI
The Genomic and Transcriptomic Landscape of a HeLa Cell Line. Landry, J.J., Pyl, P.T., Rausch, T., Zichner, T., Tekkedil, M.M., Stütz, A.M., Jauch, A., Aiyar, R.S., Pau, G., Delhomme, N., Gagneur, J., Korbel, J.O., Huber, W. & Steinmetz, L.M. G3: Genes | Genomes | Genetics (2013). DOI 
Dissecting the genetic basis of resistance to malaria parasites in Anopheles gambiae. Blandin, S.A., Wang-Sattler, R., Lamacchia, M., Gagneur, J., Lycett, G., Ning, Y., Levashina, E.A. & Steinmetz, L.M. Science (2009) DOI
Bidirectional promoters generate pervasive transcription in yeast. Xu, Z., Wei, W., Gagneur, J., Perocchi, F., Clauder-Muenster, S., Camblong, J., Guffanti, E., Stutz, F., Huber, W., & Steinmetz, L.M. Nature (2009) DOI
High-resolution mapping of meiotic crossovers and noncrossovers in yeast. Mancera, E., Bourgon, R., Brozzi, A., Huber, W. & Steinmetz, L.M. Nature (2008). DOI
A high-resolution map of transcription in the yeast genome. David, L., Huber, W., Granovskaia, M., Toedling, J., Palm, C. J., Bofkin, L., Jones, T., Davis R.W. & Steinmetz, L.M. Proc. Natl. Acad. Sci. USA (2006) DOI
Dissecting the architecture of a quantitative trait locus in yeast. Steinmetz LM*, Sinha H, Richards DR, Spiegelman JI, Oefner PJ, McCusker JH, Davis RW. Nature. (2002). DOI