Wyss-Coray Lab

News Flash!!
  • Cognitive benefits of exercise can be transferred to a non-exercising mouse by blood plasma transfusion! Check out the preprint from Zuri and Mike on BioRxiv.
  • Benoit's new paper preprint on BioRxiv describes waves of aging in the human plasma proteome, with the first major wave in the mid 30’s!! - based on >4,300 people and 2,900 proteins
  • Julia's paper is out on BioRxiv! Alzheimer saw these cells back in 1906, and they were forgotten for 113 years. Now Julia has rediscovered them complete with an exhaustive characterization.
  • Hanadie's paper was published in Nature Medicine! She found that blocking VCAM1 circulating in blood with an antibody can counteract the cognitive deficits that occur in aged mice.
  • John's paper was published in Nature! Starting with an initial CRISPR screen, he found that blocking CD22 with an antibody restored homeostatic microglial phagocytosis and cognitive function in aged mice.
  • Tony has been appointed as the D. H. Chen Endowed Professor and will receive an official Stanford wooden chair with this honor.
  • Stanford received a $9.6 million award led by Tony from The American Heart Association and Allen Institute to treat dementia by targeting vascular function. If successful, this work could possibly generate the first effective treatment for Alzheimer’s Disease.
  • Tony was named as one of the 50 Most Influential People in Health Care by Time Magazine!
  • Andrew's discovery of two tRNA synthetases that can be used to label proteins in mammalian cells with click tyrosine or click phenylalanine was just published in JACS. I have a feeling the bio-orthogonal labeling field will be excited about this one!
Wyss-Coray Lab

The Wyss-Coray research team studies brain aging and neurodegeneration with a focus on age-related cognitive decline and Alzheimer’s disease. The team is studying how circulatory blood factors can modulate brain structure and function and how factors from young organisms can rejuvenate old brains. We are trying to understand the molecular basis of the systemic communication with the brain by employing a combination of genetic, cell biology, and –omics approaches in killifish, mice, and humans and through the development of bio-orthogonal tools for the in vivo labeling of proteins.

Affiliations and Support:

The Wyss-Coray lab is part of the Glenn Center for Aging at Stanford, the Stanford Neurosciences Institute’s Brain Rejuvenation Project, The NIH Alzheimer’s Disease Research Center, and it is funded by the Department of Veterans Affairs, the National Institute on Aging, the Cure Alzheimer’s Fund, and the NOMIS Foundation.

More on the lab can be found here:

New Yorker article
TED Talk
News Feature in Nature
article in The Guardian