JCV AND PML:
Two Peas in a
80-85% of the population is exposed
to the virus.
There is not set incubation time
for the disease. PML (Progressive Multifocal Leukoencephalopathy) is a
syndrome associated with the disease. It emerges in immunosuppressed
individuals such as patients with AIDS or people with leukemia.
Brain biopsy- virus presence
brain is positive confirmation.
MRI (Magnetic Resonance Imaging)- lesions can be
CSF(cerebral spinal fluid taken from a
spinal tap)- virus
presence can be detected by
dementia, muscular weakness, vision and speech
Very few people spontaneous recover stabilize.
The disease is progressive and most die within 3-7
PATHOLOGY AND PATHOGENESIS:
invades the CNS.
Clinical symptoms are caused by lesions
in the brain.
PREVENTION AND MANGEMENT:
There is no vaccine against
Some antivirals have been used
to treat PML. It seems that
Ara-C can be effective in