Viral Profiles

Virus Incubation Period Epidemiology Symptoms and Outcome Prevention and Management
(Argentine Hemorrhagic Fever)

GUANARITO (Venezuelan Hemorrhagic Fever)

(Brazilian Hemorrhagic Fever)
7-14 days Spread via the respiratory route or by direct contact with the excretus of the natural hosts: voles (Calomys musculinus and C. laucha) and wild rodents. Malaise and fever develop 14-16 days after infection. Disease progresses to a hemorrhagic fever which includes thrombocytopenia, leukopenia, hemorrhage, hemoconcentration, proteinuria, and hypotension. Death from hypovolemic shock occurs in 5-35% of all cases. Prevention techniques include reducing contact between humans and rodents, especially within homes. A live attenuated vaccine for Junin is currently in human trials. Both Junin and Guanarito have been sensitive to ribavirin in vitro, although the effects of this antiviral agent on infected humans is not yet known. Ribavirin has proven to be an effective post-exposure prophylaxis for Sabia infection. Immune globulin is used to treat patients infected with the Junin virus.

Arenavirus 2000 Home
Humans and Viruses
Human Biology 115A
Winter, 2000
Robert Siegel, instructor


Created: February 1, 1998
Last modified: February 28, 2000