1951--Isoloation of a virus which would later be classified as a reovirus (type 3) was made by Stanley, Dorman, and Ponsford from a young aboriginal child.

1953--An ECHO 10 virus, which would later become the prototypic reovirus serotype 1 strain, was isolated from a rectal swab taken from a healthy child.

1959--Proposal by Sabin that a group of previously classified members of the echovirus 10 group be reclassified in a new family. He proposed the name reovirus (respiratory, enteric, orphan virus) as the virus was not known to cause any known disease state.

1960-- An outbreak of infection with T1 reoviurses among children in a welfare institution in Washington D.C. was documented by Rosen and co-workers.

1960s--Unique virion of the RNA of the Reoviridae family was discovered.

Early 1970s--Orboviruses, which were previouldy classified as "unclassified arboviruses," were included in the Reoviridae family.

1973-- Bishop and co-workers discovered the 70 nm human rotavirus and its association with severe diarrhea in infants and young children.

Mid-late 1970s--Rotaviruses also became part of the Reoviridae family as it was realized that they had a segmented dsRNA genome. Three other genera which infect insects and plants (Cypovirus, Phytoreovirus, Fijivirus) which also have dsRNA became included in the Reoviridae family.

1978--Oral Rehydration therapy (ORT) was found to be useful in treating and preventing most of the deaths due to Rotavirus. Previous to this treatment for severe Rotavirus was intravenous electrolyte replacement, a costly and largely unavailabe treatment to those in need. The World Health Organization (WHO) began promoting it extensively.

1998--Found Rotaviruses cause as many as one million hospitalizations and 500 deaths per year in the US.

1997--A rotavirus ELISA was developed by Robert Yolken and co-workers.

1998--A tetravalent vaccine was approved by the FDA for use in infants.