Parvoviridae Properties

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Type Species: Minute Virus of Mice

Genome: Single stranded, linear DNA, ~5 kb

Click to enlarge genomes: (11)

Strandedness: Primarily negative strands in virion

Genes: Nonstructural (replication) and capsid

Presence of Envelope: None

Capsid: Icosahedral, T=1

Segments: Monopartite

Size: Very small (generally considered the smallest, physically, of the DNA viruses)

Kinetic classes: one

Capsid Proteins: VP1, VP2, VP3

Replication Strategy: Parvoviruses replicate in the nucleus and must wait until the cell is in S phase before reproducing themselves. The viruses utilize hairpin structures (using terminal palindromes) to replicate and solve the "tip problem." The genome folds back in on itself and self-primes to allow complementary strand synthesis (steps 1-4), a hairpin forms to allow for further DNA replication (5-6), and a dimer replicative intermediate is formed (7).

Cont. below


Next, a nuclease (NS1) cuts itself out and attaches to the 5' end. DNA synthesis continues until replication is complete. The new strand separates and becomes packaged in a capsid.



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Sequenced Genome: Here

Taxonomy: (2)

Family: Parvoviridae



Densovirinae (invertebrates)



Parvirinae genera: