RESPIRATORY SYNCYTIAL VIRUS (SUBTYPE B)
Taxonomy Order Mononegavirales; Family Paramyxoviridae; Subfamily Pneumovirinae
Morphology: Pleiomorphic; Spherical; 150-300 nm in diameter; enveloped, helical nucleocapsid
Genome: ssRNA; monopartite; linear; negative sense; replication and assembly in cytoplasm;
Most important respiratory pathogen of childhood!!! Subtype B less common and less virulent than A. But can kill some infants.
- Mucous membranes of nose and throat. Especially trachea, bronchi, bronchioles, alveoli.
- Can be fatal in infants a few months old
- Causes extensive pneumonitis, bronchiolitis, with areas of atelectasis and emphysema
- 3-5 day incubation; progression over 1-7 days
- Vaccinia recombinant RSV vaccine can help reduce severity and expedite recovery, but does not prevent infection
- New purified Fusion Protein Vaccines (PFPs) prepared from the F protein being tested
- Transmission via mucal shedding, fomites, and aerosol; Cover mouth, wash hands and infected fomites. Use disinfectants
- Passive immunization with intravenously administered RSV immune globulin (RespiGam) to reduce lower respiratory tract infection
Flip a coin. If you get "heads" opponent gets severe symptoms and dies. If "tails", then s/he only gets mild symptoms and recovers (opponent loses turn).
This mysterious foe will rob cribs unexpectedly.