Norvir is the brand name for the drug ritonavir produced by Abbot
Laboratories Inc. It is an HIV protease inhibitor for use against HIV
Ritonavir inhibits the ability of HIV protease to cleave the
gag-pol polyprotein, leading to the development of noninfectious,
immature viral particles. It is effective against both HIV-1 and
Norvir is indicated for use in combination therapy with other
antiretroviral agents or as a monotherapy against HIV infection.
Norvir is to be taken orally with meals if possible. The
recommended dosage for adults is 600 mg twice daily. To reduce
adverse effects, it can be started at 300 mg twice daily and
increased 100 mg twice daily until the 600 mg target is reached.
For pediatric patients, the the recommended dosage is 400 mg/sq.
m twice daily, no to exceed 600 mg twice daily. Dosage should
start at 250 mg/sq. m and be increased every 2 to 3 days by 50
mg/sq.m twice daily.
Ritonavir is processed primarily by the liver and care should
be taken when adminstering it to patients with impaired hepatic
Norvir is contraindicated for patients with known
hypersensitivity to ritonavir or any of its ingredients. it
shouldn ot be adminstered concomitantly ith amiodorane,
astemizole, bepridil, bupropion, cisapride, clozapine,
dihydroergotamine, encainide, ergotamine, flecainide, meperidine,
pimozide, piroxicam, propafenone, propoxyphene, quinidine,
rifabutin, terfenadine, clorazepate, diazepam, estazolam,
flurazepam, midazolam, triazolam, and zolpidem.
Potential Adverse Effects
The most common adverse effect of treatment is nausea.