MACHUPO VIRUS (Bolivian Hemorrhagic Fever)
Taxonomy: Order Mononegavirales; Family Arenaviridae; Subfamily New World Arenavirus
Morphology: enveloped, helical nucleocapsid; pleiomorphic in shape; "sandy" appearance
Genome: ssRNA; multipartite (an L and S strand); linear and circular; negative, with ambisense capability; replication in cytoplasm, requires intact nucleus for reasons that remain unclear
Very powerful zoonosis. 20% mortality rate in humans.
- Likes to attack various cell types, especially macrophages ad fibroblasts. Replicates in the cytoplasm and matures by budding from plasma membrane. Steals glycoproteins and ribosomes from host cell.
- Causes hemorrhagic fever and kills one in five people it encounters.
- 1-2 week incubation period, but sudden onset of disseminated intravascular coagulation causes rapid death.
- Rodent control of calomys callosus. Isolation and barrier nursing prevents nosocomial spread.
- Must maintain electrolyte fluid and osmotic balance to manage hypotension and shock near end-stage of disease. Prophylaxis with Ribavirin orally or IV.
Role a die. If opponent gets a "five" s/he dies. If not, they survive the disease, but skip a turn to recover from massive bleeding.
Usually hangs out quietly with forest dwelling rodents. If you provoke it, good luck fighting back!!